Targeted lipidomics analysis of possible molecular mechanisms of lipid changes in temporal lobe epilepsy models
Huaiyu Sun,
No information about this author
Xuewei Li,
No information about this author
Zhiqing Chen
No information about this author
et al.
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
15
Published: Jan. 9, 2025
Lipids
are
vital
biomolecules
involved
in
the
formation
of
various
biofilms.
Seizures
can
cause
changes
lipid
metabolism
brain.
In-depth
studies
at
multiple
levels
urgently
needed
to
elucidate
composition,
distribution,
and
metabolic
pathways
brain
after
seizure.
In
this
research,
a
cutting-edge
targeted
quantitative
lipidomics
study
was
conducted
on
hippocampal
tissues
six
rats
with
temporal
lobe
epilepsy
normal
rats.
Accurate
quantification
based
linear
equations
calculated
using
an
internal
standard.
The
lipids
were
quantitatively
qualitatively
analyzed
by
ultra-high
performance
liquid
chromatography
(UPLC)
mass
spectrometry
(MS).
A
total
21
classes
identified.
Among
them,
most
abundant
triacylglycerol
(TG),
phosphatidyl
ethanolamine
(PE-P),
fatty
acids
(FA).
Cholesteryl
ester
(ChE)
exhibits
considerable
difference
between
epileptic
samples.
ChE
found
be
significantly
upregulated
lipid,
while
FA
observed
downregulated
lipid.
Based
absolute
analysis
rat
specimens,
contents
change
trends
different
observed.
Upregulation
dihydroceramide
(DHCer)
observed,
distribution
elucidated
causes
possible
molecular
mechanisms
accumulation
epilepsy.
results
methods
described
provide
comprehensive
new
therapeutic
target
for
treatment
Language: Английский
Epilepsy–heart syndrome: Concept, clinical context, and opportunity for integrated care
Epilepsia,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 13, 2025
Abstract
In
this
concept
paper,
we
introduce
epilepsy‐heart
syndrome
as
a
shared
burden
of
illness
between
epilepsy
and
cardiac
disorders.
This
pragmatic
definition
is
agnostic
which
condition
came
first
(the
or
the
disorder),
recognising
that
these
conditions
can
each
serve
risk
factor
for
other
owing
to
bidirectional
relationship
exists
brain
heart.
To
provide
clinical
context,
include
ictal
asystole
an
example
phenotype
syndrome.
We
highlight
evidence
patients
with
coming
harm
failure
integrated
care
neurology
cardiology.
underscores
unmet
need
collaborative
address
this,
propose
framework
care,
drawing
upon
our
own
centre's
recently
established
successful
multidisciplinary
team
meeting
(MDT)
neurologists
cardiologists,
joint
cardiology‐neurology
PhD
programme,
work
developing
national
guideline
on
management
Association
British
Neurologists
(ABN)
Heart
Rhythm
Society
(BHRS).
Language: Английский
MicroRNAs as Epigenetic Biomarkers of Pathogenetic Mechanisms of the Metabolic Syndrome Induced by Antiseizure Medications: Systematic Review
N. А. Shnayder,
No information about this author
Nikolai A. Pekarets,
No information about this author
Natalia I. Pekarets
No information about this author
et al.
Journal of Clinical Medicine,
Journal Year:
2025,
Volume and Issue:
14(7), P. 2432 - 2432
Published: April 2, 2025
Antiseizure
medication
(ASM)
induced
metabolic
syndrome
(AIMetS)
is
a
common
adverse
drug
reaction
(ADR)
of
pharmacotherapy
for
epilepsy
and
psychiatric
disorders.
However,
the
sensitivity
specificity
blood
biomarkers
may
be
insufficient
due
to
influence
combined
pathology,
concomitant
diseases,
peculiarities
metabolism
ASMs
in
patients
with
epilepsy.
Methods:
The
presented
results
experimental
clinical
studies
microRNAs
(miRs)
as
epigenetic
MetS
AIMetS,
which
were
entered
into
different
databases,
analyzed
last
decade
(2014-2024).
Results:
A
systematic
review
demonstrated
that
miRs
can
act
promising
key
AIMetS
domains.
variable
role
various
their
paralogs
pathogenesis
AIMetS.
Therefore,
part
this
study,
an
signature
was
proposed
allows
us
assess
risk
developing
severity
low
risk,
medium
high
risk.
Conclusions:
mechanisms
development
are
actual
problem
epileptology,
still
far
from
being
resolved.
panels
(signatures)
widespread
ADR
help
increase
safety
circulating
it
necessary
conduct
"bridge"
order
replicate
preclinical
real
practice.
Language: Английский
A personalized approach to the diagnosis of epilepsy in obese children
Laboratory Service,
Journal Year:
2025,
Volume and Issue:
14(1), P. 5 - 5
Published: April 8, 2025
Introduction.
Epilepsy
is
one
of
the
important
problems
modern
neurology.
Various
epileptic
syndromes
can
be
combined
with
other
diseases,
in
particular,
obesity.
Currently,
various
aspects
etiopathogenesis
seizures
against
background
obesity
are
actively
studied.
The
aim
work
to
develop
an
approach
personalized
biochemical
diagnostics
epilepsy
children
based
on
potential
changes
profile
organic
acids
urine.
Materials
and
methods.
study
included
22
patients
aged
1
16
years
(mean
age
11.7
years):
6
comparison
group.
HPLC-MS.
Results
carried
out
60
In
group
obesity,
excess
upper
reference
limit
a
number
markers
Krebs
cycle
(fumaric
2-ketoglutaric
acids),
bacterial
dysbiosis
lactic
acid
were
detected.
Also
patient
sample,
contrast
group,
increase
level
mitochondrial
dysfunction
was
found.
Results.
exceeded.
sample
patients,
Conclusion.
Thus,
we
identified
metabolic
associated
Language: Английский