The role of phase separation in RNA modification: Both cause and effect

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 135907 - 135907

Published: Sept. 1, 2024

Language: Английский

Drug Screening and Validation Targeting TDP-43 Proteinopathy for Amyotrophic Lateral Sclerosis

Aging and Disease, Journal Year: 2024, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2024

Amyotrophic lateral sclerosis (ALS) stands as a rare, yet severely debilitating disorder marked by the deterioration of motor neurons (MNs) within brain and spinal cord, which is accompanied degenerated corticobulbar/corticospinal tracts denervation in skeletal muscles. Despite ongoing research efforts, ALS remains incurable, attributed to its intricate pathogenic mechanisms. A notable feature pathology prevalence TAR DNA-binding protein 43 (TDP-43) proteinopathy, detected approximately 97% cases, underscoring significance disease's progression. As result, strategies targeting aberrant TDP-43 have garnered attention potential avenue for therapy. This review delves into existing drug screening systems aimed at proteinopathy models employed efficacy validation. It also explores hurdles encountered quest develop potent medications against offering insights intricacies discovery development ALS. Through this comprehensive analysis, sheds light on critical aspects identifying advancing therapeutic solutions

Language: Английский

Pan-cancer analysis of m1A writer gene RRP8: implications for immune infiltration and prognosis in human cancers

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Sept. 12, 2024

Ribosomal RNA Processing 8 (RRP8) is a gene associated with modification and has been implicated in the development of several types tumors recent research. Nevertheless, biological importance RRP8 pan-cancer not yet thoroughly comprehensively investigated.

Language: Английский