Arabidopsis Transcriptome Analysis Reveals Key Roles of Melatonin in Plant Defense Systems

PLoS ONE, Journal Year: 2014, Volume and Issue: 9(3), P. e93462 - e93462

Published: March 28, 2014

Melatonin is a ubiquitous molecule and exists across kingdoms including plant species. Studies on melatonin in plants have mainly focused its physiological influence growth development, biosynthesis. Much less attention has been drawn to affect genome-wide gene expression. To comprehensively investigate the role(s) of at genomics level, we utilized mRNA-seq technology analyze Arabidopsis subjected 16-hour 100 pM (low) 1 mM (high) treatment. The expression profiles were analyzed identify differentially expressed genes. treatment significantly affected only 81 genes with 51 down-regulated 30 up-regulated. However, altered 1308 566 up-regulated 742 down-regulated. Not all by low high melatonin, indicating different roles regulation development under concentrations. Furthermore, large number involved stress defense. Transcript levels for many receptors, kinases, stress-associated calcium signals majority transcription factors identified also Additionally, most ABA, ET, SA JA pathways up-regulated, while pertaining auxin responses signaling, peroxidases, those associated cell wall synthesis modifications mostly Our results indicate critical defense against various environmental stresses, provide framework functional analysis melatonin-mediated signaling pathways.

Language: Английский

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The changing biological roles of melatonin during evolution: from an antioxidant to signals of darkness, sexual selection and fitness

Biological reviews/Biological reviews of the Cambridge Philosophical Society, Journal Year: 2009, Volume and Issue: 85(3), P. 607 - 623

Published: Dec. 21, 2009

Melatonin is a molecule present in multitude of taxa and may be ubiquitous organisms. It has been found bacteria, unicellular eukaryotes, macroalgae, fungi, plants animals. A primary biological function melatonin primitive organisms antioxidant defence to protect against toxic free radical damage. During evolution, adopted by multicellular perform many other functions. These functions likely include the chemical expression darkness vertebrates, environmental tolerance fungi plants, sexual signaling birds fish, seasonal reproductive regulation photoperiodic mammals, immunomodulation anti-inflammatory activity all vertebrates tested. Moreover, its waning production during aging indicate senescence terms bio-clock Conversely, high levels can serve as signal vitality health. The multiple partially attributed unconventional metabolism which comprised multi-enzymatic, pseudo-enzymatic non-enzymatic pathways. As result, several bioactive metabolites are formed some presumed reported date may, fact, mediated these metabolites. changing roles seem have evolved from an antioxidant.

Language: Английский

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Cardiovascular diseases: protective effects of melatonin

Journal of Pineal Research, Journal Year: 2007, Volume and Issue: 44(1), P. 16 - 25

Published: Oct. 31, 2007

Abstract: This brief review considers some of the cardiac diseases and conditions where free radicals related reactants are believed to be causative. The report also describes beneficial actions melatonin against oxidative cardiovascular disorders. Based on data available, seems have cardioprotective properties via its direct radical scavenger indirect antioxidant activity. Melatonin efficiently interacts with various reactive oxygen nitrogen species (receptor independent actions) it upregulates enzymes downregulates pro‐oxidant (receptor‐dependent actions). Moreover, enters all cells subcellular compartments crosses morphophysiologic barriers. These findings implications for protective effects induced by stress. attenuates molecular cellular damages resulting from ischemia/reperfusion in which destructive involved. Anti‐inflammatory antioxidative involved protection a chronic vascular disease, atherosclerosis. administration melatonin, as result features, has been reported reduce hypertension cardiotoxicity clinically used drugs. results described herein help clarify these define potential clinical applicability diseases.

Language: Английский

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Melatonin: A pleiotropic molecule regulating inflammation

Biochemical Pharmacology, Journal Year: 2010, Volume and Issue: 80(12), P. 1844 - 1852

Published: Aug. 8, 2010

Language: Английский

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Phytomelatonin: Assisting Plants to Survive and Thrive

Molecules, Journal Year: 2015, Volume and Issue: 20(4), P. 7396 - 7437

Published: April 22, 2015

This review summarizes the advances that have been made in terms of identified functions melatonin plants. Melatonin is an endogenously-produced molecule all plant species investigated. Its concentration organs varies different tissues, e.g., roots versus leaves, and with their developmental stage. As animals, pathway synthesis plants utilizes tryptophan as essential precursor molecule. inducible when they are exposed to abiotic stresses (extremes temperature, toxins, increased soil salinity, drought, etc.) well biotic (fungal infection). aids root growth, leaf morphology, chlorophyll preservation fruit development. There also evidence exogenously-applied improves seed germination, growth crop yield its application products post-harvest shows ripening may improve food quality. Since was only discovered two decades ago, there still a great deal learn about functional significance It hope authors current will serve stimulus for scientists join endeavor clarifying function this phylogenetically-ancient particularly reference mechanisms by which mediates multiple actions.

Language: Английский

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