Age, Sex, Body Mass Index, Diet and Menopause Related Metabolites in a Large Homogeneous Alpine Cohort DOI Creative Commons
Vinicius Verri Hernandes, Nikola Đorđević, Essi Hantikainen

et al.

Metabolites, Journal Year: 2022, Volume and Issue: 12(3), P. 205 - 205

Published: Feb. 24, 2022

Metabolomics in human serum samples provide a snapshot of the current metabolic state an individuum. Metabolite concentrations are influenced by both genetic and environmental factors. Concentrations certain metabolites can further depend on age, sex, menopause, diet study participants. A better understanding these relationships is pivotal for planning metabolomics studies involving subjects interpretation their results. We generated one largest single-site targeted data sets consisting 175 quantified 6872 identified significantly associated with body mass index, diet, menopausal status. While most our results agree previous large-scale studies, we also found novel associations including serotonin as sex BMI-related metabolite sarcosine C2 carnitine showing higher post-menopausal women. Finally, observed strong between consumption food items metabolites, mostly phosphatidylcholines lysophosphatidylcholines. Most, strongest, were habitual meat intake while no significant fruits, vegetables, grain products. Summarizing, reconfirm findings from population-based independent cohort. Together, will ultimately enable consolidation which related to BMI, menopause well participants' diet.

Language: Английский

Dietary patterns and cancer risk DOI
Susan E. Steck, E. Angela Murphy

Nature reviews. Cancer, Journal Year: 2019, Volume and Issue: 20(2), P. 125 - 138

Published: Dec. 17, 2019

Language: Английский

Citations

237
The Mediterranean diet, plasma metabolome, and cardiovascular disease risk DOI Open Access
Jun Li, Marta Guasch‐Ferré, Wonil Chung

et al.

European Heart Journal, Journal Year: 2020, Volume and Issue: 41(28), P. 2645 - 2656

Published: March 18, 2020

Abstract Aims To investigate whether metabolic signature composed of multiple plasma metabolites can be used to characterize adherence and response the Mediterranean diet such a is associated with cardiovascular disease (CVD) risk. Methods results Our primary study cohort included 1859 participants from Spanish PREDIMED trial, validation cohorts 6868 US Nurses’ Health Studies I II, Professionals Follow-up Study (NHS/HPFS). Adherence was assessed using validated Diet Screener (MEDAS), metabolome profiled by liquid chromatography-tandem mass spectrometry. We observed substantial metabolomic variation respect adherence, nearly one-third assayed significantly MEDAS (false discovery rate < 0.05). Using elastic net regularized regressions, we identified signature, comprised 67 metabolites, robustly correlated in both NHS/HPFS (r = 0.28–0.37 between MEDAS; P 3 × 10−35 4 10−118). In multivariable Cox showed significant inverse association CVD incidence after adjusting for known risk factors (PREDIMED: hazard ratio [HR] per standard deviation increment 0.71, 0.001; NHS/HPFS: HR 0.85, 0.001), persisted further adjustment scores 0.73, 0.004; 0.004). Further genome-wide analysis revealed that genetic loci involved fatty acids amino metabolism. Mendelian randomization analyses genetically inferred coronary heart (CHD) stroke (odds ratios SD 0.92 CHD 0.91 stroke; 0.001). Conclusions reflects diet, predicts future independent traditional factors, cohorts.

Language: Английский

Citations

232
Benefits of the Mediterranean diet: Epidemiological and molecular aspects DOI
Lluís Serra‐Majem, Blanca Román-Viñas, Almudena Sánchez‐Villegas

et al.

Molecular Aspects of Medicine, Journal Year: 2019, Volume and Issue: 67, P. 1 - 55

Published: June 1, 2019

Language: Английский

Citations

188
Mass spectrometry-based metabolomics in health and medical science: a systematic review DOI Creative Commons
Xiwu Zhang,

Qiu-Han Li,

Zuo-di Xu

et al.

RSC Advances, Journal Year: 2020, Volume and Issue: 10(6), P. 3092 - 3104

Published: Jan. 1, 2020

Metabolomics is the study of investigation small molecules derived from cellular and organism metabolism, which reflects outcomes complex network biochemical reactions in living systems.

Language: Английский

Citations

154
Benefits of pulse consumption on metabolism and health: A systematic review of randomized controlled trials DOI Creative Commons
Helena Ferreira, Marta W. Vasconcelos, Ana M. Gil

et al.

Critical Reviews in Food Science and Nutrition, Journal Year: 2020, Volume and Issue: 61(1), P. 85 - 96

Published: Jan. 25, 2020

Pulses are nutrient-dense foods that have for a long time been empirically known to beneficial effects in human health. In the last decade, several studies gathered evidence of metabolic benefits pulse intake. However, it remains unclear at what amounts these may be attained. This study aimed systematically review scientific outputs two decades regarding health consumption and necessary positive outcomes achieved. A PubMed search including keywords [("dietary pulses", "pulses", "legumes", "grain legumes", "bean", "chickpea", "pea", "lentil", "cowpea", "faba bean", "lupin") ("inflammation", "inflammatory markers", "C-reactive protein", "blood lipids", "cholesterol", "cardiometabolic health", "cardiovascular disease", "diabetes", "glycaemia", "insulin", "HOMA-IR", "body weight", fat", "obesity", "overweight", "metabolome", "metabolic profile", "metabolomics", "biomarkers", "microbiome", "microbiota", "gut")] was performed. Only English written papers referring dietary interventions, longer than one day, focusing on whole pulses intake, were included. Most twenty eligible publications reported improvements blood lipid profile, pressure, inflammation biomarkers, as well as, body composition, resulting from daily 150 g (minimum-maximum: 54-360 g/day; cooked). Concerns methodological approaches evident biochemical mechanisms underlying such require further investigation.

Language: Английский

Citations

137
Diet and liver cancer risk: a narrative review of epidemiological evidence DOI
Wanshui Yang, Xufen Zeng, Zhining Liu

et al.

British Journal Of Nutrition, Journal Year: 2020, Volume and Issue: 124(3), P. 330 - 340

Published: April 1, 2020

Primary liver cancer is the third leading cause of cancer-related death worldwide. Most patients are diagnosed at late stages with poor prognosis; thus, identification modifiable risk factors for primary prevention urgently needed. The well-established include chronic infection hepatitis B virus (HBV) or C (HCV), heavy alcohol consumption, metabolic diseases such as obesity and diabetes, aflatoxin exposure. However, a large proportion cases worldwide cannot be explained by current known factors. Dietary have been suspected important, but dietary aetiology remains poorly understood. In this review, we summarised evaluated observational studies diet including single nutrients, food groups, well patterns developing cancer. Although there knowledge gaps between risk, epidemiological evidence supports an important role in development. For example, exposure to aflatoxin, drinking possibly dairy product (not yogurt) intake increase, while coffee, fish tea, light-to-moderate several healthy (e.g. Alternative Healthy Eating Index) may decrease risk. Future sample size accurate measurement warranted need consider issues possible aetiological heterogeneity subtypes, influence HBV HCV infection, high-risk populations cirrhosis) potential interplay host gut microbiota genetic variations.

Language: Английский

Citations

132
Perspective: Dietary Biomarkers of Intake and Exposure—Exploration with Omics Approaches DOI Creative Commons
Padma Maruvada, Johanna W. Lampe, David S. Wishart

et al.

Advances in Nutrition, Journal Year: 2019, Volume and Issue: 11(2), P. 200 - 215

Published: June 20, 2019

Language: Английский

Citations

109
Chromatography hyphenated to high resolution mass spectrometry in untargeted metabolomics for investigation of food (bio)markers DOI
Leticia Lacalle-Bergeron, David Izquierdo-Sandoval, Juan V. Sancho

et al.

TrAC Trends in Analytical Chemistry, Journal Year: 2020, Volume and Issue: 135, P. 116161 - 116161

Published: Dec. 24, 2020

Language: Английский

Citations

88
Metabolomics and Microbiomes as Potential Tools to Evaluate the Effects of the Mediterranean Diet DOI Open Access
Qi Jin,

Alicen Black,

Stefanos N. Kales

et al.

Nutrients, Journal Year: 2019, Volume and Issue: 11(1), P. 207 - 207

Published: Jan. 21, 2019

The approach to studying diet–health relationships has progressively shifted from individual dietary components overall patterns that affect the interaction and balance of low-molecular-weight metabolites (metabolome) host-enteric microbial ecology (microbiome). Even though Mediterranean diet (MedDiet) been recognized as a powerful strategy improve health, accurate assessment exposure MedDiet major challenge in epidemiological clinical studies. Interestingly, while effects on metabolome have described, studies investigating metabolomic profiles response (including MedDiet), although limited, gaining attention. Similarly, beneficial cardiometabolic outcomes may be mediated through gut changes. Accumulating evidence linking food ingestion enteric microbiome alterations merits evaluation microbiome-mediated metabolic pathways implicated disease. In this narrative review, we aimed summarize current observational trials involving by (1) assessing changes for measurement pattern adherence (2) health related human metabolomics and/or microbiome.

Language: Английский

Citations

79
Precision (Personalized) Nutrition: Understanding Metabolic Heterogeneity DOI Open Access
Steven H. Zeisel

Annual Review of Food Science and Technology, Journal Year: 2020, Volume and Issue: 11(1), P. 71 - 92

Published: Jan. 13, 2020

People differ in their requirements for and responses to nutrients bioactive molecules the diet. Many inputs contribute metabolic heterogeneity (including variations genetics, epigenetics, microbiome, lifestyle, diet intake, environmental exposure). Precision nutrition is not about developing unique prescriptions individual people but rather stratifying into different subgroups of population on basis biomarkers above-listed sources variation then using this stratification better estimate subgroups’ dietary requirements, thereby enabling recommendations interventions. The hope that we will be able subcategorize ever-smaller groups can targeted terms recommendations, never achieve at level, thus, choice precision than personalized designate new field. This review focuses mainly genetically related identifies challenges need overcome a full understanding complex interactions between many make from one another foods. It also discusses commercial applications nutrition.

Language: Английский

Citations

79