Asian Journal of Psychiatry, Journal Year: 2024, Volume and Issue: 103, P. 104312 - 104312
Published: Nov. 20, 2024
Language: Английский
Current Opinion in Neurology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 7, 2025
Purpose of review This focuses on the role psychological factors in cognitive aging and dementia, an area that has received less attention compared to other modifiable (e.g. sleep, physical activity, so on) or reduction disease risk. Recent findings A range mental health aspects, including clinical symptoms, stable personality traits, more specific constructs processes repetitive negative thinking, purpose life), are associated with dementia Psychological can either serve as protective risk elements, influencing brain through general mechanisms, stress regulation impact several biological systems, well modulate resistance resilience Alzheimer's age-related changes. Protective traits linked healthier lifestyle habits, while behaviors, may function across lifespan, suggesting benefits for education from early life. Summary The emphasizes need greater focus optimizing being, particularly at-risk populations, suggests interventions should be tailored individuals’ values life purposes. Additionally, further research is needed explore neurobiological mechanisms which psychologically focused influence decline dementia.
Language: Английский
Citations
1
PLoS ONE, Journal Year: 2025, Volume and Issue: 20(3), P. e0311074 - e0311074
Published: March 27, 2025
Background Dementia is a major public health concern, with its incidence rising as the population ages. Recent studies suggest links between childhood health, socioeconomic status, and later-life cognitive impairment dementia, though findings remain inconclusive. This systematic review evaluates influence of status on dementia. Method A search conducted in MEDLINE, CiNAHL, PsycINFO December 2024 identified 44 matching our inclusion criteria. Findings are presented under five key themes: (1) (2) educational attainment, (3) family factors, (4) experiences, (5) reading habits social interactions. Conclusion Our results highlight need for further longitudinal to establish causal relationships early-life risk factors later decline. Policymakers should prioritize early development programs that integrate nutrition, education, support help mitigate dementia life.
Language: Английский
Citations
1
medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown
Published: April 20, 2025
Early life is a critical period for brain development, laying the foundation cognitive reserve. However, it remains unclear how various aspects of early relate to dementia risk, and they may interact with genetic predisposition. This study leverages data on nationally representative older adults in United States from Health Retirement Study (2006-2020; N=8,676; ages ≥ 60 at baseline, 55% female). We used Cox proportional hazards models evaluate associations risk factors (financial, social, human capital deficits, adverse experiences, childhood health conditions) their interactions APOE ε4 genotype incidence. Low early-life financial, capital, as well conditions were associated higher risk. After adjusting comprehensive adulthood factors, low social persisted significant predictors, 16% (95% CI=1-34%) 21% CI=6-38%) increased risks, respectively. strongly predicted across all (83-86% risk). Notably, emerged between financial adversity. These significantly only among non-carriers. Carrying ε4, however, consistently elevated regardless socioeconomic status or adversity exposure. Our findings suggest potential direct, enduring impacts inadequate resources, show that predisposition via overwhelm influence adversity, providing evidence consistent differential susceptibility hypothesis.
Language: Английский
Citations
0
Asian Journal of Psychiatry, Journal Year: 2024, Volume and Issue: 103, P. 104312 - 104312
Published: Nov. 20, 2024
Language: Английский
Citations
0