The role of NK cells in fighting the virus infection and sepsis DOI Creative Commons
Lu Ma, Qi Li,

Suna Cai

et al.

International Journal of Medical Sciences, Journal Year: 2021, Volume and Issue: 18(14), P. 3236 - 3248

Published: Jan. 1, 2021

Natural killer cells, one of the important types innate immune play a pivotal role in antiviral process vivo.It has been shown that increasing NK cell activity may promote alleviation viral infections, even severe infection-induced sepsis.Given current state novel coronavirus (SARS-CoV-2) global pandemic, clarifying anti-viral function cells would be helpful for revealing mechanism host responses and decipher progression COVID-19 providing clues combating this pandemic.In review, we summarize roles infection sepsis as well potential possibilities cell-based immunotherapy treating COVID-19.

Language: Английский

Allogeneic immunity clears latent virus following allogeneic stem cell transplantation in SIV-infected ART-suppressed macaques DOI Creative Commons
Helen L. Wu, Kathleen Busman‐Sahay, Whitney C. Weber

et al.

Immunity, Journal Year: 2023, Volume and Issue: 56(7), P. 1649 - 1663.e5

Published: May 25, 2023

Language: Английский

Citations

19
The initial interplay between HIV and mucosal innate immunity DOI Creative Commons

Valeria Caputo,

Martina Libera,

Sofia Sisti

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Jan. 30, 2023

Human Immunodeficiency Virus (HIV) is still one of the major global health issues, and despite significant efforts that have been put into studying pathogenesis HIV infection, several aspects need to be clarified, including how innate immunity acts in different anatomical compartments. Given nature as a sexually transmitted disease, demands particular attention mucosal immune response. this scenario, we focused our on interplay between response: mucosae act physical barrier, whose integrity can compromised by virus-cell interaction induces In addition, explored role microbiota facilitating or preventing infection highlighted its changes could influence development opportunistic infections. Although recent progress, proper characterization response missing, further studies are needed understand they helpful for formulation an effective vaccine.

Language: Английский

Citations

18
Robust expansion of HIV CAR T cells following antigen boosting in ART-suppressed nonhuman primates DOI Open Access
Blake J. Rust, Leslie S. Kean, Lucrezia Colonna

et al.

Blood, Journal Year: 2020, Volume and Issue: 136(15), P. 1722 - 1734

Published: July 2, 2020

Language: Английский

Citations

45
Engineering CAR T Cells to Target the HIV Reservoir DOI Creative Commons
Wenli Mu, Mayra A. Carrillo, Scott G. Kitchen

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2020, Volume and Issue: 10

Published: Aug. 13, 2020

The HIV reservoir remains to be a difficult barrier overcome in order achieve therapeutic cure for HIV. Several strategies have been developed purge the reservoir, including "kick and kill" approach, which is based on notion that reactivating latent will allow subsequent elimination by host anti-HIV immune cells. However, clinical trials testing certain classes of latency agents (LRAs) so far revealed minimal impact reducing viral reservoir. A robust response reactivated expressing cells critical this strategy work. current focus enhance immunity through use chimeric antigen receptors (CARs). Currently, HIV-specific CARs are being applied peripheral T cells, NK stem boost recognition killing infected In review, we summarize developments engineering directed CAR-expressing facilitate elimination. We also LRAs "kick" how new generation combinations with specific CAR cell therapies could provide an optimal target clearance from body.

Language: Английский

Citations

40
The role of NK cells in fighting the virus infection and sepsis DOI Creative Commons
Lu Ma, Qi Li,

Suna Cai

et al.

International Journal of Medical Sciences, Journal Year: 2021, Volume and Issue: 18(14), P. 3236 - 3248

Published: Jan. 1, 2021

Natural killer cells, one of the important types innate immune play a pivotal role in antiviral process vivo.It has been shown that increasing NK cell activity may promote alleviation viral infections, even severe infection-induced sepsis.Given current state novel coronavirus (SARS-CoV-2) global pandemic, clarifying anti-viral function cells would be helpful for revealing mechanism host responses and decipher progression COVID-19 providing clues combating this pandemic.In review, we summarize roles infection sepsis as well potential possibilities cell-based immunotherapy treating COVID-19.

Language: Английский

Citations

35