Association between niacin intake and osteoarthritis in the US population based on NHANES 1999–2018

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 22, 2025

The relationship between niacin and osteoarthritis (OA) is not clear. Using a retrospective cohort study from the National Health Nutrition Examination Survey (NHANES), this aimed to investigate association intake osteoarthritis. This conducted cross-sectional analysis using data 1999–2018 was assessed univariate multivariate weighted logistic regression models restricted cubic spline curves (RCS). Nonlinear correlation analyzed by fitting smooth curve. In study, 30,620 participants were examined, with 1,864 individuals diagnosed osteoarthritis, resulting in prevalence of 5.74%. Utilizing regression, consistent inverse Niacin observed (OR = 0.99, 95% CI: 0.98–0.99, P 0.003). When treated as categorical variable, highest quartile (Q4) exhibited 33% reduced risk compared lowest (Q1) 0.67, 0.53–0.83, 0.0004). revealed non-linear (non-linear 0.022), 33.53 inflection point. Subgroup analyses further highlighted stronger Non − Hispanic Black other Race patients. results showed negative linear OA risk. By increasing niacin-rich foods, can be reduced, providing ideas for prevention treatment Further future studies are recommended validate our findings.

Language: Английский

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The association between dietary fiber intake and osteoarthritis: a cross-sectional study from the 1999–2018 U.S. National Health and Nutrition Examination Survey

Journal of Orthopaedic Surgery and Research, Journal Year: 2025, Volume and Issue: 20(1)

Published: Feb. 27, 2025

The relationship between dietary fiber intake and osteoarthritis (OA) remains unclear. This cross-sectional study, using data from the National Health Nutrition Examination Survey (NHANES), aimed to examine association OA. A analysis was conducted NHANES 1999 2018 assess Univariate multivariate weighted logistic regression models, along with restricted cubic spline (RCS) curves, were used evaluate relationship. total of 30,620 participants included in this whom 1,864 diagnosed OA, yielding a prevalence 5.74%. Multivariate revealed consistent inverse OA (OR = 0.99, 95% CI: 0.97–0.99, P 0.018). When treated as categorical variable, highest quartile (Q4) associated 27% lower risk compared lowest (Q1) 0.73, 0.58–0.92, 0.007). RCS indicated non-linear (non-linear 0.013). threshold effect interval suggested that range 14.4–26.7 g reduced while above level did not provide significant additional protection. findings demonstrate negative linear risk. Increasing consumption may reduce offering potential strategies for its prevention management. Further studies are needed confirm these findings.

Language: Английский

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White blood cell traits and lung cancer risk: a two-sample mendelian randomization analysis

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 4, 2025

This study aimed to investigate the potential association between white blood cell counts and risk of lung cancer, including its subtypes, through Mendelian randomization (MR) analysis. We conducted a two-sample MR analysis using genome-wide (GWAS) summary statistics for both exposure traits (eosinophil count, neutrophil lymphocyte monocyte basophil total count) outcome (lung cancer subtypes). The GWAS dataset included 29,266 cases (11273 adenocarcinoma (LUAD), 7426 squamous carcinoma (LSCC), 2664 small (SCLC)) 56,450 controls. In analysis, we employed methods such as Inverse variance weighted (IVW), median, MR-Egger regression, pleiotropy residual sum outlier. revealed an elevated (WBC) count significantly increased LUAD (IVW: OR = 1.484, 95% CI 1.219–1.749, p 0.003). results confirmed causal relationship 1.687, CI:1.542–1.830, < 0.001). An WBC was associated with higher LUAD. Additionally, subtypes indicated that plays crucial role in

Language: Английский

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Predictors of Satisfaction in Patients with Knee Osteoarthritis Treated with a Single Injection of Mannitol-Modified Crosslinked Hyaluronate Derivative

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(18), P. 5372 - 5372

Published: Sept. 11, 2024

There is a gap between the very positive opinion of patients and doctors regarding knee viscosupplementation (VS) contrasting results controlled studies. The objective this study was to evaluate overall satisfaction predictors with VS in osteoarthritis treated VS.

Language: Английский

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Osteoarthritis and social disadvantage interactions: retrospective overview and emergent findings and health implications

International Physical Medicine & Rehabilitation Journal, Journal Year: 2024, Volume and Issue: 9(1), P. 39 - 45

Published: March 22, 2024

Osteoarthritis, a widespread arthritic disease commonly resulting in considerable pain and functional disability is often found to vary among those deemed affected. While age, gender, genetics explain this, what does the research show specifically terms of extrinsic factors such as social disadvantage? This report aimed update known about context its role possible remediable osteoarthritis determinant if suboptimal. Using PUBMED data base others, studies published between January 1, 2000 March 20, 2024 concerning disadvantage linkages were sought carefully examined. As well, drawn from researcher’s repository reviewed. The search results revealed growing interest this topic where can be observed negatively influenced face one or more forms deprivation. Yet, very few clinical trials prevail either test validity idea apply these understandings preventing suffering. In light increasing burden, despite years research, it appears that maximize wellbeing for all, limit obviate unwanted associated health costs, resounding along with focus on advancing equity mitigating all deprivation strongly indicated.

Language: Английский

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Exploring the bidirectional relationship between localized musculoskeletal pain and gait abnormalities: a Mendelian randomization study

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 19, 2024

Background Abnormal gait will alter lower extremity joint mechanics load-bearing patterns, accelerate the osteoarticular disease process, trigger new oste-oarticular complications, and bring about multiple mobility impairments; scientific pain management strategies can help with walking training rehabilitation exercises. However, studies to date on relationship between localized musculoskeletal abnormalities have not reached definitive conclusions. Purpose To investigate bidirectional causal abnormalities. Methods The independent single nucleotide polymorphism (SNP) loci strongly associated were extracted as instrumental variables (IVs) from Genome-wide association study (GWAS) data of according preset thresholds, Inverse-variance weighted (IVW) method was used assess pain-related phenotypes abnormalities; Cochran Q test heterogeneity SNPs. Results Low back (OR=1.53, 95%CI=1.058~2.219, P=0.023) hip (OR=1.55, 95%CI=1.067~2.252, P=0.021) significantly genetically predisposed abnormalities, but knee (OR=2.15, 95%CI=0.234~19.789, P=0.498) susceptible None results reverse MR analysis supported causality. showed no among Conclusion This suggests a robust correlation, are related low pain. Our findings contribute deeper comprehension intricate interplay emphasizing importance employing tailored alleviate

Language: Английский

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