Advances in the biosynthesis of naturally occurring benzylisoquinoline alkaloids

Frontiers in Plant Science, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 30, 2025

Benzylisoquinoline alkaloids (BIAs) are a prominent class of plant metabolites with significant pharmaceutical and industrial significance that have garnered substantial attention from researchers worldwide. BIAs exhibit several pharmacological activities been used extensively. Examples include analgesics such as morphine, tetrahydropalmatine, antimicrobials berberine, antineoplastic agents including cepharanthine. Most derived isolated medicinal plants; however, these plants predominantly wild resources scarce. Their high environmental impact, slow growth rate, scarcity resources, expensive direct extraction costs pose challenge. Certain present in trace amounts moreover, they complex chemical structures unstable properties. Designing synthesis routes processes is challenging. Thus, major obstacle developing utilizing natural products the industry lies their low abundance nature. Consequently, limited supply molecules fails to meet research market demands. In recent years, biosynthesis approaches emerged novel efficient method obtain BIAs. this review, progress field enzymes related elucidation biosynthetic pathways discussed, future perspectives for designing viable strategies targeted manipulation presented.

Language: Английский

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Developing an efficient protocol for hairy root transformation of Corydalis saxicola

Plant Cell Tissue and Organ Culture (PCTOC), Journal Year: 2025, Volume and Issue: 160(2)

Published: Jan. 23, 2025

Language: Английский

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Characterization of Metabolites and Transcriptome of Pepper Accessions from Four Southern Provinces of China

Genes, Journal Year: 2025, Volume and Issue: 16(2), P. 137 - 137

Published: Jan. 24, 2025

Background/Objectives: Pepper (Capsicum annuum L.) is a widely grown vegetable and spice crop worldwide. This study aims to reveal the differences of metabolites among pepper accessions from different regions explore candidate genes related pepper. Methods: The metabolome transcriptome 36 were determined by targeted metabolomics analysis RNA sequencing technology, differential C. four important production consumption provinces China, Hunan, Guizhou, Yunnan Sichuan, analyzed. Results: Flavonoids are main characteristic that distinguish Yun_Gui_Chuan Group Hunan Group. aglycones flavonoids in each group different; mainly luteolin, quercetin, chrysoeriol isorhamnetin; apigenin. Transcriptome data showed two flavonoid 3′-monooxygenase differed significantly between groups chili peppers, we speculated they may be core enzymes regulating their profile. And an SNP mutation located gene Cgla06g001871 strong correlation with Group, which can used as DNA marker identify provide support for regional specialty variety conservation. In addition, also analyzed taste nutrition provinces, results sugar content Guizhou was low capsaicinoids Sichuan low, while no significant difference found acid vitamin contents provinces. Conclusions: China determined, expressed province

Language: Английский

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An autotetraploid genome of <i>Corydalis sheareri</i> provides insight into the evolution and benzylisoquinoline alkaloids diversity of <i>Corydalis</i>

Published: Jan. 1, 2025

Language: Английский

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