Eastern Equine Encephalitis Virus: The Importance of Metabolism and Aging DOI Open Access
Paweł Kordowitzki

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13318 - 13318

Published: Dec. 12, 2024

Eastern equine encephalitis virus (EEEV) is a mosquito-transmitted alphavirus that, among humans, can cause severe and often fatal illness. The zoonotic EEEV enzootic cycle involves of transmission between Culiseta melanura avian hosts, frequently resulting in spillover to dead-end vertebrate hosts such as humans horses. Interestingly, it has been described that the W132G mutation very low-density lipoprotein receptor (VLDLR), EEEV, significantly enhanced VLDLR-mediated cell attachment EEEV. patient’s metabolism plays pivotal role shaping complex landscape viral zoonosis. represents significant public health concern due its clinical outcomes, challenging epidemiological characteristics, certain risk factors heighten susceptibility specific populations or age groups. Age one several predictors impact outcome infection; juvenile animals appear be particularly vulnerable disease. This also observed natural infections, children are most severely impacted humans. aim this piece shed light on intricate relationship human virus.

Language: Английский

The Essential Role of Mitochondrial Dynamics in Viral Infections DOI Open Access
Xujie Duan, Rui Liu, Wenjun Lan

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 1955 - 1955

Published: Feb. 24, 2025

Mitochondria are dynamic organelles that play crucial roles in energy production, metabolic balance, calcium homeostasis, apoptosis, and innate immunity, key determinants of cell fate. They also targets for viral invasion the body. Many proteins target mitochondria, controlling mitochondrial morphology, metabolism, immune response, thereby achieving evasion, promoting their proliferation, accelerating infection process. Mitochondrial quality control is to maintaining normal physiological functions homeostasis. Dysregulation dynamics closely related development many diseases. New constantly being discovered. Viruses change by targeting mitochondria achieve a persistent state infection. Currently, understanding during limited. Research on impact provides foundation investigating pathogenesis infections, disease process, identifying potential therapeutic targets. This review focuses connection between priority areas research virus-mediated insight into regulation viruses explores means mitochondrial-mediated treatment

Language: Английский

Citations

0
Mitochondrial DNA signals driving immune responses: Why, How, Where? DOI Creative Commons
Luca Giordano, Sarah A. Ware, Claúdia Jacques Lagranha

et al.

Cell Communication and Signaling, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 22, 2025

Abstract There has been a recent expansion in our understanding of DNA-sensing mechanisms. Mitochondrial dysfunction, oxidative and proteostatic stresses, instability impaired disposal nucleoids cause the release mitochondrial DNA (mtDNA) from mitochondria several human diseases, as well cell culture animal models. mislocalized to cytosol and/or extracellular compartments can trigger innate immune inflammation responses by binding receptors (DSRs). Here, we define features that make mtDNA highly immunogenic mechanisms its into compartments. We describe major DSRs bind such cyclic guanosine-monophosphate-adenosine-monophosphate synthase (cGAS), Z-DNA-binding protein 1 (ZBP1), NOD-, LRR-, PYD- domain-containing 3 receptor (NLRP3), absent melanoma 2 (AIM2) toll-like 9 (TLR9), their downstream signaling cascades. summarize key findings, novelties, gaps driving signal vascular, metabolic, kidney, lung, neurodegenerative viral bacterial infections. Finally, common strategies induce or inhibit propose challenges advance field.

Language: Английский

Citations

0
Correction: RVFV virulence factor NSs triggers the mitochondrial MCL-1-BAK axis to activate pathogenic NLRP3 pyroptosis DOI Creative Commons

Zhenqiong Guan,

Huiling Li,

Chongtao Zhang

et al.

PLoS Pathogens, Journal Year: 2025, Volume and Issue: 21(4), P. e1013113 - e1013113

Published: April 24, 2025

[This corrects the article DOI: 10.1371/journal.ppat.1012387.].

Language: Английский

Citations

0
Eastern Equine Encephalitis Virus: The Importance of Metabolism and Aging DOI Open Access
Paweł Kordowitzki

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13318 - 13318

Published: Dec. 12, 2024

Eastern equine encephalitis virus (EEEV) is a mosquito-transmitted alphavirus that, among humans, can cause severe and often fatal illness. The zoonotic EEEV enzootic cycle involves of transmission between Culiseta melanura avian hosts, frequently resulting in spillover to dead-end vertebrate hosts such as humans horses. Interestingly, it has been described that the W132G mutation very low-density lipoprotein receptor (VLDLR), EEEV, significantly enhanced VLDLR-mediated cell attachment EEEV. patient’s metabolism plays pivotal role shaping complex landscape viral zoonosis. represents significant public health concern due its clinical outcomes, challenging epidemiological characteristics, certain risk factors heighten susceptibility specific populations or age groups. Age one several predictors impact outcome infection; juvenile animals appear be particularly vulnerable disease. This also observed natural infections, children are most severely impacted humans. aim this piece shed light on intricate relationship human virus.

Language: Английский

Citations

0