Prevalence and associated factors of advanced HIV disease among ART-naïve and ART-experienced people with HIV at AHF-supported sites in Zambia DOI Creative Commons
Webster Chewe, Chitalu Chanda, Benson M. Hamooya

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 15, 2024

Abstract Background Individuals with advanced HIV disease (AHD) have a heightened risk of mortality despite access to antiretroviral therapy (ART). Sub-Saharan Africa (SSA) has disproportionate burden AHD-associated deaths. However, there is limited country-specific data on AHD’s and associated factors help design targeted interventions. Therefore, this study determined the prevalence AHD among ART-naïve ART-experienced adults at five AIDS Healthcare Foundation (AHF)-supported facilities in Zambia. Methodology We conducted cross-sectional 231 people living (PLHIV) collected demographic clinical using structured questionnaire. The primary outcome was AHD, defined as CD4 count less than 200 cells/µL VISITECT® point-of-care test. Multivariable logistic regression used assess AHD. Results Among participants, 59.7% were female, 54% aged 19–35 years. Most participants (79.2%), 85.3% classified WHO stage 1. 47.6% (110/231), significantly higher [51.9% (95/183)] compared [31.2% (15/48), p=0.011]. years exhibited notably (51.6%) those 13-18, 36-45, >45 (5.3%, 34.7%, 8.4%, respectively) had baseline viral load values (25,000 copies/mL vs. 9,690 copies/mL, p=0.037). Additionally, proportion individuals stages 2, 3, 4 without Across all included anemia (adjusted odds ratio [aOR] 3.03, 95% confidence interval [CI]: 1.15–7.97) being from New Masala Clinic health facility (aOR 3.79, CI: 1.17–12.30) Conclusion Advanced prevalent, particularly individuals, it location. There need for formulation interventions, especially PLHIV who are anemic. studies integrate diagnostics such test into routine care be resource-limited settings warranted early detection

Language: Английский

Prevalence and associated factors of advanced HIV disease among ART-naïve and ART-experienced people with HIV at AHF-supported sites in Zambia DOI Creative Commons
Webster Chewe, Chitalu Chanda, Benson M. Hamooya

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 15, 2024

Abstract Background Individuals with advanced HIV disease (AHD) have a heightened risk of mortality despite access to antiretroviral therapy (ART). Sub-Saharan Africa (SSA) has disproportionate burden AHD-associated deaths. However, there is limited country-specific data on AHD’s and associated factors help design targeted interventions. Therefore, this study determined the prevalence AHD among ART-naïve ART-experienced adults at five AIDS Healthcare Foundation (AHF)-supported facilities in Zambia. Methodology We conducted cross-sectional 231 people living (PLHIV) collected demographic clinical using structured questionnaire. The primary outcome was AHD, defined as CD4 count less than 200 cells/µL VISITECT® point-of-care test. Multivariable logistic regression used assess AHD. Results Among participants, 59.7% were female, 54% aged 19–35 years. Most participants (79.2%), 85.3% classified WHO stage 1. 47.6% (110/231), significantly higher [51.9% (95/183)] compared [31.2% (15/48), p=0.011]. years exhibited notably (51.6%) those 13-18, 36-45, >45 (5.3%, 34.7%, 8.4%, respectively) had baseline viral load values (25,000 copies/mL vs. 9,690 copies/mL, p=0.037). Additionally, proportion individuals stages 2, 3, 4 without Across all included anemia (adjusted odds ratio [aOR] 3.03, 95% confidence interval [CI]: 1.15–7.97) being from New Masala Clinic health facility (aOR 3.79, CI: 1.17–12.30) Conclusion Advanced prevalent, particularly individuals, it location. There need for formulation interventions, especially PLHIV who are anemic. studies integrate diagnostics such test into routine care be resource-limited settings warranted early detection

Language: Английский

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