Recent developments in cuproptosis of glioblastoma DOI Creative Commons
Yanhui Chen, Jingxian Zhang, Hongwu Xu

et al.

Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: unknown, P. 155939 - 155939

Published: March 1, 2025

Glioblastoma (GBM) is the most malignant tumor within central nervous system, attributed to its high-grade malignancy, propensity for recurrence, refractoriness conventional therapeutic modalities, and suboptimal efficacy of current targeted therapies. Hence, there an urgent need identify more efficacious molecular targets intervention GBM. The regulated cell death (RCD) has specific signaling factors pathways. targeting RCD considered be one effective therapies At present, cuproptosis a novel form RCD, characterized by distinct mechanism that differentiates it from apoptosis, pyroptosis, necroptosis, ferroptosis. It principal mechanisms, which include copper dependency, accumulation acylated proteins, reduction Fe-S cluster-containing proteins. These processes collectively induce proteotoxic stress, culminating in death. In previous studies, copper-ionized formulations have demonstrated cytotoxic effects on gliomas. Thus, key may able serve as new target GBM treatment. This review delves into several pivotal aspects, including discovery cuproptosis, impact homeostasis tumorigenesis, role GBM, potential therapy this article could reveal strategies

Language: Английский

Recent developments in cuproptosis of glioblastoma DOI Creative Commons
Yanhui Chen, Jingxian Zhang, Hongwu Xu

et al.

Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: unknown, P. 155939 - 155939

Published: March 1, 2025

Glioblastoma (GBM) is the most malignant tumor within central nervous system, attributed to its high-grade malignancy, propensity for recurrence, refractoriness conventional therapeutic modalities, and suboptimal efficacy of current targeted therapies. Hence, there an urgent need identify more efficacious molecular targets intervention GBM. The regulated cell death (RCD) has specific signaling factors pathways. targeting RCD considered be one effective therapies At present, cuproptosis a novel form RCD, characterized by distinct mechanism that differentiates it from apoptosis, pyroptosis, necroptosis, ferroptosis. It principal mechanisms, which include copper dependency, accumulation acylated proteins, reduction Fe-S cluster-containing proteins. These processes collectively induce proteotoxic stress, culminating in death. In previous studies, copper-ionized formulations have demonstrated cytotoxic effects on gliomas. Thus, key may able serve as new target GBM treatment. This review delves into several pivotal aspects, including discovery cuproptosis, impact homeostasis tumorigenesis, role GBM, potential therapy this article could reveal strategies

Language: Английский

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