Annals of Medicine and Surgery, Journal Year: 2022, Volume and Issue: 84
Published: Nov. 17, 2022
Nowadays, coronavirus disease is a leading cause of death. Therefore, the study aimed to assess time recovery and its predictors among Covid-19 positive patients.
Language: Английский
Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11
Published: Feb. 27, 2024
Background The COVID-19 mortality rate continues to be high in low-income countries like Ethiopia as the new variant’s transmission expands and countries’ limited capacity combat disease causes severe outcomes, including deaths. aim of this study is determine magnitude its determinants Ethiopia. Methods main electronic databases searched were PubMed, CINAHL, Google Scholar, African journals online. included studies’ qualities assessed independently using Newcastle-Ottawa scale. data was extracted Microsoft Excel spreadsheet format. pooled effect size odds ratios with 95% confidence intervals across studies determined random-effects model. I 2 used estimate percentage overall variation due heterogeneity. Egger’s test funnel plot find published bias. A subgroup analysis conducted. a single on estimation by sensitivity analysis. Results total 21 42,307 participants final prevalence 14.44% (95% CI: 10.35–19.08%), significant heterogeneity (I = 98.92%, p < 0.001). risk from higher for patients comorbidity (AHR 1.84, 1.13–2.54) cardiovascular 2, 1.09–2.99) than their counterparts without these conditions. Conclusion number died comorbidities, particularly those disease, should receive special attention reduce mortality. Systematic review registration https://www.crd.york.ac.uk/PROSPERO/ , identifier (ID) CRD42020165740.
Language: Английский
Citations
3
Environmental Challenges, Journal Year: 2021, Volume and Issue: 6, P. 100428 - 100428
Published: Dec. 15, 2021
Coronavirus outbreak was a public health emergency. The surge of new confirmed cases and deaths observed in developing countries due to the occurrence variants. However, factors associated with duration recovery among admitted patients remained uncertain. Therefore, we assessed time from Covid-19 hospitalized at treatment center South Central, Ethiopia. We employed retrospective cross-sectional study 422 Bokoji Hospital July 1, 2020, through October 30, 2021. Data were entered, coded, analyzed using SPSS 26 version. computed survival probability Kaplan Meier method determined Cox regression analysis. Finally, interpretation adjusted hazard ratio (AHR) 95% Confidence Interval (CI) P-values less than 0.05 declared as statistically significant. Our found that median infection 13 days, an IQR 9-17 days. In multivariate regression, ≥ 60 years old (AHR = 0.66; CI: 0.49, 0.895), chronic pulmonary disease 0.67; 0.455, 0.978), Male 0.77; 0.611, 0.979), being on Intranasal oxygen care 0.56; 0.427-0.717) significantly recovery. Thus, providers centers should give strict follow-up priority for elders, underlying diseases, under supportive during case management.
Language: Английский
Citations
18
Infection and Drug Resistance, Journal Year: 2022, Volume and Issue: Volume 15, P. 3491 - 3501
Published: July 1, 2022
Background: The ongoing novel coronavirus disease 2019 (COVID-19) is triggering significant morbidity and mortality due to its contagious nature absence of definitive management. In Ethiopia, despite a number primary studies have been conducted estimate the case fatality rate (CFR) COVID-19, no review study has attempted summarize findings better understand pandemics virulence disease. Objective: To CFR COVID-19 factors contributing in Ethiopia. Methods: PRISMA guideline was followed. PubMed, Science Direct, CINAHL, SCOPUS, Hinari, Google Scholar were systematically searched using pre-specified keywords. Observational ie, cohort, cross-sectional, case-control included. Newcastle-Ottawa scale adapted for observational used assess quality included studies. defined as proportion cases with outcome death within given period. Factors at p-value < 0.05 described narratively from eligible articles. Results: A total 13 this study. Consequently, confirmed Ethiopia ranges between 1– 20%. Additionally, comorbid conditions, older age group, male sex, substance use, clinical manifestations (abnormal oxygen saturation level, atypical lymphocyte count, fever, shortness breath), severity, history surgery/trauma increased likelihood death. Conclusion: This shows that range almost equivalent other countries, country's low testing capacity detection reference population. Comorbid diseases, cigarette smoking, alcohol drinking, Therefore, alarming global situation rapidly evolving large-scale pandemics, urgent interdisciplinary interventions should be implemented those vulnerable groups lessen risk mortality. Furthermore, estimated all treatment rehabilitation centers country, underestimation could linked lack preparedness mitigation. large set prospective are also compulsory Keywords: rate, coronavirus, mortality,
Language: Английский
Citations
12
SAGE Open Medicine, Journal Year: 2022, Volume and Issue: 10
Published: Jan. 1, 2022
The spread of severe acute respiratory syndrome coronavirus 2 in Ethiopia is below par understood and to date has been poorly characterized by a lower number confirmed cases deaths other regions the sub-Sahara African including Ethiopia. Timely effective predictors for inpatient mortality rate were crucial improving management hospitalized cases. This study aimed assessed COVID-19 adult patients two diagnosed treatment centers, North West Ethiopia.A facility-based retrospective cohort was conducted among admitted Northwest Ethiopia, from 1 October 2020 30 December 2020. Data records children extracted using standardized checklist. Epi-Data version 3.2 used data entry, Stata 14 analysis. Bi-variable multivariable Cox regression analyses identify mortality. Finally, variables with P < 0.05 significant predictor mortality.The mean (±standard deviation) age participant 48.6 (±18.8) years. median (±interquartile range) time death reported after 13 (±6) days. overall incidence determined as 1.8 (95% confidence interval: 1.72, 2.15) per100 person per days observation. Cases at baseline ⩾ 61 years (adjusted hazard ratio = 1.56; 95% 1.3, 2.4), being male gender 1.9; CI: 2.1, 8.6), admission comorbidity ratio: 4.4, 2.3, 8.4), decreased neutrophil count ⩽ 65 103/uL (P 0.03) independent mortality.In general, 72.4% occurred within weeks admission. risk factors identified this multivariate model included elderly (⩾60 years), male, comorbidity, ⩽65 associated
Language: Английский
Citations
11
Infection and Drug Resistance, Journal Year: 2022, Volume and Issue: Volume 15, P. 795 - 806
Published: March 1, 2022
Background: Since coronavirus disease 2019 emergence, millions were infected and many dying because of the virus. Clinical features time to recovery admitted clients vary across settings. Therefore showing clinical from COVID-19 in a different setting is necessary design appropriate treatment preventive measures. So, this study attempted investigate Dilla University Referral Hospital center, Ethiopia. Methods: A retrospective was conducted 220 patients confirmed by real polymerase chain reaction center September 2020 July 2021. Data collected patients’ record. entry done an Epi-Info version 7.2.1.0 analyzed Statistical Package for Social Sciences 25 software. Descriptive statistics used features, median computed using Kaplan–Meier. Results: Common cough 209 (95%), shortness breath 153 (69.5%), fever 133 (60.5%), headache 75 (34.1%), easy fatigue 68 (30.9%), joint pain 56 (25.5%), tachypnea 197 (89.5%), hypoxia 95 (43.2%), tachycardia 83 (37.7%). The overall cases 5 days. There significant difference between probability severe moderate cases, mild (p=0.00), who had normal body temperature hypothermic (p=0.05), breathing rate bradypnea (p= 0.014). Conclusion: frequently show cough, breath, fever, headache, pain. Median Having temperature, rate, status statistically association with time. close follow up required client disease. Keywords: COVID-19, recover Letter Editor has been published article. Response
Language: Английский
Citations
11
Global Health, Journal Year: 2023, Volume and Issue: 2023, P. 1 - 10
Published: Sept. 12, 2023
Background. Since the end of 2019, world has been facing a new coronavirus disease 19 (COVID-19), which is considered global pandemic. COVID-19 major public health burden due to uncontrolled morbidity and mortality community. The World Health Organization estimates recovery time as 2 weeks for patients with mild infection 3 6 those serious illnesses. its predictors are not well studied in Ethiopia yet. Therefore, aim this study was estimate from among admitted Tibebe Ghion Specialized Hospital care treatment center, North West Ethiopia. Methods. An institution-based retrospective follow-up conducted 452 March 2020 September 2021. Simple random sampling using table number generators used select units. Data entry analysis were performed EpiData 3.1 Stata version 14, respectively. Bivariable multivariable Cox proportional hazard analyses identify time. AHR at 5% level significance significant predictors. Results: Among patients, 437 (88%) recovered, median 9 days. Recovery significantly related age (AHR = 0.98; 95% CI 0.97, 0.99), oxygen saturation 0.42; 0.31, 0.56), shortness breath 0.65; 0.47, 0.85), severity (moderate 0.63; 0.85) severe 0.32; 0.22, 0.47)), comorbidities 0.67; 0.53, 0.84). Conclusions recommendations: overall Older age, low saturation, breath, severe), history comorbidities, high-level WBC delayed On other hand, corticosteroid use shortens patients. Thus, presented older moderate disease, increased need be closely monitoring followed up by healthcare providers. In addition, there should special attention during administration corticosteroid.
Language: Английский
Citations
6
Pneumonia, Journal Year: 2023, Volume and Issue: 15(1)
Published: Nov. 5, 2023
The Novel Coronavirus disease (COVID-19) pandemic has become a global threat. Determining the time to recovery from COVID-19 is intended assist healthcare professionals in providing better care, and planning logistics. So, study aimed identify factors that affect for patients treated at Assosa treatment center, Benishangul Gumuz Regional State, Western Ethiopia.A retrospective design was conducted on 334 randomly selected center February 2021 July 2021. median survival time, Kaplan-Meier estimate, Log-Rank test were used describe data compare between groups. Cox PH model analyze first of patients, where hazard ratio, p-value, 95% CI ratio testing significance. Schoenfeld Cox-Snell residuals checking assumption.The overall incidence rate 13.79 per 100 (95% CI: 10.04, 18.95) person-days observations. 16 days. At end follow-up, 77.2% had developed an event recovery, rest 22.8% censored. mean age 45.22 years. Severe (AHR = 0.7876, 0.7090, 0.8748), presence symptoms 0.2814, 0.1340, 0.5914), comorbidity 0.1627, 0.1396, 0.1897), ≥ 90 oxygen saturation 3.2370, 2.161, 4.848), being older 0.9840, 0.971, 0.9973) found have statistically significant association with COVID-19.The concludes severe male having comorbidity, age, as poor prognostic also prolonged time. Therefore, health providers centers should give strict follow-up priority another co-morbid illness by focusing respiratory difficulties underlying pre-existing medical conditions manage severity recover quickly.
Language: Английский
Citations
6
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2022, Volume and Issue: 1869(2), P. 166592 - 166592
Published: Nov. 1, 2022
SARS-CoV-2 remains an acute threat to human health, endangering hospital capacities worldwide. Previous studies have aimed at informing pathophysiologic understanding and identification of disease indicators for risk assessment, monitoring, therapeutic guidance. While findings start emerge in the general population, observations high-risk patients with complex pre-existing conditions are limited. We addressed gap existing knowledge regard a differentiated dynamics infection while specifically considering stage severity. biomedically characterized quantitative proteomics hospitalized cohort COVID-19 mild severe symptoms suffering from different (co)-morbidities comparison both healthy individuals non-COVID related inflammation. Deep clinical phenotyping enabled individual trajectories patients. By use individualized phase assignment, proteome analysis revealed severity dependent type-2-centered host response side-by-side specific antiviral immune reaction early disease. The phenomena such as neutrophil extracellular trap (NET) formation pro-coagulatory characterizing was successfully validated second cohort. Together regulation proteins SARS-CoV-2-specific identified by screening, we not only confirmed results previous but provide novel information biomarker therapy development.
Language: Английский
Citations
10
Pathogens, Journal Year: 2022, Volume and Issue: 11(5), P. 551 - 551
Published: May 7, 2022
There is an urgent need for oral drug the treatment of mild to moderate outpatient SARS-CoV-2. Our preclinical and clinical study’s aim was determine safety preliminary efficacy TQ Formula (TQF), in In a double-blind, placebo-controlled phase 2 trial, we randomly assigned (1:1 ratio) non-hospitalized, adult (>18 years), symptomatic SARS-CoV-2 patients receive TQF or placebo. The primary endpoints were median time-to-sustained-clinical-response (SCR). SCR 6 days arm vs. 8 placebo (p = 0.77), 5 7.5 high-risk cohort, HR 1.55 (95% CI: 0.70, 3.43, p 0.25). No significant difference found rate AEs 0.16). led significantly faster decline total symptom burden (TSB) < 0.001), increase cytotoxic CD8+ 0.042) helper CD4+ central memory T lymphocytes. exhibited vitro inhibitory effect on entry five variants. well-tolerated. While time-to-SCR did not reach statistical significance; it shorter preclinical/clinical signals activity across multiple significant. Therefore, confirmatory study planned.
Language: Английский
Citations
9
Infection and Drug Resistance, Journal Year: 2022, Volume and Issue: Volume 15, P. 3047 - 3062
Published: June 1, 2022
Background: The world is currently facing a pandemic of Coronavirus Disease 2019 (Covid-19). It has caused significant morbidity and mortality. So far little known about recovery time (prolonged hospital stay) from Covid-19 its determinants in Ethiopia as well the study area. Therefore, aim this was to determine Covid-19, identify predictors among patients admitted treatment centers Southern Nations Nationalities Peoples Region (SNNPR). Methods Materials: A facility-based retrospective cohort conducted care SNNPR May 30, 2020 October 15, 2021. sample 845 included study. Summarization data done using mean (standard deviation) median (inter quartile range). Kaplan–Meier Survival Curve used estimate independent effects covariates on analyzed multivariable Cox-proportional hazard model. Results: incidence density 8.24 per 100 person-days (95% CI: 7.67, 8.85). overall 10 days (IQR: 8– 16 days). Critical stage (aHR = 0.19, 95% 0.12, 0.29), severe 0.40, 0.29, 0.56), mechanical ventilation 0.20, 0.073, 0.56) center 0.68, 0.51, 0.90) were rate patients. Conclusion: relatively short. person-days. lower for at higher levels severity need ventilation. Early identification required admission. Special attention, critical follow–up management warranted severity. Keywords: COVID-19, recovery, density,
Language: Английский
Citations
9