A Narrative Review on Biochemical Markers and Emerging Treatments in Prodromal Synucleinopathies DOI Creative Commons
Jamir Pitton Rissardo, Ana Letícia Fornari Caprara

Clinics and Practice, Journal Year: 2025, Volume and Issue: 15(3), P. 65 - 65

Published: March 17, 2025

Alpha-synuclein has been associated with neurodegeneration, especially in Parkinson’s disease (PD). This study aimed to review clinical, biochemical, and neuroimaging markers management of prodromal synucleinopathies. The state synucleinopathies can be better understood PD pathophysiology, it separated into premotor pre-diagnostic phases. incidence patients phase symptoms ranges from 0.07 14.30, the most frequently studied pathology is REM behavioral disorder (RBD). Neuroimaging are related dopamine denervation, brain perfusion changes, gross anatomy peripheral abnormalities. α-synuclein assays (SAA) CSF revealed high sensitivity (up 97%) specificity 92%); last decade, there was development other matrices (blood, skin, olfactory mucosa) for obtaining quantitative qualitative α-synuclein. Other biomarkers neurofilament light chain, DOPA decarboxylase, multiplexed mass spectrometry assay. Regarding genetic counseling α-synucleinopathies, an important topic clinical practice discuss high-risk individuals should involve basic principles autonomy, beneficence, non-maleficence. Some themes that reviewed involvement physical activity, diet (including alcohol, coffee, vitamin supplementation), smoking, sleep, stress pathophysiology number trials still scarce, studies evaluating intervention even lower.

Language: Английский

Association of 25-hydroxyvitamin D with Parkinson’s disease based on the results from the NHANES 2007 to 2018 and Mendelian randomization analysis DOI Creative Commons
Yan Xu, Jie Peng,

Zhou Xi-guo

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 14, 2025

An abundance of observational researches had suggested that vitamin D insufficient was related to Parkinson's disease (PD) risk. However, their relationships were debatable and the causality remains uncertain. We intended evaluate association between 25-hydroxyvitamin [25(OH)D] risk using NHANES data (2007–2018) Mendelian randomization (MR) analyses with genome-wide study (GWAS) summary data. Demographic characteristics multivariable-adjusted logistic regression conducted assess relationship serum 25(OH)D levels PD prevalence by utilizing database. Besides, a two-sample MR analysis applied causal The main citing inverse-variance-weighted (IVW) approach, while additional approaches multiple sensitivity cited robustness pleiotropy for discoveries. In total, 30,796 adults from 2007–2018 selected present research. As result, 1.1% participants (mean age: 61.9 ± 15.5 years), 68.5% reported insufficient. Compared without PD, those greater level (P < 0.01). after adjusted demographic comorbid factors, this not observed. Furthermore, no potential found via (IVW-MR: OR = 1.082; 95% CI, 0.902 1.297; P 0.395). After eliminating variants horizontal risk, pleiotropy-robust presented similar results. conclusion, research correlated Additionally, revealed significant at genetic level. Awareness these findings may improve personalized prevention treatment PD.

Language: Английский

Citations

0
A Narrative Review on Biochemical Markers and Emerging Treatments in Prodromal Synucleinopathies DOI Creative Commons
Jamir Pitton Rissardo, Ana Letícia Fornari Caprara

Clinics and Practice, Journal Year: 2025, Volume and Issue: 15(3), P. 65 - 65

Published: March 17, 2025

Alpha-synuclein has been associated with neurodegeneration, especially in Parkinson’s disease (PD). This study aimed to review clinical, biochemical, and neuroimaging markers management of prodromal synucleinopathies. The state synucleinopathies can be better understood PD pathophysiology, it separated into premotor pre-diagnostic phases. incidence patients phase symptoms ranges from 0.07 14.30, the most frequently studied pathology is REM behavioral disorder (RBD). Neuroimaging are related dopamine denervation, brain perfusion changes, gross anatomy peripheral abnormalities. α-synuclein assays (SAA) CSF revealed high sensitivity (up 97%) specificity 92%); last decade, there was development other matrices (blood, skin, olfactory mucosa) for obtaining quantitative qualitative α-synuclein. Other biomarkers neurofilament light chain, DOPA decarboxylase, multiplexed mass spectrometry assay. Regarding genetic counseling α-synucleinopathies, an important topic clinical practice discuss high-risk individuals should involve basic principles autonomy, beneficence, non-maleficence. Some themes that reviewed involvement physical activity, diet (including alcohol, coffee, vitamin supplementation), smoking, sleep, stress pathophysiology number trials still scarce, studies evaluating intervention even lower.

Language: Английский

Citations

0