Ketamine in insulin resistance: Pharmacokinetics, cardiovascular implications and cellular effects on cardiomyocytes

Diabetes Obesity and Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

Abstract Ketamine, a dissociative anaesthetic, has expanded its clinical use beyond anaesthesia to pain management and treatment‐resistant depression. As an N ‐methyl‐ d ‐aspartate receptor antagonist, ketamine disrupts the excitatory neurotransmission via interaction with opioid, alpha‐amino‐3‐hydroxy‐5‐methyl‐4‐isooxazole‐propionic acid serotonin pathways, contributing broad therapeutic potential. However, is not without risks. In patients insulin resistance, ketamine's effect on glucose metabolism, mitochondrial function oxidative stress are exacerbated. This paper explores pharmacokinetics, cardiovascular impact cellular effects cardiomyocytes, particularly in insulin‐resistant individuals. The findings discussed emphasize importance of careful administration monitoring these vulnerable populations balance benefits against potential risks underlying metabolic or conditions.

Language: Английский

Melatonin’s Impact on Cytokine Storm and Modulation of Purinergic Receptors for COVID-19 Prognosis: A Mental Health Perspective

Journal of Molecular Neuroscience, Journal Year: 2024, Volume and Issue: 74(4)

Published: Dec. 5, 2024

Language: Английский

The Influence of the Duration of Chronic Unpredictable Mild Stress on the Effectiveness of Modeling Depressive-Like State in Rats of Different Ages

Journal of Evolutionary Biochemistry and Physiology, Journal Year: 2024, Volume and Issue: 60(6), P. 2504 - 2516

Published: Nov. 1, 2024

Language: Английский