Frontiers in Cellular Neuroscience, Journal Year: 2024, Volume and Issue: 18
Published: Dec. 5, 2024
The pathophysiological role of Aβ
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 6928 - 6928
Published: June 25, 2024
Air pollution, a growing concern for public health, has been linked to various respiratory and cardiovascular diseases. Emerging evidence also suggests link between exposure air pollutants neurodegenerative diseases, particularly Alzheimer's disease (AD). This review explores the composition sources of pollutants, including particulate matter, gases, persistent organic heavy metals. The pathophysiology AD is briefly discussed, highlighting role beta-amyloid plaques, neurofibrillary tangles, genetic factors. article examines how reach brain exert their detrimental effects, delving into neurotoxicity pollutants. molecular mechanisms linking pollution neurodegeneration are explored in detail, focusing on oxidative stress, neuroinflammation, protein aggregation. Preclinical studies, vitro experiments animal models, provide direct effects neuronal cells, glial blood-brain barrier. Epidemiological studies have reported associations an increased risk cognitive decline. body supporting as modifiable factor underscores importance considering environmental factors etiology progression face worsening global quality.
Language: Английский
Citations
5
hLife, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
0
Journal of Neuroimmune Pharmacology, Journal Year: 2025, Volume and Issue: 20(1)
Published: Feb. 7, 2025
Alzheimer's disease (AD) is the most common cause of dementia worldwide, characterized by accumulation amyloid-β protein and hyperphosphorylated tau in brain. Neuroinflammation, resulting from chronic activation brain-resident innate immune cells as well enhanced peripheral leukocyte access across blood-brain barrier, crucially affects AD progression. In this context, TNFSF10, a cytokine substantially expressed brain, has been shown to modulate both adaptive branches response AD-related neuroinflammation. study, we explored whether TNFSF10-neutralizing treatment could represent tool re-balance overall overshooting inflammatory mouse model AD. Specifically, 3xTg-AD mice were treated sub-chronically with an anti-TNFSF10 monoclonal antibody for three months, then sacrificed at 15 months. TNFSF10 neutralization reduced expression marker CD86, inversely related levels anti-inflammatory CD206 brain mice, suggesting switch microglia towards neuroprotective phenotype. Similar results observed splenic macrophage population. Moreover, flow cytometry revealed significant decrease CD4+CD25+FOXP3+ T regulatory number CD11b+LY6Chigh proinflammatory monocytes spleen antibody. Finally, resulted lower count CD4+ CD8+ expressing PD1. The data suggest that system-targeted effectively restrain central inflammation rebalancing response, mitigating progression pathology.
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: Feb. 14, 2025
Microglia, the resident immune cells of central nervous system, continuously monitor brain’s microenvironment through their array specific receptors. Once brain function is altered, microglia are recruited to sites perform functions, including phagocytosis misfolded proteins, cellular debris, and apoptotic maintain homeostasis. When toxic substances overproduced, over-activated produce large amounts pro-inflammatory cytokines, which induce chronic inflammatory responses lead neurotoxicity. Additionally, can also protect neuronal microglia-neuron crosstalk. Microglia receptors important mediators for receive external stimuli, regulate functional state microglia, transmit signals between cells. In this paper, we first review role microglia-expressed in pathogenesis treatment Alzheimer’s disease; moreover, emphasize complexity targeting therapeutic interventions neurodegenerative disorders inform discovery new biomarkers development innovative therapeutics
Language: Английский
Citations
0
International Journal of Environmental Studies, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 19
Published: Feb. 18, 2025
Language: Английский
Citations
0
ACS Omega, Journal Year: 2025, Volume and Issue: 10(9), P. 9132 - 9153
Published: Feb. 24, 2025
Alzheimer's disease (AD) presents a significant challenge due to cognitive decline resulting from nerve cell degeneration. Shatavarin IV, prominent bioactive compound fromAsparagus racemosus and Piracetam, has been investigated for its neuroprotective potential. This study examines the molecular docking, formulation, characterization of nanoemulsion containing Piracetam IV treating AD. The in silico demonstrated that exhibited strong binding affinities with multiple AD-related targets, including TNF-α (−7.29 kcal/mol), GSK-3 axin complex (−9.6785 amyloid-β (−6.8326 β (−8.8243 kcal/mol). extraction Asparagus roots yielded 401.1 ± 2.3 mg purity 66%, as confirmed by HPTLC. A combination index revealed synergistic effect CI value 0.10843 at 1:1 ratio IV. was optimized using Box-Behnken design, oil concentration, surfactant mixture (Smix), sonication time key factors. formulation particle size 183.6 nm PDI 0.194. Characterization techniques, TEM DSC, uniformity, stability, incorporation drugs nanoemulsion. vitro drug release significantly higher profile (84.30 1.03% 24 h) than suspension. Ex vivo studies superior permeability rate (56.35 1.19%) compared conventional Additionally, showed enhanced antioxidant activity pure extract. Stability indicated remained stable only minor changes size, PDI, zeta potential over time. promising therapeutic strategy
Language: Английский
Citations
0
Exploration of neuroscience, Journal Year: 2025, Volume and Issue: 4
Published: Feb. 25, 2025
Alzheimer’s disease (AD) is a neurodegenerative disorder that affects millions of people worldwide. It presents significant challenge in terms accurate diagnosis, progression monitoring, and the development effective treatments. This article addresses role neuroimaging as an advancing tool for monitoring progression, treatment AD. A comprehensive review existing literature on use AD was conducted using various databases. The different imaging techniques, such magnetic resonance (MRI), single photon emission computed tomography (SPECT), positron (PET), were examined their ability to detect amyloid beta (Aβ) plaques neurofibrillary tangles (NFTs), hallmark pathological features Neuroimaging enables visualization Alzheimer-related biomarkers, Aβ plaques, tau protein tangles, neuro-inflammation, synaptic dysfunction, providing valuable insights into pathophysiology progression. These techniques assist early detection AD, distinguishing it from other conditions evaluating effectiveness has potential significantly transform way managed clinically. By molecular changes occur brain during course disease, can facilitate monitor inform decisions. Furthermore, holds great accelerating drug by allowing researchers assess efficacy novel therapies real time. Overall, integration clinical management revolutionize we approach treatment, research
Language: Английский
Citations
0
Molecular Psychiatry, Journal Year: 2025, Volume and Issue: unknown
Published: March 6, 2025
Neuroinflammation is associated with both early and late stages of the pathophysiology Alzheimer's disease (AD). Fluid biomarkers are gaining significance in clinical practice for diagnosis presymptomatic stages, monitoring, prognosis. This systematic literature review (SLR) aimed to identify fluid neuroinflammation related across AD continuum examined long-term outcomes changes biomarkers. The SLR was conducted per Cochrane Handbook Systematic Reviews Interventions Preferred Reporting Items Meta-Analyses (PRISMA) guidelines. We used PubMed®, Embase®, Collaboration databases search articles English (between 2012 2022) on or mild cognitive impairment due AD, using "neuroinflammation" other "immune" strings. Two independent reviewers screened titles data from full-text SLR. After initial screening, 54 studies were prioritized extraction based upon their relevance research questions. Nine YKL-40, seven sTREM2, 11 GFAP relationship between neuroinflammatory stage disease. longitudinal further explored association Cerebrospinal (CSF) levels YKL-40 elevated patients dementia, while CSF sTREM2 more strongly preclinical symptomatic AD. Plasma remained consistently dementia individuals β-amyloid pathology. Longitudinal plasma appeared be predictive decline over time. Neuroinflammatory progression. More MCI needed validate diagnosis, prognosis practice.
Language: Английский
Citations
0
Virology, Journal Year: 2025, Volume and Issue: unknown, P. 110523 - 110523
Published: March 1, 2025
Language: Английский
Citations
0
Journal of Neuroimmune Pharmacology, Journal Year: 2025, Volume and Issue: 20(1)
Published: March 31, 2025
Language: Английский
Citations
0