Alcohol Use Disorder and the Gut–Brain Axis: A Narrative Review of the Role of Gut Microbiota and Implications for Treatment

Microorganisms, Journal Year: 2025, Volume and Issue: 13(1), P. 67 - 67

Published: Jan. 2, 2025

Alcohol use disorder (AUD) affects millions of people worldwide and can lead to deleterious physical social consequences. Recent research has highlighted not only the effect alcohol on gut microbiome, but also role microbiome gut-brain axis in development maintenance disorder. This review provides an overview reciprocal relationship between consumption including effects microbial composition, changes metabolites response consumption, how may modulate behavior. We discuss gut-mediated mechanisms neuroinflammation that contribute result from AUD, disruption intestinal barrier, toll-like receptor signaling, activation glial cells immune cells. Finally, we current evidence microbial-directed therapies for AUD implications this our understanding pathophysiology future directions.

Language: Английский

Associations of alcohol intake with gut microbiome: a prospective study in a predominantly low-income Black/African American population

American Journal of Clinical Nutrition, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский