Multidrug-resistant hypervirulent Klebsiella pneumoniae : an evolving superbug DOI
Yuzhong Zheng,

Xiaojue Zhu,

Chao Ding

et al.

Future Microbiology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13

Published: March 26, 2025

Multidrug-resistant hypervirulent Klebsiella pneumoniae (MDR-hvKP) combines high pathogenicity with multidrug resistance to become a new superbug. MDR-hvKP reports continue emerge, shattering the perception that K. (hvKP) strains are antibiotic sensitive. Patients infected have been reported in Asia, particularly China. Although hvKP can acquire drug genes, seems be more easily transformed from classical (cKP), which has strong gene uptake ability. To better understand biology of MDR-hvKP, this review discusses virulence factors, mechanisms, formation pathways, and identification MDR-hvKP. Given their destructive transmissible potential, continued surveillance these organisms enhanced control measures should prioritized.

Language: Английский

The State-of-the-Art Antibacterial Activities of Glycyrrhizin: A Comprehensive Review DOI Creative Commons

Ru-Yi Chen,

Jinjin Shi, Yanjun Liu

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(6), P. 1155 - 1155

Published: June 6, 2024

Licorice (Glycyrrhiza glabra) is a plant of the genus Glycyrrhiza in family Fabaceae/Leguminosae and renowned natural herb with long history medicinal use dating back to ancient times. Glycyrrhizin (GLY), main active component licorice, serves as widely utilized therapeutic agent clinical practice. GLY exhibits diverse properties, including anti-inflammatory, antibacterial, antiviral, antitumor, immunomodulatory, intestinal environment maintenance, liver protection effects. However, current research primarily emphasizes GLY’s antiviral activity, while providing limited insight into its antibacterial properties. demonstrates broad spectrum activity via inhibiting growth bacteria by targeting bacterial enzymes, impacting cell membrane formation, altering permeability. Moreover, can also bolster host immunity activating pertinent immune pathways, thereby enhancing pathogen clearance. This paper reviews inhibitory mechanisms against various pathogenic bacteria-induced pathological changes, role high-mobility group box 1 inhibitor regulation, efficacy combating diseases caused bacteria. Furthermore, combining other antibiotics reduces minimum concentration, potentially aiding development combination therapies drug-resistant Sources information were searched using PubMed, Web Science, Science Direct, GreenMedical for keywords “licorice”, “Glycyrrhizin”, “antibacterial”, “anti-inflammatory”, “HMGB1”, combinations thereof, mainly from articles published 1979 2024, no language restrictions. Screening was carried out one author supplemented others. Papers experimental flaws their design papers that did not meet expectations (antifungal papers, etc.) excluded.

Language: Английский

Citations

9
Klebsiella pneumoniae emerging anti-immunology paradigms: from stealth to evasion DOI Creative Commons
Joana Sá‐Pessoa, Ricardo Calderón-González,

Alix Lee

et al.

Trends in Microbiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Klebsiella pneumoniae (KP) is a global threat to human health due the isolation of multidrug-resistant strains. Despite advancements in understanding KP's population structure, antibiotic resistance mechanisms, and transmission patterns, gap remains how KP evades defenses, allowing pathogen flourish tissues despite an activated immune system. infection biology has been shaped by notion that evolved shield from defenses more than actively suppress them. This review describes new paradigms exploits coevolution with innate system hijack effectors receptors ablate signaling pathways counteract cell-intrinsic immunity, making apparent can no longer be considered only as stealth pathogen.

Language: Английский

Citations

0
Klebsiella pneumoniae disrupts vasodilation by targeting eNOS post translational modifications via the type VI secretion system and the capsule polysaccharide DOI Creative Commons
Safi Rehman, Joana Sá‐Pessoa, Charlotte Buckley

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

SUMMARY Vasodilation is a crucial protective response to inflammation and infection. Endothelial cells control vasodilation through the bioavailability of eNOS-produced nitric oxide (NO), generation endothelium-dependent hyperpolarization (EDH). Here, we demonstrate that Klebsiella pneumoniae , one most prevalent blood stream infection pathogens, inhibits agonist-induced by blunting NO-dependent pathway attenuating EDH pathway. The type VI secretion system (T6SS) effector VgrG4 licences kinase PKCβ in an NLRX1-controlled mitochondria reactive oxygen species (mtROS)-dependent manner phosphorylate eNOS inhibitory site Thr 495 effectively dampening activity. capsule polysaccharide, on other hand, limits phosphorylation activation Ser 1177 inducing phosphatase PP2Ac upon EGF receptor-dependent VgrG4-induced mtROS attenuates Overall, this work reveals new anti-host activity T6SS illustrates how pathogens can vascular biology targeting post translational modifications.

Language: Английский

Citations

0
Insights into the roles of macrophages in Klebsiella pneumoniae infections: a comprehensive review DOI Creative Commons
Yangguang Li,

Xuanheng Li,

Wenqi Wu

et al.

Cellular & Molecular Biology Letters, Journal Year: 2025, Volume and Issue: 30(1)

Published: March 26, 2025

Abstract Klebsiella pneumoniae (KP) infections represent a significant global health challenge, characterized by severe inflammatory sequelae and escalating antimicrobial resistance. This comprehensive review elucidates the complex interplay between macrophages KP, encompassing pathogen recognition mechanisms, macrophage activation states, cellular death pathways, emerging immunotherapeutic strategies. We critically analyze current literature on pattern receptor engagement with KP-associated molecular patterns. The examines spectrum of responses to KP infection, including classical M1 polarization newly described M(Kp) phenotype, alongside metabolic reprogramming events such as glycolytic enhancement immune responsive gene 1 (IRG1)–itaconate upregulation. systematically evaluate fate decisions in response autophagy, apoptosis, pyroptosis, necroptosis. Furthermore, we provide critical assessment potential future therapeutic modalities. Given limitations treatment paradigms, elucidating macrophage–KP interactions is imperative. Insights gained from this analysis may inform development novel immunomodulatory approaches augment conventional therapies, potentially transforming clinical management infections. Graphical

Language: Английский

Citations

0
Multidrug-resistant hypervirulent Klebsiella pneumoniae : an evolving superbug DOI
Yuzhong Zheng,

Xiaojue Zhu,

Chao Ding

et al.

Future Microbiology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13

Published: March 26, 2025

Multidrug-resistant hypervirulent Klebsiella pneumoniae (MDR-hvKP) combines high pathogenicity with multidrug resistance to become a new superbug. MDR-hvKP reports continue emerge, shattering the perception that K. (hvKP) strains are antibiotic sensitive. Patients infected have been reported in Asia, particularly China. Although hvKP can acquire drug genes, seems be more easily transformed from classical (cKP), which has strong gene uptake ability. To better understand biology of MDR-hvKP, this review discusses virulence factors, mechanisms, formation pathways, and identification MDR-hvKP. Given their destructive transmissible potential, continued surveillance these organisms enhanced control measures should prioritized.

Language: Английский

Citations

0