The Multifaced Role of Collagen in Cancer Development and Progression DOI Open Access

Gabriele Lo Buglio,

Alessandra Lo Cicero, Simona Campora

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13523 - 13523

Published: Dec. 17, 2024

Collagen is a crucial protein in the extracellular matrix (ECM) essential for preserving tissue architecture and supporting cellular functions like proliferation differentiation. There are twenty-eight identified types of collagen, which further divided into different subgroups. This plays critical role regulating homeostasis. However, solid tumors, balance can be disrupted, due to an abundance collagen tumor microenvironment, significantly affects growth, cell invasion, metastasis. It important investigate specific collagens cancer ECM their distinct roles progression comprehend unique contribution behavior. The diverse pathophysiological cancers illustrate collagen’s dual roles, offering potential therapeutic options serving as prognostic markers.

Language: Английский

The Multifaced Role of Collagen in Cancer Development and Progression DOI Open Access

Gabriele Lo Buglio,

Alessandra Lo Cicero, Simona Campora

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13523 - 13523

Published: Dec. 17, 2024

Collagen is a crucial protein in the extracellular matrix (ECM) essential for preserving tissue architecture and supporting cellular functions like proliferation differentiation. There are twenty-eight identified types of collagen, which further divided into different subgroups. This plays critical role regulating homeostasis. However, solid tumors, balance can be disrupted, due to an abundance collagen tumor microenvironment, significantly affects growth, cell invasion, metastasis. It important investigate specific collagens cancer ECM their distinct roles progression comprehend unique contribution behavior. The diverse pathophysiological cancers illustrate collagen’s dual roles, offering potential therapeutic options serving as prognostic markers.

Language: Английский

Citations

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