Genomic data reveal a north-south split and introgression history of blood fluke (Schistosoma haematobium) populations from across Africa DOI Creative Commons
Roy N. Platt, Egie E. Enabulele,

Ehizogie Adeyemi

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 8, 2024

Abstract The human parasitic fluke, Schistosoma haematobium hybridizes with the livestock parasite S. bovis in laboratory, but extent of hybridization nature is unclear. We analyzed 34.6 million single nucleotide variants 162 samples from 18 African countries, revealing a sharp genetic discontinuity between northern and southern . found no evidence for recent hybridization. Instead data reveal admixture events that occurred 257-879 generations ago populations. Fifteen introgressed genes are approaching fixation four potentially driving adaptation. identified 19 regions were resistant to introgression; these enriched on sex chromosomes. These results (i) demonstrate strong barriers gene flow species, (ii) indicate may be less common than currently envisaged, (iii) profound genomic consequences interspecific schistosomes medical veterinary importance.

Language: Английский

Vitamin K2 - Vital for Health and Wellbeing DOI
Adriana V. Díaz, Martin Walker, Joanne P. Webster

et al.

InTech eBooks, Journal Year: 2017, Volume and Issue: unknown

Published: March 22, 2017

This book serves as a comprehensive survey of the impact vitamin K2 on cellular functions and organ systems, indicating that plays an important role in differentiation/preservation various cell phenotypes stimulator and/or mediator interorgan cross talk. Vitamin binds to transcription factor SXR/PXR, thus acting like hormone (very much same manner A D). Therefore, affects multitude it is reckoned be one positive bringing about "longevity" human body, e.g., supporting functions/health different well correcting functioning or even "curing" ailments striking several organs our body.
Kappa - Vital for Health Wellbeing has been produced distributed through support from Kappa Bioscience, Norway.

Language: Английский

Citations

32
Bulinus snails in the Lake Victoria Basin in Kenya: Systematics and their role as hosts for schistosomes DOI Creative Commons
Caitlin Babbitt, Martina R. Laidemitt,

Martin W. Mutuku

et al.

PLoS neglected tropical diseases, Journal Year: 2023, Volume and Issue: 17(2), P. e0010752 - e0010752

Published: Feb. 10, 2023

The planorbid gastropod genus Bulinus consists of 38 species that vary in their ability to vector Schistosoma haematobium (the causative agent human urogenital schistosomiasis), other species, and non-schistosome trematodes. Relying on sequence-based identifications bulinids (partial cox1 16S ) ( ITS ), we examined the Lake Victoria Basin Kenya for naturally acquired infections with species. We collected 6,133 from 11 sites between 2014–2021, 226 (3.7%) which harbored infections. found 4 taxa B . truncatus , tropicus ugandae cf transversalis an additional habitats globosus productus forskalii scalaris ). S were (with former predominating) whereas bovis identified No nuclear/mitochondrial discordance potentially indicative haematobium/S hybridization was detected. highlight presence as a distinct lake-dwelling taxon closely related yet, unlike all members africanus group, is likely not though it does exhibit susceptibility Other also lacked infections, supporting possibility they lack compatibility local thereby preventing widespread transmission schistosomiasis lake’s waters. support nasutus add further evidence complex three lineages represented alone. This study serves essential prelude investigating why these patterns exist whether underlying biological mechanisms may be exploited purpose limiting schistosome transmission.

Language: Английский

Citations

9
Natural Intra- and Interclade Human Hybrid Schistosomes in Africa with Considerations on Prevention through Vaccination DOI Creative Commons

Ursula Panzner,

Jérôme Boissier

Microorganisms, Journal Year: 2021, Volume and Issue: 9(7), P. 1465 - 1465

Published: July 8, 2021

Causal agents of schistosomiasis are dioecious, digenean schistosomes affecting mankind in 76 countries. Preventive measures manifold but need to be complemented by vaccination for long-term protection; vaccine candidates advanced pre-clinical/clinical stages include Sm14, Sm-TSP-2/Sm-TSP-2Al®, Smp80/SchistoShield®, and Sh28GST/Bilhvax®. Natural anthropogenic changes impact on breaking species isolation barriers favoring introgressive hybridization, i.e., allelic exchange among gene pools sympatric, interbreeding leading instant large genetic diversity. Phylogenetic distance matters, thus the less differ phylogenetically more likely they hybridize. PubMed Embase databases were searched publications limited hybridale confirmation mitochondrial cytochrome c oxidase (COX) and/or nuclear ribosomal internal transcribed spacer (ITS). Human schistosomal hybrids predominantly reported from West Africa with clustering Senegal River Basin, scattering Europe, Central Eastern Africa. Noteworthy is dominance Schistosoma haematobium human veterinary due hybrid vigor extinction homogenization as seen S. guineensis Cameroon Niger, respectively. Heterosis seems advantage haematobium/S. bovis interbreeds dominant haematobium-ITS/S. bovis-COX1 profile spread East reoccur France. mansoni interactions Senegalese Côte d’Ivoirian children unexpected their high phylogenetic distance. Detecting pure bovis/S. curassoni crosses capable infecting humans observed Corsica d’Ivoire, respectively, worrisome. Taken together, hybridization urges control preventive targeting sectors line One-Health concept protecting against transmission, infection, disease recurrence. Functional structural diversity naturally occurring may current requiring further research including natural history studies endemic areas targeted clinical trials.

Language: Английский

Citations

20
Vertebral Plasma Cell Tumors in 8 Dogs DOI
Clare Rusbridge, Simon J. Wheeler, Christopher R. Lamb

et al.

Journal of Veterinary Internal Medicine, Journal Year: 1999, Volume and Issue: 13(2), P. 126 - 126

Published: Jan. 1, 1999

The case histories of 8 dogs with spinal pain and neurologic deficits associated vertebral plasma cell tumor are reviewed. Four had solitary plasmacytoma, 3 multiple myeloma, 1 dog 2 lesions no evidence disseminated disease. were treated: myeloma received chemotherapy only survived 17 26 months, respectively. Two plasmacytomas the spine radiotherapy: 1st 4 months was euthanized after developing radiation myelopathy; 2nd 65 before myeloma. diagnosis plasmacytoma versus is discussed.

Language: Английский

Citations

46
Genomic data reveal a north-south split and introgression history of blood fluke (Schistosoma haematobium) populations from across Africa DOI Creative Commons
Roy N. Platt, Egie E. Enabulele,

Ehizogie Adeyemi

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 8, 2024

Abstract The human parasitic fluke, Schistosoma haematobium hybridizes with the livestock parasite S. bovis in laboratory, but extent of hybridization nature is unclear. We analyzed 34.6 million single nucleotide variants 162 samples from 18 African countries, revealing a sharp genetic discontinuity between northern and southern . found no evidence for recent hybridization. Instead data reveal admixture events that occurred 257-879 generations ago populations. Fifteen introgressed genes are approaching fixation four potentially driving adaptation. identified 19 regions were resistant to introgression; these enriched on sex chromosomes. These results (i) demonstrate strong barriers gene flow species, (ii) indicate may be less common than currently envisaged, (iii) profound genomic consequences interspecific schistosomes medical veterinary importance.

Language: Английский

Citations

2