Mechanisms of extracellular vesicle uptake and implications for the design of cancer therapeutics DOI Creative Commons
Stephanie R. Jackson, Joseph P. Flemming,

Kübra Karagoz

et al.

Journal of Extracellular Biology, Journal Year: 2024, Volume and Issue: 3(11)

Published: Oct. 30, 2024

The translation of pre-clinical anti-cancer therapies to regulatory approval has been promising, but slower than hoped. While innovative and effective treatments continue achieve or seek approval, setbacks are often attributed a lack efficacy, failure clinical endpoints, dose-limiting toxicities. Successful efforts have characterized by the development therapeutics designed specifically deliver optimal dosing tumour cells while minimizing off-target toxicity. Much effort devoted rational design application synthetic nanoparticles serve as targeted therapeutic delivery vehicles. Several challenges successful this modality vehicles include induction protracted immune response that results in their rapid systemic clearance, manufacturing cost, stability, biocompatibility. Extracellular vesicles (EVs) heterogeneous class endogenous biologically produced lipid bilayer mediate intercellular communication carrying bioactive macromolecules capable modifying cellular phenotypes local distant cells. By genetic, chemical, metabolic methods, extracellular can be engineered display targeting moieties on surface transporting specific cargo modulate pathological processes following uptake target cell populations. This review will survey types EVs, composition cargoes, strategies employed increase targeting, uptake, release, potential

Language: Английский

Oxidative Score and Microvesicle Profile Suggest Cardiovascular Risk in Chronic Kidney Disease DOI Creative Commons

Gemma Valera-Arévalo,

María del Mar Rodríguez-San Pedro,

Paula Jara

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(2), P. 178 - 178

Published: Feb. 3, 2025

Chronic kidney disease (CKD) is associated with a high incidence of cardiovascular (CVD) due to the accumulation uremic toxins, altered redox state, and chronic systemic inflammation. This study aimed analyze relationship between status patients CKD phenotype microvesicles (MVs) subtypes, events. The oxidative stress level each participant was determined using an individualized OXY-SCORE. pro-oxidant antioxidant parameters expression membrane markers in endothelial-derived (EMVs) platelet-derived (PMVs) established. Patients advanced (ACKD) hemodialysis (HD) had higher OXY-SCORE than healthy subjects (HS), whereas peritoneal dialysis (PD) similar scores HS. PD showed elevated PMVs CD41 expression, HD EMVs CD31 expression. ACKD tissue factor (TF) EMVs. TF correlated xanthine oxidase (XO) activity negatively parameters. events show TF. In conclusion, may serve as risk CKD, being potential predictive prognostic biomarkers CVD.

Language: Английский

Citations

0
Mechanisms of extracellular vesicle uptake and implications for the design of cancer therapeutics DOI Creative Commons
Stephanie R. Jackson, Joseph P. Flemming,

Kübra Karagoz

et al.

Journal of Extracellular Biology, Journal Year: 2024, Volume and Issue: 3(11)

Published: Oct. 30, 2024

The translation of pre-clinical anti-cancer therapies to regulatory approval has been promising, but slower than hoped. While innovative and effective treatments continue achieve or seek approval, setbacks are often attributed a lack efficacy, failure clinical endpoints, dose-limiting toxicities. Successful efforts have characterized by the development therapeutics designed specifically deliver optimal dosing tumour cells while minimizing off-target toxicity. Much effort devoted rational design application synthetic nanoparticles serve as targeted therapeutic delivery vehicles. Several challenges successful this modality vehicles include induction protracted immune response that results in their rapid systemic clearance, manufacturing cost, stability, biocompatibility. Extracellular vesicles (EVs) heterogeneous class endogenous biologically produced lipid bilayer mediate intercellular communication carrying bioactive macromolecules capable modifying cellular phenotypes local distant cells. By genetic, chemical, metabolic methods, extracellular can be engineered display targeting moieties on surface transporting specific cargo modulate pathological processes following uptake target cell populations. This review will survey types EVs, composition cargoes, strategies employed increase targeting, uptake, release, potential

Language: Английский

Citations

2