Omicron Infections in Otolaryngology Practice: A Retrospective Observational Study on Testing, Symptoms and Vaccination Status

Advances in Infectious Diseases, Journal Year: 2023, Volume and Issue: 13(01), P. 81 - 95

Published: Jan. 1, 2023

Background: With the appearance of SARS-CoV-2 Omicron variant high rate vaccination breakthroughs showed that current vaccines against COVID-19 can no longer provide adequate protection infection. However, it is still assumed might have a positive effect on course disease. In Germany, general practitioners and specialists are usually first treatment providers for acute illnesses. addition, patients with infections upper respiratory tract often primarily consult an ear, nose throat specialist. Most Omicron-infected people mild disease and, if necessary, receive medical care outpatient basis. Little known about effectiveness corona vaccinations in relation to clinical symptoms. our office, we recorded sharp increase Omicron-infections beginning 2022, despite COVID-19. retrospective analysis, evaluated data tested regard symptoms reported status. The focus was particularly question what extent status case influences Methods: We retrospectively all quarter 2022 who were suspected At time, dominant Germany. Clinical symptoms, cycle threshold (Ct) values, recorded. Symptomatic negative served as control group. Results: Of total cohort (n = 353), 241 (68%) positive. corona-positive essentially similar those moderate cold, but compared SARS-CoV-2-negative 69) clear shift favor fever (35% versus 16%), cough (76% 52%) increased feeling illness (59% 43%), respectively. Ct values revealed difference between unvaccinated (mean 19.15; SD 3.52) vaccinated cases 18.15; 3.87; p 0.272). There significant correlation symptom score different age groups (age 12 17, r (28) 0.26, 0.26; > 18 60, (191) 0.06, 0.378). Conclusions: According results variant, there differences concerning or potential infectivity, especially children adolescents. This impact further programs.

Language: Английский

Transmission and the evolution of diseases caused by chlamydia trachomatis, SARS-CoV-2, and plasmodium species.

Published: Jan. 1, 2023

Principles of natural selection have proven valuable for explaining why pathogens cause the diseases that they do. In theory, evolved level host exploitation should reflect how dependent a pathogen is on health transmission. This dependency shaped by transmission mode and opportunity, which therefore be predictors disease manifestations. this dissertation, I apply these principles to investigations depression in Chlamydia trachomatis virulence SARS-COV-2 Plasmodium species. dissertation has five chapters. chapter I, describe theoretical foundation my research. also briefly introduce each study system. II, evaluate whether C. associated with based candidate mechanism within-host persistence. hypothesize independent urogenital symptoms, effect stronger females than males. III, assess evolutionary trends SARS-CoV-2’s viral loads conducting meta-analyses published results. From perspective respiratory correlate positively environmental survivability, trend reduced virulence. IV, qualitatively review epidemiological factors may affect malaria severity critically hypothesis evolves as function intensity. summarize main findings conclusions from chapters II through IV. discuss future research directions potential applications.

Language: Английский