Association Between Stress‐Induced Weight Loss and Autophagy‐Related Gene Expression in the Hippocampus and Midbrain of Depression Model Mice DOI Creative Commons

Hiroaki Mori,

Yuta Yoshino,

Mitsutoshi Okano

et al.

Neuropsychopharmacology Reports, Journal Year: 2024, Volume and Issue: 45(1)

Published: Dec. 23, 2024

ABSTRACT Aim Recent studies have implicated autophagy in both weight regulation and depression. This study aimed to investigate the relationship between stress‐induced loss autophagy‐related gene expression a mouse model of Method Male C57BL/6 mice were subjected chronic immobilization stress (CIS) protocol for 14 days induce depressive‐like behavior. Body was measured before after CIS, behavior assessed using tail suspension test (TST). The levels genes ( Atg5 , Atg7 Atg12 Becn1 Mmp9 Fkbp5 Map1lc3b ) hippocampus midbrain evaluated reverse transcription‐quantitative PCR (RT‐qPCR). Serum cortisol also measured. Results CIS resulted significant increased immobility time TST, indicating not different CIS‐depression control mice. In hippocampus, significantly higher than midbrain, Increased expressions consistent with previous postmortem brains patients A negative correlation found mRNA change ratio CIS. Conclusion findings suggest that enhanced may be related pathology depression Fkbp5, an regulator, mediates loss.

Language: Английский

Additive impact of depression and social isolation on future cardiovascular disease and mortality: The mediated effect of cardiometabolic diseases DOI
Yao Ying-shui, Yongqiang Yang, Minqi Liao

et al.

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: 379, P. 342 - 349

Published: March 13, 2025

Language: Английский

Citations

0
Differences in all-cause mortality between urban and rural areas based on the intensity of long-term social isolation: findings from 17-year retrospective cohort study DOI
Jeong Min Yang, Jieun Hwang, Yoo-Kyung Boo

et al.

Annals of Epidemiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Association between self‐reported weight loss and new long‐term care insurance certifications: A 9‐year Japanese older adult cohort study DOI Open Access
Ryo Katayose, Mika Okura, Ayae Kinoshita

et al.

Geriatrics and gerontology international/Geriatrics & gerontology international, Journal Year: 2024, Volume and Issue: 24(12), P. 1320 - 1327

Published: Nov. 5, 2024

Aim This cohort study aimed to assess weight loss associated with new long‐term care insurance (LTCI) certifications over a 9‐year period, accounting for the competing risk of death. Methods We analyzed data from 3749 Japanese individuals aged ≥65 years in Kami Town, Hyogo Prefecture, Japan. Weight was assessed using Kihon Checklist during baseline survey. Data regarding LTCI were collected until March 2022. Cox proportional hazards models used calculate adjusted hazard ratios (HRs) certification because loss, confounding factors. To exclude effect risks, Fine‐Gray regression estimate subdistribution HRs. Subgroup analyses carried out after examination potential interactions between subjective cognitive function, body mass index categories and loss. Results The incidence rate 5.16 per 100 person‐years overall – broken down into 7.02 those 4.97 without. HR 1.35 (95% CI 1.15–1.59). Considering mortality as risk, 1.37 1.16–1.61). Conversely, no interaction observed function or categories. Conclusions Excluding mortality, identified factor certifications. However, Geriatr Gerontol Int 2024; 24: 1320–1327 .

Language: Английский

Citations

1
Malnutrition among Elderly Patients with Selected Chronic Diseases: Screening and Risk Factors at Minia University Hospital DOI Open Access

Fatma Yousef Mohammed,

Jehan Sayyed Ali,

Aml Sabra AbuBakr

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 015(2), P. 31 - 41

Published: June 3, 2024

Background: Malnutrition is a major geriatric syndrome with multiple causative factors and severe complications that lead to increased mortality morbidity rates specifically among older adults chronic diseases. Aim of the study: To assess malnutrition identify main risk associated elderly patients selected diseases (hypertension diabetes). Research design: A cross sectional descriptive research design was utilized. Subjects: purposive sample (100) involved in current study. Setting: The study carried out medical outpatient clinics, at Minia University Hospital, Egypt. Tools: Three tools were utilized collect data, First Tool: Patient Interview Structured Questionnaire, Second Nutritional Assessment (Mini Scale (MNAS) biochemical measurements. Third Risk Factors Questionnaire Results: It found more than half studied samples malnutrition, highly statistically significant differences regarding (age, income, education, physiological psychological factors).Conclusion: More diabetes and/or hypertension for malnutrition. Additionally, age, place residence, low income significantly affected their nutritional status. As well as, most noticeable them. Recommendations: Educational classes focusing on proper nutrition appropriate lifestyles disease (DM/hypertension or both) recommended, also having routine screening tests evaluate

Language: Английский

Citations

0
Capacidade intrínseca e resiliência física de pessoas idosas que vivem no domicílio DOI Creative Commons
Daiane de Souza Fernandes

Published: May 2, 2024

A análise fatorial mostrou que o modelo da Short Physical Performance Balance se ajustou aos dados.Participaram 168 participantes, maioria mulheres, média idade 77, 92 anos, baixa escolaridade e renda, viúvos, não moravam sozinhos, participação social, com apoio metade relatou difícil acesso serviços de saúde, baixo nível atividade física 18,65 KgF força pressão palmar.Os estressores maior impacto foram quedas (β= -0,21; p<0,001) polifarmácia -0,18; p=0,01).Os domínios capacidade intrínseca mais afetados a locomoção -0,46; p<0,001), vitalidade -0,13; p=0,05) audição -0,15; p=0,02).Na regressão final, as variáveis preditoras para resiliência foram: domínio -0,28; -0,27; semanal 0,21; preensão palmar 0,16; p=0,02) p=0,03).A mediação apresentam efeito direto sobre física, sendo observado um pela palmar.Conclusão: é influenciada pelos vitalidade, os saúde impacto.Sugere-se necessidade acompanhamento destas na rotina clínica implementações resolutivas no cuidado pessoa idosa.

Citations

0
Association Between Stress‐Induced Weight Loss and Autophagy‐Related Gene Expression in the Hippocampus and Midbrain of Depression Model Mice DOI Creative Commons

Hiroaki Mori,

Yuta Yoshino,

Mitsutoshi Okano

et al.

Neuropsychopharmacology Reports, Journal Year: 2024, Volume and Issue: 45(1)

Published: Dec. 23, 2024

ABSTRACT Aim Recent studies have implicated autophagy in both weight regulation and depression. This study aimed to investigate the relationship between stress‐induced loss autophagy‐related gene expression a mouse model of Method Male C57BL/6 mice were subjected chronic immobilization stress (CIS) protocol for 14 days induce depressive‐like behavior. Body was measured before after CIS, behavior assessed using tail suspension test (TST). The levels genes ( Atg5 , Atg7 Atg12 Becn1 Mmp9 Fkbp5 Map1lc3b ) hippocampus midbrain evaluated reverse transcription‐quantitative PCR (RT‐qPCR). Serum cortisol also measured. Results CIS resulted significant increased immobility time TST, indicating not different CIS‐depression control mice. In hippocampus, significantly higher than midbrain, Increased expressions consistent with previous postmortem brains patients A negative correlation found mRNA change ratio CIS. Conclusion findings suggest that enhanced may be related pathology depression Fkbp5, an regulator, mediates loss.

Language: Английский

Citations

0