A Principled Framework for Mendelian Randomization in Oral Health Research DOI Creative Commons
Nasir Zeeshan Bashir, Mario Romandini, Moritz Kebschull

et al.

Journal of Periodontal Research, Journal Year: 2025, Volume and Issue: unknown

Published: May 9, 2025

ABSTRACT In recent years, the popularity of Mendelian randomization (MR) as a technique to investigate causal relationships has grown exponentially. This approach leverages randomness inherent in allocation genetic variants circumvent issues unobserved confounding and reverse causation that compromise many claims based on observational data. this manuscript, key assumptions required for MR analyses yield credible inferences are reviewed. It is emphasized even technically rigorous may implausible conclusions if these violated. The goal provide readers from nonstatistical backgrounds with clear understanding foundational underpinning MR, complemented by detailed discussion specific considerations oral health research, particularly when periodontitis used exposure or outcome. As any study design, appropriate can compelling evidence causality certain contexts, while its application be unwarranted others. methodological article aims equip tools critically assess findings, distinguish scenarios where use justified, understand steps correct execution reporting. A checklist assessing credibility investigations also provided.

Language: Английский

Genetic risk factors for periodontitis: a genome-wide association study using UK Biobank data DOI Creative Commons
Chenyi Gao, Mark M. Iles, D. Timothy Bishop

et al.

Clinical Oral Investigations, Journal Year: 2025, Volume and Issue: 29(2)

Published: Feb. 14, 2025

Language: Английский

Citations

0
Genetic Biomarkers for Periodontal Diseases: A Systematic Review DOI Creative Commons
Henrik Dommisch, Daniela Hoedke, Emily Ming‐Chieh Lu

et al.

Journal Of Clinical Periodontology, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

ABSTRACT Aims To identify genetic biomarkers that may be used in the diagnosis, prevention or management of different forms periodontal disease. Materials and Methods Following protocol registration PICOTS (patient, intervention, comparison, outcome, time, studies) questions, a systematic search literature was conducted (PudMed, Ovid), resulting 1592 papers screened by two reviewers. Diagnostic data were extracted calculated from included compared with clinically determined diagnoses, disease progression and/or response to treatment. Results A total 607 articles met inclusion criteria, including 10 reporting on gingivitis 597 periodontitis. Only reported diagnostic performance data, while for 41 large candidate gene studies, could data. No study using chair‐side tests identified. Low moderate values sensitivity, specificity, positive negative predictive value accuracy found. Conclusion test clinical emerged prediction resolution. Thus, potential future applications polygenic risk scores encode susceptibility, as well single‐marker testing monogenic oligogenic diseases, are discussed.

Language: Английский

Citations

0
Exploring the Association Between GSTP1 Single Nucleotide Polymorphisms and Periodontitis: A Systematic Review DOI
Manju Krishnan,

Anitha Balaji,

Prabhu Manickam Natarajan

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Abstract Periodontitis is a multifactorial disease influenced by genetic and environmental factors. Glutathione S-Transferase P1 (GSTP1) gene polymorphisms, known for their role in oxidative stress inflammation, have been investigated association with periodontitis. This systematic review aims to evaluate the relationship between GSTP1 single nucleotide polymorphisms (SNPs) periodontitis across various study designs. A comprehensive search was conducted PubMed, EMBASE, Scopus, Cochrane Library case-control, cohort, cross-sectional, vitro studies, randomized controlled trials (RCTs) examining SNPs Studies included human subjects diagnosed periodontal diseases, assessing variants relation parameters markers. The selection followed rigorous inclusion exclusion criteria, quality assessment performed using PRISMA guidelines. Numerous studies identified associations GST periodontitis, particularly younger populations non-smokers, GSTM1 null allele, GSTT1 presence, mutant allele emerging as significant risk are consistently findings reveal complex sometimes contradictory relationship. Future research should focus on addressing these gaps enhance our understanding of basis develop targeted prevention treatment strategies.

Language: Английский

Citations

0
A Principled Framework for Mendelian Randomization in Oral Health Research DOI Creative Commons
Nasir Zeeshan Bashir, Mario Romandini, Moritz Kebschull

et al.

Journal of Periodontal Research, Journal Year: 2025, Volume and Issue: unknown

Published: May 9, 2025

ABSTRACT In recent years, the popularity of Mendelian randomization (MR) as a technique to investigate causal relationships has grown exponentially. This approach leverages randomness inherent in allocation genetic variants circumvent issues unobserved confounding and reverse causation that compromise many claims based on observational data. this manuscript, key assumptions required for MR analyses yield credible inferences are reviewed. It is emphasized even technically rigorous may implausible conclusions if these violated. The goal provide readers from nonstatistical backgrounds with clear understanding foundational underpinning MR, complemented by detailed discussion specific considerations oral health research, particularly when periodontitis used exposure or outcome. As any study design, appropriate can compelling evidence causality certain contexts, while its application be unwarranted others. methodological article aims equip tools critically assess findings, distinguish scenarios where use justified, understand steps correct execution reporting. A checklist assessing credibility investigations also provided.

Language: Английский

Citations

0