Risk Factors for COVID-19 Infection Among Healthcare Workers. A First Report From a Living Systematic Review and meta-Analysis

Safety and Health at Work, Journal Year: 2022, Volume and Issue: 13(3), P. 263 - 268

Published: April 12, 2022

Health care workers (HCWs) are more than ten times likely to be infected with coronavirus infectious disease 2019 (COVID-19) the general population, thus demonstrating burden of COVID-19 among HCWs. Factors that expose HCWs a differentially high-risk acquisition important elucidate, enable appropriate public health interventions mitigate against high risk and reduce adverse outcomes from infection. We conducted systematic review meta-analysis summarize critically analyze existing evidence on SARS-CoV-2 factors With no geographical limitation, we included studies, in any country, reported (i) PCR laboratory diagnosis as an independent variable (ii) one or estimates (relative risk, odds ratio, hazard ratio) (iii) original, quantitative study design, published English Mandarian. Our initial search resulted 470 articles overall, however, only 10 studies met inclusion criteria for this review. Out review, inadequate/lack protective personal equipment, performing tracheal intubation, gender were most common COVID-19. Based random effects adjusted pooled relative who use equipment 29% (95% CI: 16% 41%) less test positive The also revealed performed intubations 34% 14% 57%) Interestingly, showed female at 11% higher (RR 1.11 95% CI 1.01–1.21) their male counterparts. This article presents findings living meta-analysis, therefore, did not yield many studies; it significant insight into better understanding HCWs; insights devising preventive strategies protect them CRD42020193508 available comments via link below https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020193508).

Language: Английский

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Diagnostic evaluation and cardiopulmonary exercise test findings in young athletes with persistent symptoms following COVID-19

British Journal of Sports Medicine, Journal Year: 2022, Volume and Issue: 56(16), P. 927 - 932

Published: May 18, 2022

Objectives Persistent or late-onset cardiopulmonary symptoms following COVID-19 may occur in athletes despite a benign initial course. We examined the yield of cardiac evaluation, including exercise testing (CPET), with after COVID-19, compared CPETs these and those without evaluated longitudinal changes CPET improvement symptoms. Methods This prospective cohort study young (18–35 years old) referred for that were present>28 days from diagnosis. findings post-COVID matched reference group healthy COVID-19. Post-COVID underwent repeat between 3 6 months evaluation. Results Twenty-one consecutive (21.9±3.9 old, 43% female) 3.0±2.1 No athlete had active inflammatory heart disease. reproduced presenting 86%. Compared (n=42), there was similar peak VO 2 but higher prevalence abnormal spirometry (42%) low breathing reserve (42%). Thirteen (62%) completed follow-up (4.8±1.9 months). The majority (69%) reduction symptoms, accompanied by oxygen pulse, resting rate (all p<0.05). Conclusion Despite high burden no clinically useful to reproduce either normal identification as potential therapeutic target. Improvement improvements parameters.

Language: Английский

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The association of COVID-19 severity and susceptibility and genetic risk factors: A systematic review of the literature

Gene, Journal Year: 2022, Volume and Issue: 836, P. 146674 - 146674

Published: June 14, 2022

Language: Английский

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Inflammatory mediators profile in patients hospitalized with COVID-19: A comparative study

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: July 25, 2022

Abnormal inflammatory mediator concentrations during SARS-CoV-2 infection may represent disease severity. We aimed to assess plasma in patients with Addis Ababa, Ethiopia. In this study, 260 adults: 126 hospitalized confirmed COVID-19 sorted into severity groups: severe (n=68) and mild or moderate (n=58), 134 healthy controls were enrolled. quantified 39 mediators using multiplex ELISA. Spearman rank correlation Mann-Whitney U test used identify mechanistically coupled compare Compared controls, had significantly higher levels of interleukins 1α, 2, 6, 7, 8, 10 15, C-reactive protein (CRP), serum amyloid A (SAA), intercellular adhesion molecule 1 (ICAM-1), vascular cell (VCAM-1), IFN-γ-inducible protein-10 (IP-10, CXCL10), macrophage protein-1 alpha (MIP-1α, CCL3), eotaxin-3 (CCL26), interferon-gamma (IFN-γ), tumor necrosis factor-α (TNF-α), basic fibroblast growth factor (bFGF), placental (PlGF), fms-like tyrosine kinase (Flt-1). Patients IL-10 lower macrophage-derived chemokine (MDC, CCL22) compared the group ( P&lt;0.05 ). receiver operating characteristic curve, SAA, IL-6 CRP showed strong sensitivity specificity predicting prognosis COVID-19. Greater age a significant association Our findings reveal that CRP, VCAM-1, CXCL10, CCL22 are promising biomarkers for severity, suggesting could be as warning indicators aid treatment.

Language: Английский

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Whole blood DNA methylation analysis reveals respiratory environmental traits involved in COVID-19 severity following SARS-CoV-2 infection

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Aug. 6, 2022

Abstract SARS-CoV-2 infection can cause an inflammatory syndrome (COVID-19) leading, in many cases, to bilateral pneumonia, severe dyspnea, and ~5% of these, death. DNA methylation is known play important role the regulation immune processes behind COVID-19 progression, however it has not been studied depth. In this study, we aim evaluate implication progression by means a genome-wide analysis combined with genotyping. The results reveal existence epigenomic functional pathways associated mediated genetic loci. We find environmental trait-related signature that discriminates mild from cases regulates, among other cytokines, IL-6 expression via transcription factor CEBP. analyses suggest interaction between contribution, genetics, epigenetics might be playing triggering cytokine storm described most cases.

Language: Английский

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