Journal of Clinical Biochemistry and Nutrition,
Journal Year:
2024,
Volume and Issue:
76(2), P. 195 - 201
Published: Nov. 6, 2024
Although
we
previously
reported
that
2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one
has
antioxidant
properties,
its
effect
on
the
skin
remains
unclear.
This
study
aimed
to
investigate
effects
of
beverages
containing
moisture.
enrolled
220
healthy
Japanese
participants
with
dry
who
were
randomly
assigned
test
or
placebo
group
(n
=
110
each).
Each
received
either
a
beverage
for
12
weeks.
The
primary
outcome
was
stratum
corneum
water
content.
Secondary
outcomes
transdermal
loss,
number
blemishes
and
wrinkles,
blood
markers
such
as
biological
potential
diacron-reactive
oxygen
metabolites.
Visual
analog
scale
used
assess
improvement.
Stratum
content
visual
scores
differed
significantly
between
groups.
Water
increased
in
compared
at
4
8
Subjective
symptoms
improved
intake
placebo.
No
other
significant
adverse
observed.
In
conclusion,
2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one-containing
consecutive
weeks
increases
findings
could
aid
development
safe
functional
foods
enriched
this
compound.
Biomolecules,
Journal Year:
2025,
Volume and Issue:
15(3), P. 394 - 394
Published: March 10, 2025
Most
eukaryotic
and
prokaryotic
cells
have
the
potential
to
secrete
a
group
of
structures/membrane-bound
organelles,
collectively
referred
as
extracellular
vesicles
(EVs),
which
offer
several
advantages
producer/receiver
cells.
This
review
provides
an
overview
EVs
from
plant
sources
with
emphasis
on
their
health-promoting
possible
use
therapeutic
agents.
highlights
essential
biological
effects
plant-derived
vesicles,
including
immune
modulation,
anticancer
activities,
protection
against
chemical
toxicity
pathogens,
well
anti-aging,
anti-melanogenesis,
anti-arthritic
effects,
along
ongoing
clinical
studies.
Evidence
revealed
that
EVs’
contents
exert
beneficial
properties
through
regulating
important
signaling
pathways
by
transferring
miRNAs
other
components.
Taken
all
together,
data
proposed
can
be
utilized
nutritional
compounds
agents,
such
drug
carriers.
However,
this
emerging
research
area
requires
further
in
vitro/in
vivo
studies
trials
determine
exact
underlying
mechanisms
positive
health
treating
various
diseases.
Journal of Gazi University Health Sciences Institute,
Journal Year:
2025,
Volume and Issue:
7(1), P. 19 - 27
Published: April 30, 2025
Plant-derived
exosome-like
vesicles
(PELVs)
are
nanometer-sized
particles
comprising
proteins,
lipids,
nucleic
acids,
and
small
molecule
substances
generated
from
plants.
PELVs
have
many
advantages,
such
as
low
toxicity,
efficient
cellular
uptake,
high
biocompatibility,
stability,
large-scale
production.
can
regulate
intercellular
communication
by
releasing
their
contents,
including
mRNA,
miRNA,
proteins.
(PDELVs)
attracted
considerable
attention
in
scientific
research
owing
to
promising
therapeutic
effects
researches
assessed
the
extensive
potential
of
PDELVs
treatment
various
diseases
cancer
treatment.
They
exhibit
clinical
attributes
benefits
over
conventional
pharmaceuticals.
This
mini-review
aims
summarize
categorize
main
paths
followed
scientists
working
with
PDELNs
for
therapy.
Current Issues in Molecular Biology,
Journal Year:
2025,
Volume and Issue:
47(3), P. 144 - 144
Published: Feb. 22, 2025
Exosome-like
nanovesicles
(ELNs)
derived
from
natural
products
are
gaining
attention
as
innovative
therapeutic
agents
due
to
their
biocompatibility,
low
immunogenicity,
and
capability
transport
bioactive
molecules
such
proteins,
lipids,
nucleic
acids.
These
plant-derived
ELNs
exhibit
structural
similarities
with
mammalian
exosomes,
making
them
suitable
for
drug
delivery,
microbiome-targeted
therapies,
regenerative
medicine.
Recent
studies
highlight
potential
in
treating
cancer,
inflammation,
metabolic
disorders.
Additionally,
have
applications
cosmetics,
agriculture,
the
food
industry.
This
review
combines
latest
advancements
research
on
ELNs,
focusing
isolation
techniques,
pharmacological
effects,
applications.
Although
offer
promising
opportunities,
several
challenges
must
be
addressed,
including
standardization,
large-scale
production,
vivo
efficacy.
By
summarizing
cutting-edge
suggesting
future
directions,
we
aim
inspire
further
development
of
next-generation
platforms.
Medical Oncology,
Journal Year:
2025,
Volume and Issue:
42(4)
Published: March 17, 2025
Abstract
Glioblastoma
is
the
most
common
and
highly
invasive
glial
tumor,
significantly
reducing
patient
survival.
Current
therapeutic
approaches
have
limited
success
rates.
Plant-derived
nanovesicles
are
a
rapidly
developing
area,
recognized
for
their
exceptional
biofunctional
properties,
emerging
as
promising
approach
in
cancer
treatment.
The
present
study
focuses
on
isolation
of
from
Viburnum
opulus
fruits
using
cost-effective
method
that
includes
polymer-based
exosome
precipitation
buffer
size
exclusion
chromatography,
followed
by
characterization.
Morphological
analysis
via
Field
Emission
Scanning
Electron
Microscopy
Transmission
revealed
ranging
oval
to
elliptical
shapes,
with
average
diameters
54.23
nm
41.21
nm,
respectively.
Dynamic
light
scattering
determined
45.36
indicating
presence
nanovesicles,
zeta
potential
was
−
2.87
mV.
Biochemical
characterization
showed
total
protein
phenolic
concentrations
1534
±
97.78
µg/ml
4.270
0.66
mg
gallic
acid
equivalents/L,
respectively,
antioxidant
status
values
3.83
0.37
mmol
Trolox
equivalents/L.
Based
IC50
values,
these
were
7.5
times
more
toxic
U87MG
human
glioblastoma
cells
compared
healthy
dermal
fibroblasts.
Analyses
including
clonogenic
cell
survival,
wound
healing,
apoptosis,
status,
oxidant
continued
only
cells,
fibroblasts
low
response
nanovesicle
Qualitative
quantitative
assessments
demonstrated
-derived
effectively
inhibited
proliferation
migration.
Due
non-toxic,
anticancer,
hold
significant
management.
Graphical
abstract
