Epidemiologic and genetic associations of female reproductive disorders with depression or dysthymia: a Mendelian randomization study

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: March 12, 2024

Abstract Observational studies have previously reported an association between depression and certain female reproductive disorders. However, the causal relationships different types of disorders remain unclear in terms direction magnitude. We conducted a comprehensive investigation using two-sample bi-directional Mendelian randomization analysis, incorporating publicly available GWAS summary statistics. Our aim was to establish relationship genetically predicted risk various pathological conditions, such as ovarian dysfunction, polycystic ovary syndrome(PCOS), cysts, abnormal uterine vaginal bleeding(AUB), endometriosis, leiomyoma uterus, infertility, spontaneous abortion, eclampsia, pregnancy hypertension, gestational diabetes, excessive vomiting pregnancy, cervical cancer, uterine/endometrial cancer. analyzed substantial sample size, ranging from 111,831 210,870 individuals, employed robust statistical methods, including inverse variance weighted, MR-Egger, weighted median, MR-PRESSO, estimate effects. Sensitivity analyses, Cochran's Q test, MR-Egger intercept leave-one-out funnel plots, were also ensure validity our results. Furthermore, factor analyses performed investigate potential mediators associated with these observed relationships. results demonstrated that genetic predisposition or dysthymia increased developing PCOS (OR = 1.43, 95% CI 1.28–1.59; P 6.66 × 10 –11 ), cysts 1.36, 1.20–1.55; 1.57 –6 AUB 1.41, 1.20–1.66; 3.01 –5 endometriosis 1.27–1.70; 2.21 –7 ) after Bonferroni correction, but no evidence for reverse causality. study did not find any supporting depression/dysthymia other In summary, provides specific findings emphasize importance management prevention treatment disorders, notably PCOS, AUB, endometriosis.

Language: Английский

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Quality of life, spiritual needs, and well-being of people affected by infertility and its treatment: quantitative results of a mixed-methods study

Journal of Assisted Reproduction and Genetics, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Infertility is a growing global health issue that significantly affects quality of life (QoL). Understanding its impact on QoL essential for developing effective healthcare interventions. This study explored QoL, well-being, and spiritual needs among individuals affected by infertility, with implications provision. Standardized questionnaire data from an anonymous mixed-methods was conducted October 2022 to January 2023 in Switzerland addressing (FertiQoL), (SpNQ-20), psychological well-being (WHO-5) undergoing fertility treatments. The analysis included 326 participants. FertiQoL scores were lowest the emotional domain (M = 46.35) highest relational 68.51), mean overall score 56.69, indicating moderate impacts. Participants without children reported lower WHO-5 than those (p < 0.05). indicated 13.89). SpNQ-20 results showed inner peace 1.82), followed generativity 1.09) existential 0.86), religious scoring 0.43). had higher highlights challenges revealing differences experiences between children. It emphasizes importance mental infertility care. Further research should focus impacts treatments, including depressive mood states.

Language: Английский

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Male support, depression, and anxiety in couples undergoing assisted reproductive technologies: a dyadic approach

Psychology Health & Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13

Published: April 14, 2025

Engagement in Assisted Reproductive Technologies (ART) represents a significant source of stress for infertile couples, particularly females/women undergoing these techniques, which may exacerbate their mental health and the quality marital relationship. The aim this study was to investigate relationships between male partner support matters related ART or pursuit pregnancy, concerns regarding impact infertility on relationship, symptoms anxiety depression couples ART. Path analyses were conducted using AMOS structural modeling software, applying an Actor-Partner Interdependence Mediation Model analysis. This approach estimates both effect individual's variable own outcome (actor effect) same from perspective (partner two variables: depression. Additionally, indirect effects variables included. final sample comprised 96 individuals (48 dyads) assisted human reproduction unit Spanish hospital. Hospital Anxiety Depression Scale (HADS), ad hoc items assessing perceived female partner, subscale Concern about relationship (Fertility Problem Inventory) used. results revealed presence actor, males/men, with self-reported predicting In females/women, only actor observed: lower level associated greater concern These findings highlight need interventions that address (self-reported partner-perceived) within psychological care programs

Language: Английский

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Prevalence and correlates of symptoms of depression, anxiety, and psychological distress among women of reproductive age with delayed conception in urban and peri-urban low to mid-socioeconomic neighborhoods of Delhi, India: A cross-sectional study

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(2), P. e0315347 - e0315347

Published: Feb. 5, 2025

Introduction One in six people of reproductive age experience infertility their lifetime. Infertility can have significant impacts on mental health. Psychological distress is a broad term encompassing emotional suffering and health discomfort that include symptoms anxiety depression but not limited to these conditions. We investigated the prevalence depression, anxiety, psychological associated risk factors among women with delayed conception. Methods A total 1530 were recruited from community settings Northern India. Quantitative data collected using 4-item Patient Health Questionnaire-4 (PHQ-4) which an ultra-brief self-report questionnaire consisting 2-item scale (PHQ-2) (generalized depression-2). Data between July 2020 August 2021. Descriptive analysis was conducted summarise characteristics distress. Logistic regression used identify for Results obtained responses all 1,530 scales. Over half (54.31%) participants had distress, whom 38.10% experiencing mild 10.59% moderate 5.62% severe Additionally,16.07% reported 20% depression. Factors were: (i) higher number children intended lifetime, (ii) longer duration trying get pregnant (> 18 months), (iii) continuous effort achieve pregnancy, (iv) women’s perception conception taking long, (v) social isolation, (vi) being emotionally or verbally abused by husband family members, (vii) having other co-morbidities such as hypertension, irregular menstrual cycles, bleeding regular abnormal vaginal discharge pain during sex. Conclusion This study demonstrates high burden faced low- mid-socioeconomic neighbourhoods North India including levels To better support individuals couples goals, we advocate integration psychosocial interventions improve outcomes promote well-being those facing delays achieving pregnancy. Specifically, addressing fostering supportive networks, combating violence towards women, incorporating fertility counselling group-based within healthcare are needed alleviate who difficulties conceiving. However, successful implementation recommendations may be challenged availability state’s resources, necessitating tailored strategies contextual adaptations.

Language: Английский

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Anxiety disorders in patients with infertility

Сибирский научный медицинский журнал, Journal Year: 2025, Volume and Issue: 45(1), P. 34 - 41

Published: Feb. 26, 2025

The article is devoted to anxiety disorders in patients with infertility. Along the physical aspects of this condition, many are experiencing significant emotional and psychological suffering. Women often experience feelings loss, guilt, loneliness. Unsuccessful trying get pregnant can be a source constant stress, affecting quality life relationships partners loved ones. literature review presents modern data on classification infertility, symptoms disorder, its etiology, role physiological, social factors, diagnosis disorder using clinical psychometric methods. methods treatment used described, including psychopharmacological psychotherapy. Anxiety frequent companion but they should fought. A comprehensive approach psychotherapy, medical support from ones helps women cope restore psycho-emotional balance.

Language: Английский

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Exploring 2SLGBTQIA+ Couples’ Experiences of Third-Party Reproduction

Archives of Sexual Behavior, Journal Year: 2025, Volume and Issue: unknown

Published: March 7, 2025

Language: Английский

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Chain mediation of rumination and anxiety state between mindfulness and depressed mood in infertile women

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 23, 2025

Language: Английский

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Dual mediating effects of marital satisfaction and family decision-making power on the relationship between self-disclosure and depressive symptoms in IVF-ET/ICSI-ET patients: a cross-sectional study

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 16

Published: April 24, 2025

Infertility has become one of the major public health problems, and assisted reproductive technology is main treatment. Depressive symptoms are most common mental illnesses treated with this technology. The aim study was to investigate effects partner self-disclosure, marital satisfaction family decision-making power on depressive in therapy patients. A cross-sectional survey satisfaction, performed 1076 patients who underwent IVF/ICSI-ET treatment at Reproductive Medicine Centre First Affiliated Hospital Anhui Medical University. (1) Age base were influencing factors symptoms. (2) results mediation effect test showed that had a significant suppressing patients, accounting for 30.05% total effect; partial mediating 28.81% effect. Marital play role between self-disclosure score helps reduce symptoms, but increase predicts In addition, highlight gender differences complexity relationships.

Language: Английский

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No Baby to Bring Home: Perinatal Loss, Infertility, and Mental Illness—Overview and Recommendations for Care

Current Psychiatry Reports, Journal Year: 2023, Volume and Issue: 25(11), P. 747 - 757

Published: Oct. 25, 2023

Language: Английский

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Analyzing the infertility burden of polycystic ovarian syndrome in China: A comprehensive age-period-cohort analysis with future burden prediction (1990–2030)

Gynecological Endocrinology, Journal Year: 2024, Volume and Issue: 40(1)

Published: July 11, 2024

Objective Polycystic ovarian syndrome (PCOS) is a common but complex endocrine disorder widely linked to infertility and miscarriage. This study assessed the correlation between PCOS infertility.

Language: Английский

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