Role of Neurotropic Viruses in Brain Metastasis of Breast Cancer: Mechanisms and Therapeutic Implications DOI

Ziran Qiu,

Xinyu Liu, Wenqing Cao

et al.

Reviews in Medical Virology, Journal Year: 2024, Volume and Issue: 34(5)

Published: Sept. 1, 2024

ABSTRACT Neurotropic viruses have been implicated in altering the central nervous system microenvironment and promoting brain metastasis of breast cancer through complex interactions involving viral entry mechanisms, modulation blood–brain barrier, immune evasion, alteration tumour microenvironment. This narrative review explores molecular mechanisms by which neurotropic such as Herpes Simplex Virus, Human Immunodeficiency Japanese Encephalitis Rabies Virus facilitate metastasis, focusing on their ability to disrupt barrier integrity, modulate responses, create a permissive environment for metastatic cell survival growth within system. Current therapeutic implications challenges targeting prevent or treat are discussed, highlighting need innovative strategies multidisciplinary approaches virology, oncology, immunology.

Language: Английский

Morpho-phenotypic characterization of melanoma brain metastases immune microenvironment: a multicentre retrospective study DOI Creative Commons
Filippo Nozzoli, Marco Gessi, Filippo Ugolini

et al.

EJC Skin Cancer, Journal Year: 2024, Volume and Issue: 2, P. 100263 - 100263

Published: Jan. 1, 2024

Language: Английский

Citations

1
Metastatic brain tumors: from development to cutting‐edge treatment DOI Creative Commons
Guilong Tanzhu,

Liu Chen,

Jiaoyang Ning

et al.

MedComm, Journal Year: 2024, Volume and Issue: 6(1)

Published: Dec. 20, 2024

Abstract Metastatic brain tumors, also called metastasis (BM), represent a challenging complication of advanced tumors. Tumors that commonly metastasize to the include lung cancer and breast cancer. In recent years, prognosis for BM patients has improved, significant advancements have been made in both clinical preclinical research. This review focuses on originating from We briefly overview history epidemiology BM, as well current diagnostic treatment paradigms. Additionally, we summarize multiomics evidence mechanisms tumor occurrence development era artificial intelligence discuss role microenvironment. Preclinically, introduce establishment models, detailed molecular mechanisms, cutting‐edge methods. is primarily treated with comprehensive approach, including local treatments such surgery radiotherapy. For cancer, targeted therapy immunotherapy shown efficacy, while monoclonal antibodies, tyrosine kinase inhibitors, antibody–drug conjugates are effective BM. Multiomics approaches assist diagnosis treatment, revealing complex Moreover, agents often need cross blood–brain barrier achieve high intracranial concentrations, small‐molecule nanoparticles, peptide drugs. Addressing imperative.

Language: Английский

Citations

1
The emerging role of immune checkpoint blockade for the treatment of lung cancer brain metastases DOI
Xiancheng Wu, Laura P. Stabile, Timothy F. Burns

et al.

Clinical Lung Cancer, Journal Year: 2024, Volume and Issue: 25(6), P. 483 - 501

Published: June 12, 2024

Language: Английский

Citations

0
The interplay between breast cancer and the nervous system during the progression of breast cancer and implications for its targeted therapy DOI Creative Commons

Guocui Cai,

Feiyang Songa

BIO Web of Conferences, Journal Year: 2024, Volume and Issue: 124, P. 02015 - 02015

Published: Jan. 1, 2024

Breast cancer ranks as a leading cause of cancer-related deaths in women globally. Current treatments often fall short eradicating it completely, posing challenges managing its incidence and mortality rates. The nervous system significantly influences breast initiation, progression, metastasis. review highlights how the hypothalamic-pituitary-adrenal axis central peripheral nerves, such parasympathetic sympathetic can either promote or inhibit development through neurotransmitter release. Understanding these mechanisms offers new therapeutic targets, potentially improving diagnosis treatment strategies.

Language: Английский

Citations

0
T lymphocyte-derived IFN-γ facilitates breast cancer cells to pass the blood-brain barrier: An in vitro study corroborating translational data DOI Creative Commons

Rute M. S. M. Pedrosa,

Johan M. Kros, Benjamin Schrijver

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(16), P. e36598 - e36598

Published: Aug. 1, 2024

Language: Английский

Citations

0
BRAIN-METASTATIC MELANOMA MODELS UNCOVER IMMUNE AND MOLECULAR CORRELATES OF RESPONSE TO IMMUNOTHERAPY DOI Creative Commons
Amélie Lopès, Eva Pérez‐Guijarro,

Vishaka Gopalan

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 28, 2024

SUMMARY Despite the promising results of immune checkpoint blockade (ICB) therapy, outcomes for patients with brain metastasis (BrM) remain poor. Identifying resistance mechanisms has been hindered by limited access to patient samples and relevant preclinical models. Here, we developed two mouse melanoma BrM models that recapitulate disparate responses ICB seen in patients. We demonstrate these capture cellular molecular complexity human disease reveal key factors shaping tumor microenvironment influencing response. BR1-responsive cells express inflammatory programs polarize microglia into reactive states, eliciting robust T cell recruitment. In contrast, BR3-resistant are enriched neurological exploit tolerance maintain homeostasis limit infiltration. humans, BR1 BR3 expression signatures correlate positively or negatively infiltration outcomes, respectively. Our study provides clinically uncovers mechanistic insights responses, offering potential biomarkers therapeutic targets improve therapy efficacy.

Language: Английский

Citations

0
Role of Neurotropic Viruses in Brain Metastasis of Breast Cancer: Mechanisms and Therapeutic Implications DOI

Ziran Qiu,

Xinyu Liu, Wenqing Cao

et al.

Reviews in Medical Virology, Journal Year: 2024, Volume and Issue: 34(5)

Published: Sept. 1, 2024

ABSTRACT Neurotropic viruses have been implicated in altering the central nervous system microenvironment and promoting brain metastasis of breast cancer through complex interactions involving viral entry mechanisms, modulation blood–brain barrier, immune evasion, alteration tumour microenvironment. This narrative review explores molecular mechanisms by which neurotropic such as Herpes Simplex Virus, Human Immunodeficiency Japanese Encephalitis Rabies Virus facilitate metastasis, focusing on their ability to disrupt barrier integrity, modulate responses, create a permissive environment for metastatic cell survival growth within system. Current therapeutic implications challenges targeting prevent or treat are discussed, highlighting need innovative strategies multidisciplinary approaches virology, oncology, immunology.

Language: Английский

Citations

0