Genetic Risk, Inflammation, and Therapeutics: An Editorial Overview of Recent Advances in Aging Brains and Neurodegeneration DOI Creative Commons
Vivek Gupta, Nitin Chitranshi, Veer Bala Gupta

et al.

Aging and Disease, Journal Year: 2024, Volume and Issue: 15(5), P. 1989 - 1989

Published: Jan. 1, 2024

Neurodegenerative disorders, including Dementia, Parkinson's disease, various Vision Multiple sclerosis, and transsynaptic degenerative changes represent a significant challenge in aging populations. This editorial synthesizes discusses recent advancements understanding the genetic environmental factors contributing to these diseases. Central is role of neuroinflammation oxidative stress, which exacerbate neuronal damage accelerate disease progression. Emerging research underscores significance mitochondrial dysfunction protein aggregation neurodegenerative pathology, highlighting shared mechanisms across disorders. Innovative therapeutic strategies, gene therapy, CRISPR-Cas technology, use naturally occurring antioxidant molecules, are being investigated target manage conditions. Additionally, lifestyle interventions such as exercise healthy diet have shown promise enhancing brain plasticity reducing neuroinflammation. Advances neuroimaging biomarker discovery necessary improve early diagnosis, while clinical preclinical studies essential for translation novel treatments. edition aims bridge gap between molecular applications, offering insights into potential mitigate impact By establishing deeper complex processes, we aim move closer effective prevention treatment ultimately improving quality life those affected by

Language: Английский

The role of retinal pigment epithelial senescence and the potential of senotherapeutics in age-related macular degeneration DOI
Yingying Chen,

Feipeng Jiang,

Yue Zeng

et al.

Survey of Ophthalmology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Pten Loss Triggers Progressive Photoreceptor Degeneration in an mTORC1-Independent Manner DOI Creative Commons

Joseph Hanna,

Yacine Touahri,

Alissa Pak

et al.

Investigative Ophthalmology & Visual Science, Journal Year: 2025, Volume and Issue: 66(3), P. 45 - 45

Published: March 21, 2025

Purpose: Silencing Phosphatase and tensin homolog (Pten) is a proposed therapeutic strategy for tissue regeneration to treat neurological disorders. However, Pten pleiotropic, inhibiting several signaling metabolic pathways, including mTORC1 glycolysis, both pro-regenerative in certain contexts. This study aims assess the long-term impact of inactivating on photoreceptor survival retina identify downstream pathway(s). Methods: We assessed retinal integrity conditional knock-outs (cKOs) that were progenitor cell (RPC)-specific (Pten RPC-cKO), congenital model, or rod-specific Rho-cKO). examined early changes gene expression used immunostaining photoreceptors, reactive astrocytes, microglia, angiogenesis, subretinal deposit formation from postnatal day (P) 21 1 year age. RPC-cKO explants treated with rapamycin, an mTOR inhibitor, 2-deoxy-D-glucose (2DG), glycolysis inhibitor. Results: In Pten-cKO models, retinas display signs pathogenesis as photoreceptor-specific downregulated at P0, before loss. loss triggers progressive rod cone degeneration beginning P21 RPC-cKOs 6 months age Rho-cKOs. Activated microglia increased are observed while amyloid-β deposits develop RPC-cKOs. Rapamycin accelerates RPC-cKOs, whereas 2DG has no effect. Conclusions: Our findings suggest loss, either RPCs solely mature leads exacerbated by suppression, drawing into question value Pten-mTORC1 manipulations.

Language: Английский

Citations

0
Genetic Risk, Inflammation, and Therapeutics: An Editorial Overview of Recent Advances in Aging Brains and Neurodegeneration DOI Creative Commons
Vivek Gupta, Nitin Chitranshi, Veer Bala Gupta

et al.

Aging and Disease, Journal Year: 2024, Volume and Issue: 15(5), P. 1989 - 1989

Published: Jan. 1, 2024

Neurodegenerative disorders, including Dementia, Parkinson's disease, various Vision Multiple sclerosis, and transsynaptic degenerative changes represent a significant challenge in aging populations. This editorial synthesizes discusses recent advancements understanding the genetic environmental factors contributing to these diseases. Central is role of neuroinflammation oxidative stress, which exacerbate neuronal damage accelerate disease progression. Emerging research underscores significance mitochondrial dysfunction protein aggregation neurodegenerative pathology, highlighting shared mechanisms across disorders. Innovative therapeutic strategies, gene therapy, CRISPR-Cas technology, use naturally occurring antioxidant molecules, are being investigated target manage conditions. Additionally, lifestyle interventions such as exercise healthy diet have shown promise enhancing brain plasticity reducing neuroinflammation. Advances neuroimaging biomarker discovery necessary improve early diagnosis, while clinical preclinical studies essential for translation novel treatments. edition aims bridge gap between molecular applications, offering insights into potential mitigate impact By establishing deeper complex processes, we aim move closer effective prevention treatment ultimately improving quality life those affected by

Language: Английский

Citations

1