Mesenchymal stem/stromal cells- a principal element for tumour microenvironment heterogeneity DOI Creative Commons
Li Sun,

Yongliang Yao

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 9, 2023

The heterogeneity of the tumor microenvironment (TME) is a major obstacle in cancer treatment, making most therapeutic interventions palliative rather than curative. Previous studies have suggested that reason for low efficacy immunotherapy and relapse original responders over time may be due to complex network mesenchymal stem/stromal cells (MSCs), population multipotent progenitor existing variety tissues. Cancer-associated MSCs (CA-MSCs) already been isolated from various types tumors are characterized by their vigorous pro-tumorigenic functions. Although roles CA-MSCs different sources vary widely, origins still poorly understood. Current evidence suggests when local resident or distally recruited interact with other components TME, "naïve" undergo genetic functional changes form CA-MSCs. In this review, we mainly focus on multiple derived sources, which help elucidating formation function entire as well discover innovative targets anti-cancer therapies.

Language: Английский

Stromal-Modulated Epithelial-to-Mesenchymal Transition in Cancer Cells DOI Creative Commons
Huda I. Atiya,

Grace Gorecki,

Geyon L. Garcia

et al.

Biomolecules, Journal Year: 2023, Volume and Issue: 13(11), P. 1604 - 1604

Published: Nov. 1, 2023

The ability of cancer cells to detach from the primary site and metastasize is main cause cancer- related death among all types. Epithelial-to-mesenchymal transition (EMT) first event metastatic cascade, resulting in loss cell–cell adhesion acquisition motile stem-like phenotypes. A critical modulator EMT stromal tumor microenvironment (TME), which can promote a mesenchymal phenotype through direct interaction with or changes broader microenvironment. In this review, we will explore role modulating cell EMT, particular emphasis on function stromal/stem (MSCs) activation EMT-inducing pathways, extra cellular matrix (ECM) remodeling, immune alteration, metabolic rewiring.

Language: Английский

Citations

13
Patient-Derived Organoids Recapitulate Pathological Intrinsic and Phenotypic Features of Fibrous Dysplasia DOI Creative Commons
Ha-Young Kim,

Clémentine Charton,

Jung Hee Shim

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(9), P. 729 - 729

Published: April 23, 2024

Fibrous dysplasia (FD) is a rare bone disorder characterized by the replacement of normal with benign fibro-osseous tissue. Developments in our understanding pathophysiology and treatment options are impeded lack suitable research models. In this study, we developed an vitro organotypic model capable recapitulating key intrinsic phenotypic properties FD. Initially, transcriptomic profiling individual cells isolated from patient lesional tissues unveiled intralesional molecular cellular heterogeneity. Leveraging these insights, established patient-derived organoids (PDOs) using primary obtained FD lesions. Evaluation PDOs demonstrated preservation fibrosis-associated constituent cell types transcriptional signatures observed Additionally, retained distinct constellations genomic metabolic alterations characteristic Histological evaluation further corroborated fidelity important features that underscore their pathophysiological relevance. Our findings represent meaningful progress field, as they open up possibility for modeling lesions three-dimensional context may signify first step towards creating personalized platform therapeutic studies.

Language: Английский

Citations

5
Reflections and perspectives on epigenetically mediated biological control: compromises in cancer and skeletal pathology DOI Creative Commons
Gary S. Stein

Academia Biology, Journal Year: 2025, Volume and Issue: 3(2)

Published: April 11, 2025

Establishing DNA as the genetic material, deciphering code and defining double helical structure of genome provided a foundation for pursuing mechanistic understanding gene expression that is operative biological control pathology. Equally important are series discoveries have established epigenetic mechanisms, defined by non-DNA-encoded regulation, mediated an evolving histone supports chromatin states, complementary obligatory determinants activity. Evidence accruing pivotal contributions parameters to required development differentiation well transient sustained responsiveness physiological regulatory cues support cell structure, function, survival, tissue repair remodeling. Epigenetic emerging decisive contributor compliance highly integrative processes balance phenotypic function tumor suppression with aberrant accompanies onset progression disease, strikingly illustrated tumorigenesis skeletal disorders.

Language: Английский

Citations

0
Mesenchymal stem/stromal cells- a principal element for tumour microenvironment heterogeneity DOI Creative Commons
Li Sun,

Yongliang Yao

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 9, 2023

The heterogeneity of the tumor microenvironment (TME) is a major obstacle in cancer treatment, making most therapeutic interventions palliative rather than curative. Previous studies have suggested that reason for low efficacy immunotherapy and relapse original responders over time may be due to complex network mesenchymal stem/stromal cells (MSCs), population multipotent progenitor existing variety tissues. Cancer-associated MSCs (CA-MSCs) already been isolated from various types tumors are characterized by their vigorous pro-tumorigenic functions. Although roles CA-MSCs different sources vary widely, origins still poorly understood. Current evidence suggests when local resident or distally recruited interact with other components TME, "naïve" undergo genetic functional changes form CA-MSCs. In this review, we mainly focus on multiple derived sources, which help elucidating formation function entire as well discover innovative targets anti-cancer therapies.

Language: Английский

Citations

7