Recent advances on gene-related DNA methylation in cancer diagnosis, prognosis, and treatment: a clinical perspective DOI Creative Commons
Alessandro Lavoro,

Daria Ricci,

Giuseppe Gattuso

et al.

Clinical Epigenetics, Journal Year: 2025, Volume and Issue: 17(1)

Published: May 5, 2025

Abstract Recent advances in screening programs and the development of innovative therapeutic strategies have significantly improved clinical outcomes cancer patients. However, many patients still experience treatment failure, primarily due to inherent or acquired drug resistance mechanisms. This challenge underscores urgent need for novel targets effective malignancies, as well cancer-specific biomarkers enhance early diagnosis guide interventions. Epigenetic mechanisms, including DNA methylation, recently garnered growing interest key regulators gene expression under both physiological pathological conditions. Although epigenetic dysregulations are reliable tumor hallmarks, methylation is not routinely integrated into practice, highlighting further research translate preclinical findings from bench bedside. On these bases, present review aims illustrate state art regarding role cancer, describing technologies currently available profiling. Furthermore, latest evidence on application hotspots prognosis, impact epidrugs care, discussed provide a comprehensive overview potential relevance advancing personalized medicine.

Language: Английский

Abnormal epigenetic modification of lysosome and lipid regulating genes in Alzheimer’s disease DOI Creative Commons

Tingting Ruan,

Yunxiang Ling,

Can Wu

et al.

Journal of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown

Published: March 28, 2025

Background Abnormal lipid metabolism has been identified as a potential pathogenic mechanism of Alzheimer's disease (AD), which might be epigenetically regulated. Lysosomes are critical organelles for metabolism. However, the epigenetic modifications lysosome and regulating genes remain unclear in AD patients. Objective Explore role abnormal modifications, especially methylation metabolism-related AD. Methods Methylation beadchip MALDI-TOF mass spectrometry were used to detect genome-wide DNA levels validate key gene methylation, respectively. Clinical data collected from all participants. Associations between clinical biochemical characteristics altered patients analyzed, risk factor model was established. Results 41 differentially methylated positions (DMPs) corresponding 33 patients, with 18 hypermethylated 23 hypomethylated positions. Significant alterations observed ( CTNNB1, DGKQ, SLC27A1 ) lysosomal transmembrane TMEM175 ). analysis revealed that TP, ALB, IB, ADA, ALP, HCY, GLU, TC, BUN, HDL-C, LDL-C, APOA1 significantly higher whereas A/G DB lower. hypermethylation further verified found correlate APOA1, HCY. The AUC model, integrated markers reached 0.9519 p < 0.0001). Conclusions regulation dyshomeostasis high-risk factors processes pathogenesis.

Language: Английский

Citations

1
Recent advances on gene-related DNA methylation in cancer diagnosis, prognosis, and treatment: a clinical perspective DOI Creative Commons
Alessandro Lavoro,

Daria Ricci,

Giuseppe Gattuso

et al.

Clinical Epigenetics, Journal Year: 2025, Volume and Issue: 17(1)

Published: May 5, 2025

Abstract Recent advances in screening programs and the development of innovative therapeutic strategies have significantly improved clinical outcomes cancer patients. However, many patients still experience treatment failure, primarily due to inherent or acquired drug resistance mechanisms. This challenge underscores urgent need for novel targets effective malignancies, as well cancer-specific biomarkers enhance early diagnosis guide interventions. Epigenetic mechanisms, including DNA methylation, recently garnered growing interest key regulators gene expression under both physiological pathological conditions. Although epigenetic dysregulations are reliable tumor hallmarks, methylation is not routinely integrated into practice, highlighting further research translate preclinical findings from bench bedside. On these bases, present review aims illustrate state art regarding role cancer, describing technologies currently available profiling. Furthermore, latest evidence on application hotspots prognosis, impact epidrugs care, discussed provide a comprehensive overview potential relevance advancing personalized medicine.

Language: Английский

Citations

0