Neural complexity is increased after low doses of LSD, but not moderate to high doses of oral THC or methamphetamine

Neuropsychopharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 29, 2024

Language: Английский

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Examining population structure across multiple collections of Cannabis

Genetic Resources and Crop Evolution, Journal Year: 2024, Volume and Issue: 71(8), P. 4705 - 4722

Published: March 16, 2024

Language: Английский

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Molecular Mechanisms Underlying Potential Pathogen Resistance in Cannabis sativa

Plants, Journal Year: 2023, Volume and Issue: 12(15), P. 2764 - 2764

Published: July 25, 2023

Cannabis (Cannabis sativa L.) is one of the earliest cultivated crops, valued for producing a broad spectrum compounds used in medicinal products and being source food fibre. Despite availability its genome sequences, few studies explore molecular mechanisms involved pathogen defense, underlying biological pathways are poorly defined places. Here, we provide an overview defence responses against common pathogens, such as Golovinomyces spp., Fusarium Botrytis cinerea Pythium spp. For each these after summary their characteristics symptoms, identifying genes resistance mechanisms. Many focus on potential involvement disease-resistance genes, while others refer to other plants however whose results may be use research. Omics investigations allowing identification candidate highlighted, editing approaches generate resistant species based CRISPR/Cas9 technology discussed. According emerging results, model including both immune plant–pathogen interactions finally proposed. To our knowledge, this first review Cannabis.

Language: Английский

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Progress in the analysis of phytocannabinoids by HPLC and UPLC (or UHPLC) during 2020–2023

Phytochemical Analysis, Journal Year: 2024, Volume and Issue: 35(5), P. 927 - 989

Published: June 4, 2024

Organic molecules that bind to cannabinoid receptors are known as cannabinoids. These possess pharmacological properties similar those produced by Cannabis sativa L. High-performance liquid chromatography (HPLC) and ultra-performance (UPLC, also ultra-high-performance chromatography, UHPLC) have become the most widely used analytical tools for detection quantification of phytocannabinoids in various matrices. HPLC UPLC (or usually coupled an ultraviolet (UV), photodiode array (PDA), or mass spectrometric (MS) detector.

Language: Английский

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Peer-review Blinded Assay Test (P-BAT): a framework for trustless laboratory quality assurance for state-regulated cannabis markets

Journal of Cannabis Research, Journal Year: 2025, Volume and Issue: 7(1)

Published: Jan. 21, 2025

Abstract The purpose of laboratory testing in the cannabis industry is to ensure public safety by preventing products that exceed hazardous limits contaminants from reaching consumers, and provide consumers with transparent accurate label information so they can make informed decisions when purchasing using products. However, does not exist a vacuum incentives—some incentives are direct conflict what best for consumers. For example, cultivators distributors will prefer use services laboratories find highest THC concentrations or lowest contaminant concentrations, regardless accuracy their results. Laboratories will, therefore, be incentivized serve over end consumer. present essay proposes framework quality assurance combats these perverse incentives. following proposed called Peer-review Blinded Assay Test (P-BAT), validation process where each tests competing labs own lab, but blinded fashion values said produced labels, unknown. This system self-review peer-review designed cost-efficient, transparent, nearly self-funded, implemented any state two more laboratories, most importantly, it trustless—there no need trust behavior one actor as “gold standard”. While primary objective this focus on performance, also highlight other common problems such product adulteration poor storge practices. Data P-BAT should publicly available about purchases based data derived P-BAT. Doing would further incentivize accountable consumer instead distributors.

Language: Английский

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Cannabis use to manage opioid cravings among people who use unregulated opioids during a drug toxicity crisis

International Journal of Drug Policy, Journal Year: 2023, Volume and Issue: 119, P. 104113 - 104113

Published: July 21, 2023

Language: Английский

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High-Potency Cannabis Use and Health: A Systematic Review of Observational and Experimental Studies

American Journal of Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Amid continuously rising concentrations of delta-9-tetrahydrocannabinol (THC) in cannabis (i.e., potency), high-potency is a major topic contemporary policy discussions, yet its impact on health not well understood. The authors conducted systematic review observational and experimental studies examining the relationship between use range outcomes. Records were obtained from search five biomedical research databases. developed ecologically relevant potency (percent THC) exposure-comparison categories (1%-9%, 10%-19%, 20%-30%, kief/resin [∼30%-50%], concentrates [≥60%]) used landmark scientific report cannabinoids to determine outcome eligibility. Two reviewers independently article screening selection, extraction, quality assessment. Findings synthesized using both quantitative (association direction, binomial test) narrative approaches. Certainty evidence was determined via Grading Recommendations, Assessment, Development, Evaluations (GRADE) framework. Of 4,545 screened records, 42 eligible. Most addressed outcomes mental health, "problem" use, other substance domains. domain suggestive an association with higher-potency use. less consistent domains but tended favor poorer Therapeutic limited mixed. Overall, certainty "very low." within Research largely cross-sectional spanning few adverse domains, underscoring need for prospective probing therapeutic, cardiorespiratory, cancer, pre- perinatal Policies curb may be warranted while base improves.

Language: Английский

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Human Milk Cannabinoid Concentrations and Associations with Maternal Factors: The Lactation and Cannabis (LAC) Study

Breastfeeding Medicine, Journal Year: 2024, Volume and Issue: 19(7), P. 515 - 524

Published: May 2, 2024

As cannabis use increases among reproductive-aged women, there is a growing need to better understand the presence of cannabinoids in milk produced by women using cannabis. It unclear how concentrations such as delta-9-tetrahydrocannabinol (Δ

Language: Английский

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Label Accuracy of Legal Oral Cannabis Oil Products in Ontario, Canada

JAMA Network Open, Journal Year: 2024, Volume and Issue: 7(6), P. e2414922 - e2414922

Published: June 5, 2024

This case series compares amounts of tetrahydrocannabinol and cannabidiol reported on product labels vs levels found in laboratory testing legal oral cannabis oil products Ontario, Canada.

Language: Английский

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Regulatory Framework for Cannabis: A Position Paper From the American College of Physicians

Annals of Internal Medicine, Journal Year: 2024, Volume and Issue: 177(8), P. 1104 - 1105

Published: July 22, 2024

Cannabis, also known as marijuana, is the dried flowers, stems, seeds, and leaves of

Language: Английский

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