Faecal microbiota transplantation associated adverse events DOI Creative Commons
Rafał Patryn, Natalia Kaźmierczak-Wojtaś, Lucyna Bułaś

et al.

Current Issues in Pharmacy and Medical Sciences, Journal Year: 2024, Volume and Issue: 37(3), P. 171 - 178

Published: Sept. 1, 2024

Abstract Faecal microbiota transplantation (FMT) aims to restore intestinal balance with the objective of normalising its composition and achieve therapeutic benefits. The procedure involves administration fresh or frozen faecal microbes from a healthy donor into recipient’s gastrointestinal tract intent proper structure functionality microbial community. Evidence showing positive effects FMT is abundant, however, less attention has been devoted FMT-associated adverse events, especially in relation liver diseases. Based on literature review, studies reports regarding events since beginning use, have analysed. review covering period 2010-2022 was undertaken accordance PRISMA guidelines. Studies conducted patient population suffering various types forms disease proven possible effectiveness method reported moderate (nausea, constipation, flatulence). Severe occurring were also noted. No safety issues infection signals associated observed performed within cirrhosis. present scientific reports, publications reviews describes literature. transplants are classified as mild, severe, among others, diarrhoea, fever, infections death. There need implement screening programme personalised methods. Further research recommended assess monitor efficacy, benefits risks.

Language: Английский

Fecal microbiota transplantation: current challenges and future landscapes DOI
Abbas Yadegar, Haggai Bar‐Yoseph, Tanya Monaghan

et al.

Clinical Microbiology Reviews, Journal Year: 2024, Volume and Issue: 37(2)

Published: May 8, 2024

SUMMARYGiven the importance of gut microbial homeostasis in maintaining health, there has been considerable interest developing innovative therapeutic strategies for restoring microbiota. One such approach, fecal microbiota transplantation (FMT), is main "whole microbiome replacement" strategy and integrated into clinical practice guidelines treating recurrent

Language: Английский

Citations

45
The Importance of Microbiota and Fecal Microbiota Transplantation in Pancreatic Disorders DOI Creative Commons
Adrian Boicean, Cristian Ichim, Samuel Bogdan Todor

et al.

Diagnostics, Journal Year: 2024, Volume and Issue: 14(9), P. 861 - 861

Published: April 23, 2024

The role of the intestinal microbiota in diagnosis and treatment pancreatic diseases is increasingly significant. Consequently, fecal transplantation (FMT) emerging as a promising therapeutic avenue for various disorders, including cancer, pancreatitis, type 1 diabetes (T1D). This innovative procedure entails transferring gut from healthy donors to individuals affected by ailments with potential restore balance alleviate associated symptoms. FMT represents pioneering approach improve patient outcomes diseases, offering tailored treatments customized individual microbiomes specific conditions. Recent research highlights benefits targeting personalized interventions disorders. However, comprehensive understanding intricate interplay between physiology warrants further investigation. necessity additional studies endeavors remains crucial, especially elucidating both adult pediatric cases pathological

Language: Английский

Citations

26
Microbiota therapeutics for inflammatory bowel disease: the way forward DOI Creative Commons
Lukas Bethlehem, María Manuela Estevinho, Ari Grinspan

et al.

˜The œLancet. Gastroenterology & hepatology, Journal Year: 2024, Volume and Issue: 9(5), P. 476 - 486

Published: April 8, 2024

Language: Английский

Citations

22
Modulating the microbiome in chronic liver diseases- current evidence on the role of fecal microbiota transplantation DOI Creative Commons
Srishti Saha,

Bernd Schnabl

Expert Review of Gastroenterology & Hepatology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

The gut microbiota has a complex relationship with the human host and is key to maintaining health. Disruption of healthy diverse microbial milieu plays an important role in pathogenesis several diseases including

Language: Английский

Citations

2
Phage-microbe dynamics after sterile faecal filtrate transplantation in individuals with metabolic syndrome: a double-blind, randomised, placebo-controlled clinical trial assessing efficacy and safety DOI Creative Commons
Koen Wortelboer, Patrick A. de Jonge, Torsten P. M. Scheithauer

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Sept. 12, 2023

Bacteriophages (phages) are bacterial viruses that have been shown to shape microbial communities. Previous studies faecal virome transplantation can decrease weight gain and normalize blood glucose tolerance in diet-induced obese mice. Therefore, we performed a double-blind, randomised, placebo-controlled pilot study which 24 individuals with metabolic syndrome were randomised filtrate (FFT) from lean healthy donor (n = 12) or placebo 12). The primary outcome, change metabolism, secondary outcomes, safety longitudinal changes within the intestinal bacteriome phageome, assessed baseline up 28 days. All included subjects completed analyses. While overall metabolism not significantly different between both groups, FFT is well-tolerated without any serious adverse events. phage virion composition altered two days after as compared placebo, coincides more virulent phage-microbe interactions. In conclusion, provide evidence gut phages be safely administered transiently alter microbiota of recipients.

Language: Английский

Citations

25
Fecal microbiota transplantation and next-generation therapies: A review on targeting dysbiosis in metabolic disorders and beyond DOI Creative Commons
Zenawork Sahle,

Getabalew Engidaye,

Demissew Shenkute

et al.

SAGE Open Medicine, Journal Year: 2024, Volume and Issue: 12

Published: Jan. 1, 2024

The human microbiome, particularly the gut has emerged as a central determinant of health and disease. Dysbiosis, an imbalance in microbial composition gut, is associated with variety metabolic other diseases, highlighting potential for microbiota-targeted treatments. Fecal microbiota transplantation received considerable attention promising therapy to modulate microbiome restore homeostasis. However, challenges remain, including standardization, safety, long-term efficacy. This review summarizes current knowledge on fecal describes next generation therapies targeting microbiome. looked at mechanistic understanding alternative strategies, elucidating their role improving dysbiosis-associated disorders, such obesity, type 2 diabetes others. Additionally, this discussed growing application Insights from clinical trials, preclinical studies, emerging technologies provide comprehensive overview evolving landscape microbiome-based interventions. Through critical assessment advances prospects, aims highlight therapeutic pave way innovative approaches precision medicine personalized

Language: Английский

Citations

15
The Gut Microbiota and Diabetes: Research, Translation, and Clinical Applications—2023 Diabetes, Diabetes Care, and Diabetologia Expert Forum DOI Creative Commons
Mariana X. Byndloss, Suzanne Devkota, Frank A. Duca

et al.

Diabetes Care, Journal Year: 2024, Volume and Issue: unknown

Published: June 24, 2024

This article summarizes the state of science on role gut microbiota (GM) in diabetes from a recent international expert forum organized by Diabetes, Diabetes Care, and Diabetologia, which was held at European Association for Study 2023 Annual Meeting Hamburg, Germany. Forum participants included clinicians basic scientists who are leading investigators field intestinal microbiome metabolism. Their conclusions were as follows: 1) GM may be involved pathophysiology type 2 diabetes, microbially produced metabolites associate both positively negatively with disease, mechanistic links functions (e.g., genes butyrate production) glucose metabolism have recently emerged through use Mendelian randomization humans; 2) highly individualized nature poses major research obstacle, large cohorts deep-sequencing metagenomic approach required robust assessments associations causation; 3) because single-time point sampling misses intraindividual dynamics, future studies repeated measures within individuals needed; 4) much will to determine applicability this expanding knowledge diagnosis treatment, novel technologies improved computational tools important achieve goal.

Language: Английский

Citations

7
Anaerobic Feces Processing for Fecal Microbiota Transplantation Improves Viability of Obligate Anaerobes DOI Creative Commons
Mèlanie V. Bénard, Iñaki Arretxe, Koen Wortelboer

et al.

Microorganisms, Journal Year: 2023, Volume and Issue: 11(9), P. 2238 - 2238

Published: Sept. 5, 2023

Fecal microbiota transplantation (FMT) is under investigation for several indications, including ulcerative colitis (UC). The clinical success of FMT depends partly on the engraftment viable bacteria. Because vast majority human gut consists anaerobes, currently used aerobic processing protocols donor stool may diminish bacterial viability transplanted material. This study assessed effect four techniques (i.e., anaerobic and aerobic, both direct after temporary cool storage) viability. By combining culturing customized media anaerobes with 16S rRNA sequencing, we could successfully culture identify bacteria present in raw fecal suspensions. We show that superior to conditions preserving obligate butyrate-producing related response patients, Faecalibacterium, Eubacterium hallii, Blautia. oxygen exposure during decreased when samples were stored long-term. Our results confirm importance sample conditioning preserve oxygen-sensitive Anaerobic lead increased FMT, which should further be investigated trials.

Language: Английский

Citations

14
Can fecal microbiota transplantations modulate autoimmune responses in type 1 diabetes? DOI
Coco M. Fuhri Snethlage,

Douwe de Wit,

Koen Wortelboer

et al.

Immunological Reviews, Journal Year: 2024, Volume and Issue: 325(1), P. 46 - 63

Published: May 16, 2024

Type 1 diabetes (T1D) is a chronic autoimmune disease targeting insulin-producing pancreatic beta cells. T1D multifactorial incorporating genetic and environmental factors. In recent years, the advances in high-throughput sequencing have allowed researchers to elucidate changes gut microbiota taxonomy functional capacity that accompany development. An increasing number of studies shown role mediating immune responses health disease, including autoimmunity. Fecal transplantations (FMT) been largely used murine models prove causal microbiome progression be safe effective treatment inflammatory human diseases. this review, we summarize discuss research regarding microbiota-host interactions T1D, current advancement therapies for usefulness FMT explore immunity encounters shape course type diabetes.

Language: Английский

Citations

5
The gut microbiota and diabetes: research, translation, and clinical applications – 2023 Diabetes, Diabetes Care, and Diabetologia Expert Forum DOI Creative Commons
Mariana X. Byndloss, Suzanne Devkota, Frank A. Duca

et al.

Diabetologia, Journal Year: 2024, Volume and Issue: 67(9), P. 1760 - 1782

Published: June 24, 2024

Abstract This article summarises the state of science on role gut microbiota (GM) in diabetes from a recent international expert forum organised by Diabetes , Care and Diabetologia which was held at European Association for Study 2023 Annual Meeting Hamburg, Germany. Forum participants included clinicians basic scientists who are leading investigators field intestinal microbiome metabolism. Their conclusions were as follows: (1) GM may be involved pathophysiology type 2 diabetes, microbially produced metabolites associate both positively negatively with disease, mechanistic links functions (e.g. genes butyrate production) glucose metabolism have recently emerged through use Mendelian randomisation humans; (2) highly individualised nature poses major research obstacle, large cohorts deep-sequencing metagenomic approach required robust assessments associations causation; (3) because single time point sampling misses intraindividual dynamics, future studies repeated measures within individuals needed; (4) much will to determine applicability this expanding knowledge diagnosis treatment, novel technologies improved computational tools important achieve goal.

Language: Английский

Citations

5