Unravelling the Molecular Footprints of Diabetic Foot Ulcers: In Silico Discovery of Key Protein and MicroRNA Signatures DOI Creative Commons
Jay Mukesh Chudasama, Ghanshyam Parmar

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 12, 2024

Abstract Diabetic foot ulcers (DFUs) present a significant clinical challenge, characterized by chronic inflammation and impaired wound healing. This study employs Gene Ontology (GO) analysis to identify critical biological processes, molecular functions, cellular components, pathways associated with DFUs, aiming uncover novel therapeutic targets. The reveals enrichment in processes such as Positive Regulation of miRNA Transcription Transcription, highlighting the crucial role microRNAs, including hsa-miR-34a-5p, hsa-miR-155-5p, hsa-miR-17-5p, hsa-miR-29b-3p, hsa-miR-7-5p, hsa-miR-1-3p, hsa-miR-23b-3p, regulating healing inflammation. Enriched DNA-binding Activator Activity Protein Phosphatase Binding, suggest that targeting genes like TP53, GAPDH, AKT1, MYC, TNF, EGFR, STAT3, FN1, VEGFA, JUN could modulate improve DFU management. also identifies key Vesicle Platelet Alpha Granule Lumen, for transport signaling, suggesting interventions these components enhance repair. Furthermore, enriched Proteoglycans Cancer Human Cytomegalovirus Infection indicate potential mechanisms viral influences relevant DFUs. These findings provide comprehensive framework developing targeted therapies address multifaceted pathology offering promising avenues improving patient outcomes advancing strategies.

Language: Английский

Unravelling the Molecular Footprints of Diabetic Foot Ulcers: In Silico Discovery of Key Protein and MicroRNA Signatures DOI Creative Commons
Jay Mukesh Chudasama, Ghanshyam Parmar

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 12, 2024

Abstract Diabetic foot ulcers (DFUs) present a significant clinical challenge, characterized by chronic inflammation and impaired wound healing. This study employs Gene Ontology (GO) analysis to identify critical biological processes, molecular functions, cellular components, pathways associated with DFUs, aiming uncover novel therapeutic targets. The reveals enrichment in processes such as Positive Regulation of miRNA Transcription Transcription, highlighting the crucial role microRNAs, including hsa-miR-34a-5p, hsa-miR-155-5p, hsa-miR-17-5p, hsa-miR-29b-3p, hsa-miR-7-5p, hsa-miR-1-3p, hsa-miR-23b-3p, regulating healing inflammation. Enriched DNA-binding Activator Activity Protein Phosphatase Binding, suggest that targeting genes like TP53, GAPDH, AKT1, MYC, TNF, EGFR, STAT3, FN1, VEGFA, JUN could modulate improve DFU management. also identifies key Vesicle Platelet Alpha Granule Lumen, for transport signaling, suggesting interventions these components enhance repair. Furthermore, enriched Proteoglycans Cancer Human Cytomegalovirus Infection indicate potential mechanisms viral influences relevant DFUs. These findings provide comprehensive framework developing targeted therapies address multifaceted pathology offering promising avenues improving patient outcomes advancing strategies.

Language: Английский

Citations

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