From bench to bedside: targeting ferroptosis and mitochondrial damage in the treatment of diabetic cardiomyopathy DOI Creative Commons
Bin Liu, Qing Jin, Yi Sun

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: April 25, 2025

Diabetic cardiomyopathy (DCM) is a common and fatal cardiac complication caused by diabetes, with its pathogenesis involving various forms of cell death mitochondrial dysfunction, particularly ferroptosis injury. Recent studies have indicated that damage play crucial roles in the onset progression DCM, though their precise regulatory mechanisms remain unclear. Of particular interest interaction between damage, as well synergistic effects, which are not fully understood. This review summarizes injury DCM explores molecular involved, an emphasis on interplay these two processes. Additionally, article offers overview targeted drugs shown to be effective cellular experiments, animal models, clinical trials, analyzing action potential side effects. The goal provide insights for future drug development applications. Moreover, challenges prospects multi-target combination therapies personalized medicine interventions practice offer strategic guidance comprehensive prevention management DCM.

Language: Английский

Polygonum multiflorum Stilbene Glycoside Oligomers induce the ferroptosis of triple negative breast cancer cells DOI Creative Commons
Xiaomeng Lin, Hua Yang, Tingting Cai

et al.

BMC Cancer, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 14, 2025

The quality control testing component and main active ingredient of Polygonum multiflorum Thunb. (P. multiflorum), known as trans-2,3,5,4'-tetrahydroxystilbene 2-O-β-D-glucopyranoside (TSG), exhibits diverse biological activities. In this study, we report, for the first time, potent ability TSG to induce ferroptosis in triple negative breast cancer (TNBC) cell lines inhibit proliferation TNBC cells. Treatment with triggers production lipid peroxides, 4-hydroxynonenal (4-HNE), reactive oxygen species (ROS) cells, indicating induction ferroptosis. Both vivo vitro experiments confirmed inhibitory effects on metastasis. Furthermore, investigated other stilbene glycoside oligomers, alongside TSG, lines. These compounds also demonstrated suppress cells' findings suggest that by related could potentially serve a promising therapeutic strategy treatment.

Language: Английский

Citations

0
From bench to bedside: targeting ferroptosis and mitochondrial damage in the treatment of diabetic cardiomyopathy DOI Creative Commons
Bin Liu, Qing Jin, Yi Sun

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: April 25, 2025

Diabetic cardiomyopathy (DCM) is a common and fatal cardiac complication caused by diabetes, with its pathogenesis involving various forms of cell death mitochondrial dysfunction, particularly ferroptosis injury. Recent studies have indicated that damage play crucial roles in the onset progression DCM, though their precise regulatory mechanisms remain unclear. Of particular interest interaction between damage, as well synergistic effects, which are not fully understood. This review summarizes injury DCM explores molecular involved, an emphasis on interplay these two processes. Additionally, article offers overview targeted drugs shown to be effective cellular experiments, animal models, clinical trials, analyzing action potential side effects. The goal provide insights for future drug development applications. Moreover, challenges prospects multi-target combination therapies personalized medicine interventions practice offer strategic guidance comprehensive prevention management DCM.

Language: Английский

Citations

0