Evidence of a persistent altered neural state in people with fibromyalgia syndrome during functional MRI studies and its relationship with pain and anxiety

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(1), P. e0316672 - e0316672

Published: Jan. 24, 2025

Altered neural signaling in fibromyalgia syndrome (FM) was investigated with functional magnetic resonance imaging (fMRI). We employed a novel fMRI network analysis method, Structural and Physiological Modeling (SAPM), which provides more detailed information than previous methods. The study involved brain data from participants FM (N = 22) control group (HC, N 18), acquired during noxious stimulation paradigm. analyses were supported by the brainstem spinal cord HC, provoked vestibulodynia (PVD), eye-tracking an of FM. results demonstrate differences connectivity, blood oxygenation-level dependent (BOLD) responses, between HC. In group, BOLD signals underwent large increase first 40 seconds each run, prior to application any stimuli, compared much smaller increases This indicates heightened state activity that is sustained runs, dissipates runs. exaggerated initial rise not observed PVD. Autonomic functioning differed groups. Pupil sizes larger groups exhibited pupil dilation same levels stimulation. varied relation trait anxiety scores. indicate people enter associated autonomic functioning, every concurrent increased sizes, pain sensitivity. These findings may relate well-known hypervigilance global hypersensitivity participants.

Language: Английский

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Understanding Non-Pharmacological Treatments for Fibromyalgia Functional and Well-Being Status: The Role of Literacy

Healthcare, Journal Year: 2024, Volume and Issue: 12(19), P. 1956 - 1956

Published: Sept. 30, 2024

Background/Objectives: Fibromyalgia (FM) affects up to 5% of the global population and is a leading cause significant social economic consequences. Higher health literacy leads better understanding treatment plans, improved self-care, adherence recommendations, enhancing overall quality life. This study aims determine whether different aspects disease are influenced by patients’ education level when applying same therapy assess how perceptions outcomes vary over time based on their educational level. Methods: involved 140 fibromyalgia patients diagnosed using 2016 ACR criteria, with 128 completing study. Participants attended three visits 28 weeks were stratified into four groups level: Group 1—secondary school or less; 2—high graduates; 3—college 4—university graduates. Patients assigned (n = 32, 30, 34, respectively) after initial evaluation (T0). The was assessed (T1) followed months later (T2) evaluate changes in functional status All underwent rehabilitation program, cognitive therapy, kinesiotherapy. Results: Significant differences impact patient’s life (FIQ total score) observed between from (p 0.000). FIQ score notably affected non-pharmacological higher education. These continued be even ended Functional limitations evident start 0.000) significantly post-treatment However, subjective evaluations (assessed first item FIQ) did not consistently align objective findings (hand grip strength). differ (F1Q1) across levels 0.045), inverse correlations noted SF-12 well-being components. Conclusions: underscores that enhances management outcomes, particularly combined therapies. may always improvements, indicating factors beyond education, such as personal external influences, also management. Thus, improving through interventions could further benefit FM

Language: Английский

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Neurosteroids as a possible new horizon in the treatment of fibromyalgia

Medical Hypotheses, Journal Year: 2024, Volume and Issue: 191, P. 111444 - 111444

Published: July 27, 2024

Language: Английский

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