Arketamine alleviates cognitive impairments and demyelination in mice with postoperative cognitive dysfunction via TGF-β1 activation DOI Creative Commons
Tingting Zhu,

Mingming Zhao,

Dan Xu

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2024, Volume and Issue: 136, P. 111228 - 111228

Published: Dec. 22, 2024

Postoperative cognitive dysfunction (POCD) is characterized by a decline in functions, including memory, attention, and executive abilities, following surgery, with no effective therapeutic drugs currently available. Arketamine, the (R)-enantiomer of ketamine, has shown promise mitigating deficits animal models. In this study, we investigated whether arketamine could ameliorate mouse model POCD, focus on role transforming growth factor (TGF)-β1 its effects. POCD mice displayed impairments demyelination corpus callosum. A single injection (10 mg/kg) significantly improved both function callosum mice. Notably, pretreatment RepSox mg/kg), TGF-β receptor 1 inhibitor, blocked beneficial effects demyelination. Moreover, intranasal administration TGF-β1 (3.0 μg/kg) markedly alleviated These findings suggest that exerts through TGF-β1-dependent mechanism, positioning it as potential option for POCD.

Language: Английский

Factors associated with physical fitness and disparities in population segments among older adults: A cross-sectional study DOI Creative Commons

Yuqin Rao,

Jingjing Wang, Kai Li

et al.

Journal of Exercise Science & Fitness, Journal Year: 2025, Volume and Issue: 23(1), P. 69 - 76

Published: Jan. 1, 2025

This study aimed to investigate the factors associated with physical fitness and disparities in population segments among older adults, using data from National Physical Fitness Surveilling Survey of China. A cross-sectional study. total 13524 adults aged 60-79 years were involved Participants completed assessments encompassing body fat percentage, lung capacity, high leg raise place, grip strength, seated forward bending, 30-s sit-to-stand test, single-leg standing eyes closed, choice reaction time. profile analysis model was constructed by feature extraction, label design clustering principal component k-prototypes. Factors analyzed ordered probit regression, within-group differences evaluated through bootstrap method. The categorized into four clusters based on results (Cluster I: n = 2728, Cluster II: 6067, III: 4189, IV: 540). Significant positive associations identified between moderate-to-vigorous transport-related activities (α 0.001, p < 0.05), household chores ( α 0.003, 0.01), work-related activity exercise 0.002, 0.01) levels. Conversely, number illnesses -0.089, sedentary behavior -0.002, 0.05) negatively fitness. Inflection points observed, indicating shifts lower level higher levels as volume diverse increased. Disparities across different clusters. chores, activities, lacked robustness during heterogeneity processing. In contrast, consistently demonstrated a facilitating role all Furthermore, greater marginal effects achieving test scores observed individuals classified inactive when engaging more exercise. findings demonstrate that engagement is significantly probability better adults. Participating should be encouraged for precise quantitative interventions improve

Language: Английский

Citations

0
Electroacupuncture promotes oligodendrocyte differentiation and myelin repair in a rat model of vascular dementia: Investigation of the mechanism from NF-κB-mediated inflammation DOI
Chang Liu, Huayi Yin, Xiaoyu Chen

et al.

Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Association between cardiorespiratory fitness and total brain myelin volume among older adults DOI Creative Commons
M. Kujawa, Małgorzata Grzywińska, Angelika K. Sawicka

et al.

European Review of Aging and Physical Activity, Journal Year: 2025, Volume and Issue: 22(1)

Published: April 8, 2025

Abstract Background Myelin, which insulates neurons, speeds up information transfer and provides the necessary conditions for cognitive motor functioning. The direct link between physical performance total brain myelin volume remains unclear. Methods This study involved 87 healthy participants (71 women, 16 men) with a mean age of 69.3 ± 3.14 years body mass index 27.83 3.93 kg/m 2 . Several measures fitness (isometric muscle strength, handgrip cardiopulmonary exercise testing) were examined their correlations using Synthetic MRI, an FDA-approved assessment software. Results A high maximal respiratory exchange ratio low heart rate achieved during testing associated higher estimated content. In addition, strength test as well peak average torque parenchymal volumes. Conclusions We demonstrated that content was positively better cardiorespiratory upper lower limb in older individuals. These findings provide new insights into development improved rehabilitation schemes to preserve health adult population.

Language: Английский

Citations

0
Androgen deprivation exacerbates AD pathology by promoting the loss of microglia in an age-dependent manner DOI
Jia-Xin Cao, Haichao Chen,

Yishu Zhang

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 355, P. 122973 - 122973

Published: Aug. 12, 2024

Language: Английский

Citations

2
Association between cardiometabolic index and biological aging in the US population: evidence from NHANES 2015–2020 DOI Creative Commons
Miao Sun,

Shuang Bao

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Nov. 29, 2024

It is crucial to identify biomarkers that influence the aging process and associated health risks, given growing severity of global population issue. The objectives our research were evaluate cardiac metabolic index (CMI) as a novel biomarker for identifying individuals at increased risk accelerated biological assess its use in guiding preventive strategies aging-related risks.

Language: Английский

Citations

1
Genetic Risk, Inflammation, and Therapeutics: An Editorial Overview of Recent Advances in Aging Brains and Neurodegeneration DOI Creative Commons
Vivek Gupta, Nitin Chitranshi, Veer Bala Gupta

et al.

Aging and Disease, Journal Year: 2024, Volume and Issue: 15(5), P. 1989 - 1989

Published: Jan. 1, 2024

Neurodegenerative disorders, including Dementia, Parkinson's disease, various Vision Multiple sclerosis, and transsynaptic degenerative changes represent a significant challenge in aging populations. This editorial synthesizes discusses recent advancements understanding the genetic environmental factors contributing to these diseases. Central is role of neuroinflammation oxidative stress, which exacerbate neuronal damage accelerate disease progression. Emerging research underscores significance mitochondrial dysfunction protein aggregation neurodegenerative pathology, highlighting shared mechanisms across disorders. Innovative therapeutic strategies, gene therapy, CRISPR-Cas technology, use naturally occurring antioxidant molecules, are being investigated target manage conditions. Additionally, lifestyle interventions such as exercise healthy diet have shown promise enhancing brain plasticity reducing neuroinflammation. Advances neuroimaging biomarker discovery necessary improve early diagnosis, while clinical preclinical studies essential for translation novel treatments. edition aims bridge gap between molecular applications, offering insights into potential mitigate impact By establishing deeper complex processes, we aim move closer effective prevention treatment ultimately improving quality life those affected by

Language: Английский

Citations

0
The Potential Related Genes and Mechanisms Involved in Improving the Treadmill Exercise Ability of APP/PS1 Mice DOI Open Access
Zhe Zhao,

Xingqing Wu,

Weijia Wu

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10244 - 10244

Published: Sept. 24, 2024

Alzheimer’s disease (AD) causes a decline in skeletal muscle function, which can further exacerbate the cognitive dysfunction of patients with AD. It has been widely established that exercise improves AD brain pathology, but role is still poorly understood. In this study, we investigated effects treadmill on ability APP/PS1 transgenic mice and explored potential gene expression changes their muscle. The were subjected to for 12 weeks, followed by Morris water maze open field test. After behavioral experiments, morphology, area, collagen fiber deposition, ultrastructure determined; balance protein synthesis decomposition was analyzed; using RNA-Seq. We found strategy promote learning memory abilities mice, reduce anxiety-like behavior, improve ability, alleviate atrophy, optimize microstructure. also enhance several signaling pathways, such as JAK–STAT, Wnt, NOD-like receptors while decreasing calcium, cAMP, cGMP–PKG, other pathways. Six KEGG enrichment pathways downregulated five upregulated compared wild-type these precisely reversed after exercise. transcription factors Fosb Egr1 decreased, decrease regulated target genes Socs1, Srrm4, Il1b, trend following intervention. exercise, exhibited similar indicating enhanced ability. regulatory related identified study provide valuable insights clinical management treatment

Language: Английский

Citations

0
Arketamine alleviates cognitive impairments and demyelination in mice with postoperative cognitive dysfunction via TGF-β1 activation DOI Creative Commons
Tingting Zhu,

Mingming Zhao,

Dan Xu

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2024, Volume and Issue: 136, P. 111228 - 111228

Published: Dec. 22, 2024

Postoperative cognitive dysfunction (POCD) is characterized by a decline in functions, including memory, attention, and executive abilities, following surgery, with no effective therapeutic drugs currently available. Arketamine, the (R)-enantiomer of ketamine, has shown promise mitigating deficits animal models. In this study, we investigated whether arketamine could ameliorate mouse model POCD, focus on role transforming growth factor (TGF)-β1 its effects. POCD mice displayed impairments demyelination corpus callosum. A single injection (10 mg/kg) significantly improved both function callosum mice. Notably, pretreatment RepSox mg/kg), TGF-β receptor 1 inhibitor, blocked beneficial effects demyelination. Moreover, intranasal administration TGF-β1 (3.0 μg/kg) markedly alleviated These findings suggest that exerts through TGF-β1-dependent mechanism, positioning it as potential option for POCD.

Language: Английский

Citations

0