Microbiome Research Reports,
Journal Year:
2023,
Volume and Issue:
3(2)
Published: Dec. 25, 2023
Population
aging
is
a
substantial
challenge
for
the
global
sanitation
framework.
Unhealthy
tends
to
be
accompanied
by
chronic
diseases
such
as
cardiovascular
disease,
diabetes,
and
cancer,
which
undermine
welfare
of
elderly.
Based
on
fact
that
inevitable
but
retarding
attainable,
flexible
characterization
efficient
anti-aging
become
imperative
healthy
aging.
The
gut
microbiome,
most
dynamic
component
interacting
with
organism,
can
affect
process
through
its
own
structure
metabolites,
thus
holding
potential
both
an
ideal
aging-related
biomarker
intervention
strategy.
This
review
summarizes
value
applying
microbiota
microbial
biomarkers
in
diagnosing
state
monitoring
effect
interventions,
ultimately
pointing
future
prospects
strategies
maintaining
Microbes and Infection,
Journal Year:
2024,
Volume and Issue:
26(3), P. 105309 - 105309
Published: Feb. 4, 2024
This
review
explores
'microb-aging'
in
the
gut
and
its
potential
link
to
frailty
aging.
We
explore
this
connection
through
alterations
microbiota's
taxonomy
metabolism,
as
well
with
concepts
of
ecological
resilience,
pathobionts
emergence,
biogeography.
examine
microb-aging
interconnected
body
organs,
emphasizing
bidirectional
relationship
'inflammaging'.
Finally,
we
discuss
how
targeting
could
improve
screening,
diagnostic,
therapeutic
approaches
geriatrics.
European journal of medical research,
Journal Year:
2023,
Volume and Issue:
28(1)
Published: Sept. 12, 2023
Abstract
Background
Renal
cell
carcinoma
(RCC)
is
a
malignant
tumour
that
may
develop
in
the
kidney.
RCC
one
of
most
common
kinds
tumours
this
sort,
and
its
pathological
subtype
kidney
renal
clear
(KIRC).
However,
aetiology
pathogenesis
still
need
to
be
clarified.
Exploring
internal
mechanism
contributes
diagnosing
treating
disease.
Pyroptosis
critical
process
related
death.
Recent
research
has
shown
pyroptosis
factor
initiation
progression
formation.
Thus
far,
researchers
have
progressively
uncovered
evidence
regulatory
influence
long
noncoding
RNAs
(lncRNAs)
on
pyroptosis.
Methods
In
work,
comprehensive
bioinformatics
approach
was
used
produce
predictive
model
according
pyroptosis-interrelated
lncRNAs
for
purpose
predicting
overall
survival
molecular
immune
specialties
patients
diagnosed
with
KIRC.
This
verified
from
multiple
perspectives.
Results
First,
we
discovered
pyroptosis-associated
KIRC
using
TCGA
database
Sankey
diagram.
Then,
developed
validated
patient
risk
based
pyroptosis-related
lncRNAs.
We
demonstrated
grouping
power
PLnRM
through
PCA
assess
microenvironment
response
immunotherapy.
Immunological
traits
diverse
subgroups
were
evaluated,
as
clinical
characteristics
models.
On
basis,
nomogram
analyzed,
novel
candidate
compounds
identified.
Finally,
investigated
possible
medications
by
patients.
Conclusions
The
results
demonstrate
generated
significant
value
practice.
Immunological Reviews,
Journal Year:
2024,
Volume and Issue:
325(1), P. 166 - 189
Published: June 18, 2024
The
human
gut
microbiome
is
well-recognized
as
a
key
player
in
maintaining
health.
However,
it
dynamic
entity
that
changes
across
the
lifespan.
How
microbial
occur
later
decades
of
life
shape
host
health
or
impact
age-associated
inflammatory
neurological
diseases
such
multiple
sclerosis
(MS)
still
unclear.
Current
understanding
aging
largely
limited
to
cross-sectional
observational
studies.
Moreover,
studies
humans
are
by
confounding
host-intrinsic
and
extrinsic
factors
not
easily
disentangled
from
aging.
This
review
provides
comprehensive
summary
existing
literature
on
its
known
relationships
with
diseases,
specific
focus
MS.
We
will
also
discuss
preclinical
animal
models
shed
light
complex
microbiota-host
interactions
have
potential
influence
disease
pathology
progression
individuals.
Lastly,
we
propose
avenues
investigation
deconvolute
features
an
microbiota
contribute
disease,
alternatively
promote
advanced
age.
Gut Microbes,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: Dec. 9, 2024
Previous
research
has
established
a
link
between
gut
microbiota
and
osteoporosis
(OP)
advancement.
However,
there
remains
limited
understanding
of
the
crucial
contribution
virome
in
onset
progression
OP.
We
employed
metagenomic
shotgun
sequencing
to
process
ovariectomy
(OVX)-induced
OP
murine
model,
which
revealed
significant
disparities
bacteriome
compositions
subjects
with
healthy
controls.
One
hundred
seventy-four
altered
viral
strains
were
identified
participate
multifaceted
regulation
bone
loss,
involving
immune
modulation,
microbial
metabolic
activity,
intricate
host-virus
dynamics.
Our
findings
suggested
that
may
influence
metabolism,
potentially
altering
balance
bone-modulating
compounds
like
short-chain
fatty
acids.
This
comprehensive
analysis
highlighted
diagnostic
potential
combined
bacterial
biomarkers
for
Journal of Multidisciplinary Healthcare,
Journal Year:
2023,
Volume and Issue:
Volume 16, P. 2863 - 2872
Published: Sept. 1, 2023
Abstract:
Coronavirus
disease
2019
is
a
"Public
Health
Emergency
of
International
Concern"
from
30
January
2020
to
5
May
2023.
While
battling
2019,
the
Chinese
government
has
actively
promoted
collaborative
treatment
model
Western
medicine
and
traditional
medicine,
clinical
scientific
research
applied
appropriate
rigorous
methodology.
Severe
acute
respiratory
syndrome
coronavirus
2
infection
may
damage
cardiovascular
system
via
an
unclarified
pathogenic
mechanism.
The
National
Commission
China
recommends
'three
formulas
three
medicines'
for
which
have
been
shown
be
most
effective
in
treatments.
Data
randomized
controlled
trials
suggested
that
safe
can
alleviate
symptoms
cardiac
injury.
Therefore,
we
further
evaluate
benefits
safety
patients
with
injury
across
care
continuum.
Keywords:
Microbiome Research Reports,
Journal Year:
2023,
Volume and Issue:
3(2)
Published: Dec. 25, 2023
Population
aging
is
a
substantial
challenge
for
the
global
sanitation
framework.
Unhealthy
tends
to
be
accompanied
by
chronic
diseases
such
as
cardiovascular
disease,
diabetes,
and
cancer,
which
undermine
welfare
of
elderly.
Based
on
fact
that
inevitable
but
retarding
attainable,
flexible
characterization
efficient
anti-aging
become
imperative
healthy
aging.
The
gut
microbiome,
most
dynamic
component
interacting
with
organism,
can
affect
process
through
its
own
structure
metabolites,
thus
holding
potential
both
an
ideal
aging-related
biomarker
intervention
strategy.
This
review
summarizes
value
applying
microbiota
microbial
biomarkers
in
diagnosing
state
monitoring
effect
interventions,
ultimately
pointing
future
prospects
strategies
maintaining
