Diagnosis of Bovine Respiratory Disease in feedlot cattle using blood 1H NMR metabolomics

Scientific Reports, Journal Year: 2020, Volume and Issue: 10(1)

Published: Jan. 10, 2020

Abstract Current diagnosis methods for Bovine Respiratory Disease (BRD) in feedlots have a low diagnostic accuracy. The current study aimed to search blood biomarkers of BRD using 1 H NMR metabolomics and determine their accuracy diagnosing BRD. Animals with visual signs (n = 149) visually healthy (non-BRD; n 148) were sampled analysis. Lung lesions indicative scored at slaughter. Non-targeted was used develop predictive algorithms disease classification regression trees. In the absence gold standard diagnosis, six reference define an animal as or non-BRD. Sensitivity (Se) specificity (Sp) estimate (Acc). Blood demonstrated high when (Acc 0.85), however less accurate rectal temperature 0.65), lung auscultation score 0.61) slaughter 0.71). Phenylalanine, lactate, hydroxybutyrate, tyrosine, citrate leucine identified metabolites importance classifying animals metabolome classified non-BRD shows potential use tool.

Language: Английский

---

African Swine Fever Virus Regulates Host Energy and Amino Acid Metabolism To Promote Viral Replication

Journal of Virology, Journal Year: 2021, Volume and Issue: 96(4)

Published: Dec. 15, 2021

In order to promote viral replication, viruses often cause severe immunosuppression and seize organelles synthesize a large number of metabolites required for self-replication. African swine fever virus (ASFV) has developed many strategies evade host innate immune responses.

Language: Английский

---

The evolving landscape of untargeted metabolomics

Nutrition Metabolism and Cardiovascular Diseases, Journal Year: 2021, Volume and Issue: 31(6), P. 1645 - 1652

Published: Jan. 23, 2021

Language: Английский

---

Milk biomarkers in relation to inherent and external factors based on metabolomics

Trends in Food Science & Technology, Journal Year: 2021, Volume and Issue: 109, P. 51 - 64

Published: Jan. 14, 2021

Language: Английский

---

Effects of polystyrene microplastics acute exposure in the liver of swordtail fish (Xiphophorus helleri) revealed by LC-MS metabolomics

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 850, P. 157772 - 157772

Published: Aug. 5, 2022

Language: Английский

---