Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Dec. 23, 2024
Background
Post-stroke
depression
(PSD)
is
the
most
prevalent
neuropsychiatric
complication
following
a
stroke.
The
inflammatory
theory
suggests
that
PSD
may
be
associated
with
an
overactive
response.
However,
research
findings
regarding
inflammation-related
indicators
in
remain
inconsistent
and
elusive.
This
study
aimed
to
screen
diagnostic
markers
helps
distinguish
between
post-stroke
non-depressed
(PSND)
patients.
Methods
Two
GEO
datasets,
including
patients
major
disease
(MDD)
controls
(CON,
GSE98793),
ischemic
stroke
(IS)
CON
(GSE16561),
were
used
analyzed
differentially
expressed
genes
(DEGs)
perform
enrichment
analysis.
Protein-protein
interaction
(PPI)
network
Random
Forest
analysis
candidate
hub
genes.
CIBERSORT
was
performed
analyze
immune
infiltration.
We
proteins
interact
using
string
database,
circRNA-miRNA-mRNA
ceRNA
of
RNAInter,
miRWalk,
miRDB
Starbase
databases,
drugs
regulate
by
DSigDB
database.
further
verified
expression
Quantitative
Real-Time
PCR
from
blood
CON.
Results
From
screened
394
DEGs,
DEGs
found
primarily
related
activation
PPI
random
forest
obtained
genes:
IL-7R.
ROC
showed
IL-7R
had
good
predictive
effect
on
MDD
IS
proportions
macrophages
M0
monocytes
significantly
higher
than
those
constructed
perturbagen
signatures
computational
drug
can
target
MDD,
PSND
lower
CON,
Conclusion
These
indicate
serve
as
marker
patients,
targeting
therapeutic
could
potentially
improve
treatment
outcomes
for
PSD.
Research Square (Research Square),
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 19, 2025
Abstract
Post-stroke
depression
(PSD)
is
recognized
as
the
most
common
psychiatric
disorder
following
a
stroke,
impacting
subsequent
recovery
and
quality
of
life
stroke
survivors.
In
recent
years,
physical
activities
mindfulness
have
been
proven
to
improve
depression,
however,
it
remained
unknown
whether
those
interventions
were
also
effective
in
treatment
PSD.
This
systematic
review
aims
assess
effects
mind-
body-based
on
PSD
their
underlying
neural
mechanisms.
The
(PROSPERO
registration
number:
CRD42024514565)
searched
CINAHL,
Cochrane,
PsycINFO,
PubMed,
Scopus
up
March
11,
2024,
focusing
English-language
studies.
Inclusion
criteria
encompassed
randomized
controlled
trials
patients
with
using
validated
assessment
tools,
targeting
body-based,
mind-based,
or
mind-body
interventions,
while
excluding
psychological
counseling
passive
movements.
Two
authors
conducted
data
extraction
checks
for
accuracy,
risk
bias
was
assessed
PEDro
scale,
which
evaluates
study
design
methodology,
yielding
maximum
score
10
points.
Data
by
independent
reviewers.
A
total
68
studies
included,
involving
6,825
participants,
54
these
included
meta-analysis.
average
6.51
indicates
good
methodological
quality,
combined
scoring
highest
at
7.44,
highlighting
variability
among
Meta-analysis
results
demonstrate
that
all
significant
impact
(p
<
0.05),
effect
sizes
follows:
(n
=
66,
Hedges’
g
-0.572),
mind-based
4,
-0.549),
52,
-0.532),
10,
-0.805).
meta-analysis
revealed
significantly
improved
post-stroke
are
more
than
alone.
It
suggested
integrate
additional
elements
into
daily
exercises
survivors
clinical
practice
can
further
alleviate
depressive
symptoms.
