Advances in colorectal cancer screening and detection: a narrative review on biomarkers, imaging and preventive strategies

Journal of the Egyptian National Cancer Institute, Journal Year: 2025, Volume and Issue: 37(1)

Published: April 11, 2025

Abstract Background With the third incident rate and a second mortality rate, colorectal cancer (CRC) continues to be one of most prevalent deadly malignancies worldwide. Adenomas usually develop into adenocarcinomas in (CRC), process that can halted by early detection prevention care. Main body Faecal immunochemical testing (FIT) endoscopies are examples current screening tools dramatically lower incidence death cancer. Current development centre on non-invasive methods provide better accuracy dangers, such as blood-based liquid biopsies imaging modalities like CT MR colonography. For detection, biopsies—especially those using methylated DNA tests SEPT9—offer encouraging outcomes. Circulating tumour (ctDNA) has emerged crucial biomarker, increasing identification therapy monitoring. Proteomic metabolic indicators further improve figuring out who is at high risk keeping an eye for recurrence. The rates polyps have increased due advancements technologies artificial intelligence (AI), narrow-band (NBI), high-definition colonoscopy. emphasis been preventive measures, chemoprevention lifestyle modifications, dietary fibre, regular exercise, chemoprotective drugs aspirin demonstrated potential lowering There still issues with global implementation screening, including differences access between socioeconomic racial groups. Hope more individualized efficient CRC provided new research biomarkers technological polygenic classification. Conclusion variety invasive techniques available identify early. To enhance prognosis mortality, undergone tremendous advancement. Although colonoscopy faecal assays good standards detecting advances biopsy, proteomics, transformed field offered less invasive, precise choices, surveillance, circulating other show potential.

Language: Английский

Exploring the Molecular Pathways of Advanced Rectal Cancer: A Focus on Genetic, RNA, and Biological Technique

Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: unknown, P. 155956 - 155956

Published: April 1, 2025

Language: Английский