Branched-Chain Amino Acids and Inflammation Management in Endurance Sports: Molecular Mechanisms and Practical Implications DOI Open Access

Miaomiao Xu,

Danhong Hu,

Xiaoguang Liu

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(8), P. 1335 - 1335

Published: April 12, 2025

Endurance athletes frequently experience muscle damage and inflammation due to prolonged, high-intensity exercise, which can impair recovery hinder performance. This review examines the role of branched-chain amino acid (BCAA) supplementation in repair, modulation, immune regulation. BCAAs—particularly leucine isoleucine—activate key molecular pathways, including mechanistic target rapamycin (mTOR) AMP-activated protein kinase (AMPK), promote synthesis enhance energy metabolism. They also attenuate inflammatory responses by modulating nuclear factor kappa-light-chain-enhancer activated B cells (NF-κB), mitogen-activated (MAPK), Janus kinase/signal transducer activator transcription (JAK/STAT) reducing levels tumor necrosis factor-alpha (TNF-α) interleukin-6 (IL-6). In addition, BCAAs influence function via complex 1 (mTORC1) signaling, autophagy, mitigate exercise-induced apoptosis. These effects result reduced soreness, lower biomarker (e.g., creatine kinase, lactate dehydrogenase), improved recovery. Practical considerations such as optimal dosage, timing, co-supplementation with carbohydrates, proteins, or omega-3s are addressed. While show promise a nutritional strategy for enhancing controlling endurance athletes, further research is needed refine personalized protocols clarify long-term effects.

Language: Английский

Effect of Different Cold acclimation Methods on the Exercise Capacity of Mice in Low-Temperature Environments DOI

Xue Geng,

Zuotian Li,

Chaoyi Qu

et al.

Journal of Thermal Biology, Journal Year: 2025, Volume and Issue: 127, P. 104050 - 104050

Published: Jan. 1, 2025

Language: Английский

Citations

0
Combined Effects of Spirulina Liquid Extract and Endurance Training on Aerobic Performance and Muscle Metabolism Adaptation in Wistar Rats DOI Open Access
Jordi Vignaud, Céline Loiseau,

Martine Côme

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(2), P. 283 - 283

Published: Jan. 14, 2025

Background: Physical activity, such as running, protects against cardiovascular disease and obesity but can induce oxidative stress. Athletes often consume antioxidants to counteract the overproduction of reactive oxygen nitrogen species during exercise. Spirulina, particularly its phycocyanin content, activates Nrf2 pathway, stimulating antioxidant responses. Studies show that enhances defenses reduces inflammation, potentially improving muscle adaptation recovery. This study evaluates a Spirulina liquid extract (SLE) supplementation endurance training, hypothesizing improves oxidant status performance in soleus extensor digitorum longus muscles. Methods: Three-week-old male Wistar rats were divided into four groups: sedentary control group (C), supplemented with SLE (SP), an training (T), (SPT). After 8 weeks treadmill blood collected. Biochemical parameters gene expression analyses performed assess effects supplementation. Results: The maximal aerobic speed improved significantly SPT group. Plasma lipid profiles showed reduction triglyceridemia, cholesterolemia, atherogenic index trained groups, especially Muscle malondialdehyde levels decreased compared T. Gene analysis revealed upregulation mitochondrial biogenesis genes both muscles, differences between groups for related glycogen storage β-oxidation. Conclusions: demonstrated enhanced exercise promoted molecular adaptations. These findings suggest promising functional food supplement athletes, optimizing recovery performance.

Language: Английский

Citations

0
Collagen type III resists UVB induced photoaging of HaCaT cells by regulating mTOR signaling pathway DOI

Helei Liu,

Hao Li,

Pengwei Zhao

et al.

Journal of Photochemistry and Photobiology B Biology, Journal Year: 2025, Volume and Issue: unknown, P. 113153 - 113153

Published: April 1, 2025

Language: Английский

Citations

0
Branched-Chain Amino Acids and Inflammation Management in Endurance Sports: Molecular Mechanisms and Practical Implications DOI Open Access

Miaomiao Xu,

Danhong Hu,

Xiaoguang Liu

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(8), P. 1335 - 1335

Published: April 12, 2025

Endurance athletes frequently experience muscle damage and inflammation due to prolonged, high-intensity exercise, which can impair recovery hinder performance. This review examines the role of branched-chain amino acid (BCAA) supplementation in repair, modulation, immune regulation. BCAAs—particularly leucine isoleucine—activate key molecular pathways, including mechanistic target rapamycin (mTOR) AMP-activated protein kinase (AMPK), promote synthesis enhance energy metabolism. They also attenuate inflammatory responses by modulating nuclear factor kappa-light-chain-enhancer activated B cells (NF-κB), mitogen-activated (MAPK), Janus kinase/signal transducer activator transcription (JAK/STAT) reducing levels tumor necrosis factor-alpha (TNF-α) interleukin-6 (IL-6). In addition, BCAAs influence function via complex 1 (mTORC1) signaling, autophagy, mitigate exercise-induced apoptosis. These effects result reduced soreness, lower biomarker (e.g., creatine kinase, lactate dehydrogenase), improved recovery. Practical considerations such as optimal dosage, timing, co-supplementation with carbohydrates, proteins, or omega-3s are addressed. While show promise a nutritional strategy for enhancing controlling endurance athletes, further research is needed refine personalized protocols clarify long-term effects.

Language: Английский

Citations

0