Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)
Published: Oct. 9, 2024
Recent studies have established a correlation between ADAMTSL2 (ADAMTS-like 2) and the development of various cancers. This study aims to conduct comprehensive pan-cancer analysis in 37 cancer types investigate its potential role colon rectal adenocarcinoma (COADREAD).
Language: Английский
Research, Journal Year: 2025, Volume and Issue: 8
Published: Jan. 1, 2025
The intricate relationship between cancer, circadian rhythms, and aging is increasingly recognized as a critical factor in understanding the mechanisms underlying tumorigenesis cancer progression. Aging well-established primary risk for while disruptions rhythms are intricately associated with progression of various tumors. Moreover, itself disrupts leading to physiological changes that may accelerate development. Despite these connections, specific interplay processes their collective impact on remains inadequately explored literature. In this review, we systematically explore influence We discuss how core genes tumor prognosis, highlighting shared hallmarks such genomic instability, cellular senescence, chronic inflammation. Furthermore, examine aging, focusing crosstalk contributes tumorigenesis, proliferation, apoptosis, well metabolism stability. By elucidating common pathways linking review provides new insights into pathophysiology identifies potential therapeutic strategies. propose targeting regulation could pave way novel treatments, including chronotherapy antiaging interventions, which offer important benefits clinical management cancer.
Language: Английский
Citations
2
Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)
Published: Aug. 19, 2024
Drug resistance remains a significant challenge in cancer treatment. Recently, the interactions among various cell types within tumor microenvironment (TME) have deepened our understanding of mechanisms behind treatment resistance. Therefore, this review aims to synthesize current research focusing on infiltrating cells and drug suggesting that targeting TME could be viable strategy combat issue. Numerous factors, including inflammation, metabolism, senescence, hypoxia, angiogenesis, contribute Overexpression STAT3 is commonly associated with drug-resistant or stromal cells. Current often generalizes impact resistance, lacking specificity statistical robustness. Thus, future should take notice issue aim provide high-quality evidence. Despite existing limitations, overcome therapy hold promising valuable potential.
Language: Английский
Citations
9
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: July 30, 2024
Breast cancer (BC) is one of the most common and fatal malignancies among women worldwide. Circadian rhythms have emerged in recent studies as being involved pathogenesis breast cancer. In this paper, we reviewed molecular mechanisms by which dysregulation circadian genes impacts development BC, focusing on critical clock genes, brain muscle ARNT-like protein 1 (BMAL1) locomotor output cycles kaput (CLOCK). We discussed how rhythm disruption (CRD) changes tumor microenvironment (TME), immune responses, inflammation, angiogenesis. The CRD compromises surveillance features activities effectors, including CD8+ T cells tumor-associated macrophages, that are important an effective anti-tumor response. Meanwhile, review, discuss bidirectional interactions: age rhythms, aging further increases risk through reduced vasoactive intestinal polypeptide (VIP), affecting suprachiasmatic nucleus (SCN) synchronization, ability to repair damaged DNA, weakened immunity. These complex interplays open new avenues toward targeted therapies combination drugs with chronotherapy potentiate response while reducing progression for better outcomes. This review tries cover broad area emerging knowledge tumor-immune nexus affected
Language: Английский
Citations
6
Cancer Letters, Journal Year: 2024, Volume and Issue: 610, P. 217359 - 217359
Published: Nov. 27, 2024
Language: Английский
Citations
5
Critical Reviews in Oncology/Hematology, Journal Year: 2025, Volume and Issue: unknown, P. 104705 - 104705
Published: March 1, 2025
Language: Английский
Citations
0
International Journal of Cancer, Journal Year: 2025, Volume and Issue: unknown
Published: April 23, 2025
Abstract Single‐cell analysis is a transformative approach to understanding cellular heterogeneity in aging and cancer, interconnected processes driven by mechanisms like senescence immune modulation. This review explores how influences cancer initiation, progression, treatment resistance within the tumor microenvironment (TME). By examining recent studies using single‐cell technologies, we reveal nuanced roles of tumorigenesis, interactions, therapeutic outcomes. Aging closely tied with senescent cells demonstrating heightened proliferative, invasive, metastatic capabilities. Emerging senolytic therapies targeting aging‐related pathways hold promise for enhancing efficacy. Advanced tools such as spatial transcriptomics, molecular probes, artificial intelligence further refine our TME. integrating these future research can clarify intricate interactions between advancing precision oncology improving outcomes patients.
Language: Английский
Citations
0
Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)
Published: Sept. 11, 2024
Language: Английский
Citations
1
Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)
Published: Oct. 9, 2024
Recent studies have established a correlation between ADAMTSL2 (ADAMTS-like 2) and the development of various cancers. This study aims to conduct comprehensive pan-cancer analysis in 37 cancer types investigate its potential role colon rectal adenocarcinoma (COADREAD).
Language: Английский
Citations
1