Deaths with COVID-19 and from all-causes following first-ever SARS-CoV-2 infection in individuals with preexisting mental disorders: A national cohort study from Czechia

PLoS Medicine, Journal Year: 2024, Volume and Issue: 21(7), P. e1004422 - e1004422

Published: July 15, 2024

Background Evidence suggests reduced survival rates following Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection in people with preexisting mental disorders, especially psychotic before the broad introduction of vaccines. It remains unknown whether this elevated mortality risk persisted at later phases pandemic and when accounting for confounding effect vaccination uptake clinically recorded physical comorbidities. Methods findings We used data from Czech national health registers to identify first-ever serologically confirmed SARS-CoV-2 infections 5 epochs related different pandemic: 1st March 2020 30th September 2020, October 26th December 27th 31st 2021, April 2021 November 29th February 2022. In these people, we ascertained cases disorders using approaches: (1) per International Classification Diseases 10th Revision (ICD-10) diagnostic codes substance use, psychotic, affective, anxiety disorders; (2) ICD-10 above coupled a prescription anxiolytics/hypnotics/sedatives, antidepressants, antipsychotics, or stimulants Anatomical Therapeutic Chemical (ATC) classification codes. matched individuals counterparts who had no on age, sex, month year infection, status, Charlson Comorbidity Index (CCI). assessed deaths Disease 2019 (COVID-19) all-causes time period 28 60 days stratified Cox proportional hazards models, adjusting matching variables additional confounders. The number matched-cohorts ranged 1,328 epoch 1 854,079 5. proportion females 34.98% diagnosed use 3 71.16% treated mean age 40.97 years (standard deviation [SD] = 15.69 years) 56.04 (SD 18.37 2. People consistently dying COVID-19 2, 3, 4, 5, adjusted hazard ratios (aHRs) ranging 1.46 [95% confidence intervals (CIs), 1.18, 1.79] 1.93 CIs, 1.12, 3.32]. This patient group demonstrated also all-cause (aHR 1.43 1.23, 1.66] 1.99 1.25, 3.16]). models could not be reliably fit 1. an increased postinfection 1.30 1.14, 1.47] 1.59 1.19, 2.12]) 1.22 1.08, 1.38] 1.52 1.16, 1.98]). Cases based diagnosis treatment 1.03, 1.43] 1.91 2.91]). contrast these, decreased death 0.78 0.69, 0.88] 0.89 0.81, 0.98]) 0.83 0.77, 0.90] 0.88 0.83, 0.93]). affective both 0.87 0.79, 0.96] 0.90 0.99]), but broadly null effects other epochs. Given unavailability potentially influential confounders, particularly body mass index, tobacco smoking socioeconomic part detected associations might due residual confounding. Conclusions and, less robustly, persistently throughout pandemic. While it cannot ruled out that is confounding, excess fully explained by lower more comorbidities groups.

Language: Английский

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The Metabolic Vulnerability Index as A Novel Tool for Mortality Risk Stratification in a Large-scale Population-based Cohort

Redox Biology, Journal Year: 2025, Volume and Issue: 81, P. 103585 - 103585

Published: March 6, 2025

Metabolic malnutrition and inflammation-key mechanism links to redox imbalance-are fundamental pathologies that accelerate aging disease progression, ultimately leading death. The recently proposed metabolic vulnerability index (MVX) integrates multiple circulatory biomarkers closely linked both inflammatory factors. This study aims assess MVX's potential predict mortality in community-based population. In this large prospective study, we included UK Biobank participants who underwent plasma metabolomics analysis. Gender-specific MVX scores were calculated based on six established of mortality. Linear non-linear associations between assessed using Cox proportional hazards models restricted cubic spline models, respectively. Among the 274,092 UKB participants, 24,241 all-cause deaths occurred during a median follow-up period 13.7 years. A significant, graded positive association was observed quartiles risk (P for trend <0.05), with highest quartile exhibiting greatest (HR = 1.21 95 % CI 1.16-1.25 after full adjustment). Females had higher score than males < 0.05), but same faced greater risk. Baseline age comorbidities interacted interaction <0.05 synergy >1) Longitudinal analyses showed females persistently high significantly increased 1.39 fully adjusted model). Collectively, these findings highlight as novel tool captures vulnerabilities community residents, serves valuable resource identifying high-risk individuals Further research is warranted investigate underlying mechanisms establish causal relationships.

Language: Английский

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Association between long-term benzene exposure and inflammatory bowel disease in a national cohort: The modifying effect of genetic susceptibility

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 296, P. 118198 - 118198

Published: April 15, 2025

Language: Английский

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Association between body roundness index and incidence of type 2 diabetes in a population-based cohort study

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 16, 2025

Language: Английский

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Vitamin D status, vitamin D receptor polymorphisms, and risk of cardiometabolic multimorbidity

Nutrition Journal, Journal Year: 2025, Volume and Issue: 24(1)

Published: May 11, 2025

The prevalence of cardiometabolic multimorbidity (CMM) has increased substantially in recent years. Previous studies have established the associations between vitamin D, D receptor (VDR) polymorphisms, and risk individual disease (CMD). However, role these factors progression CMD to CMM or mortality remains unclear. This study aimed investigate VDR dynamic CMM, as well explore potential modification effect polymorphisms. Data for this cohort were extracted from UK Biobank. was defined coexistence at least two CMDs, including type 2 diabetes (T2D), coronary heart (CHD), stroke. A multi-state model used analyze serum 25(OH)D, polymorphisms CMM. sample included 396,192 participants. Over a median follow-up 13.8 years, 55,772 individuals experienced one 28,624 died. Compared participants with 25(OH)D < 25 nmol/L, those ≥ 75 nmol/L had HRs 0.70 (95% CI, 0.67, 0.72) baseline first (FCMD), 0.74 0.82) FCMD 0.66 0.62, 0.70) death, 0.84 0.77, 0.92) 0.85 0.70, 1.03) death. L-shaped relationships noted, threshold around 45 nmol/L. rs1544410 (BsmI) T alleles may detrimental effect, while rs11568820 (Cdx2) exert protective early stages progression. Additionally, significantly modified association certain Maintaining adequate levels, readily implementable intervention strategy, not only reduces initial but also delays Risk stratification based on provides further insights developing personalized prevention strategies.

Language: Английский

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Exploring the effects of COVID-19 on verbal memory function in schizophrenia: Multiple case study and brief literature review

Applied Neuropsychology Adult, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 12

Published: Oct. 14, 2024

Individuals recovering from COVID-19 may experience persistent impairment in verbal memory performance, potentially due to illness-related hippocampal injury. Although dysfunction is central schizophrenia, the interactions between this vulnerability and remain unclear, with no imaging studies addressing issue to-date. To explore gap generate hypotheses for future research, we adopted a multiple case study approach. Two pairs of individuals an ICD-10 diagnosis schizophrenia were selected, each consisting one positive anamnesis without. We calculated Reliable Change Index estimate clinical significance performance changes, annualized change rates volumes assessed against normative data. Compared their matches, cases did not show mutually consistent changes performance: experienced significant decline learning, while other showed general normalization test scores. Left comparatively slowed increase, right hippocampi decreased volume, although these atrophy exceed those expected population samples. Based on findings, hypothesize that alone does lead schizophrenia. Instead, relationship diseases depend additional factors. Our differed body mass index, systolic blood pressure, sex, phase illness, whole grey matter volume trajectories, leading us variables represent predictors or moderators relationship.

Language: Английский

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