Bifidobacterium adolescentis-derived nicotinic acid improves host skeletal muscle mitochondrial function to ameliorate sarcopenia
Cell Reports,
Journal Year:
2025,
Volume and Issue:
44(2), P. 115265 - 115265
Published: Feb. 1, 2025
Sarcopenia
significantly
diminishes
quality
of
life
and
increases
mortality
risk
in
older
adults.
While
the
connection
between
gut
microbiome
muscle
health
is
recognized,
underlying
mechanisms
are
poorly
understood.
In
this
study,
shotgun
metagenomics
revealed
that
Bifidobacterium
adolescentis
notably
depleted
individuals
with
sarcopenia,
correlating
reduced
mass
function.
This
finding
was
validated
aged
mice.
Metabolomics
analysis
identified
nicotinic
acid
as
a
key
metabolite
produced
by
B.
adolescentis,
linked
to
improvements
functionality
sarcopenia.
Mechanistically,
restores
nicotinamide
adenine
dinucleotide
(NAD+)
levels
muscle,
inhibits
FoxO3/Atrogin-1/Murf-1
axis,
promotes
satellite
cell
proliferation,
reducing
atrophy.
Additionally,
NAD+
activation
enhances
silent-information-regulator
1
(SIRT1)/peroxisome-proliferator-activated-receptor-γ-coactivator
1-alpha
(PGC-1α)
stimulating
mitochondrial
biogenesis
promoting
oxidative
metabolism
slow-twitch
fibers,
ultimately
improving
Our
findings
suggest
adolescentis-derived
could
be
promising
therapeutic
strategy
for
Language: Английский
Molecular Mechanisms and Potential Interventions During Aging-associated Sarcopenia
Xiaoqin Luo,
No information about this author
Jin Wang,
No information about this author
Qingqing Ju
No information about this author
et al.
Mechanisms of Ageing and Development,
Journal Year:
2024,
Volume and Issue:
unknown, P. 112020 - 112020
Published: Dec. 1, 2024
Language: Английский
UNLOCKING DIAGNOSIS OF SARCOPENIA: THE ROLE OF CIRCULATING BIOMARKERS - A CLINICAL SYSTEMATIC REVIEW
Mechanisms of Ageing and Development,
Journal Year:
2024,
Volume and Issue:
222, P. 112005 - 112005
Published: Nov. 8, 2024
Language: Английский
Non-Evidence-Based Dietary Restrictions in Hospital Nutrition and Their Impact on Malnutrition: A Narrative Review of International and National Guidelines
Sara Carnevale,
No information about this author
Assunta Vitale,
No information about this author
Monica Razzi
No information about this author
et al.
Dietetics,
Journal Year:
2024,
Volume and Issue:
3(4), P. 568 - 587
Published: Dec. 6, 2024
Background:
Malnutrition
is
a
major
issue
in
hospitals,
impacting
over
25%
of
patients.
It
can
arise
from
range
factors,
such
as
chronic
underfeeding,
diseases,
aging,
and
inappropriate
nutritional
care.
Unnecessary
fasting
the
use
incorrect
dietary
prescriptions
also
contribute
to
malnutrition,
regardless
patient’s
underlying
health
conditions.
Methods:
A
search
strategy
was
applied
identify
pertinent
articles
on
prescription
management
therapeutic
diets
hospital
settings
last
10
years
(2014–2024)
using
PubMed
database.
The
following
English
terms
their
combinations
were
used:
diet,
non-evidence-based
restriction,
food
service,
diets.
Only
national
or
international
guidelines
published
considered.
Results:
narrative
review
developed
through
analysis
two
settings.
main
that
should
have
limited
are
low-calorie,
low-carbohydrate,
low-protein,
low-sodium
because
they
inevitably
lead
reduction
caloric
and/or
protein
content,
limit
menu
choices,
make
recipes
less
palatable.
preventive
total
elimination
lactose
without
diagnostic
confirmation
be
avoided
for
intolerance
symptoms
diagnosis.
Fasting
after
surgery
avoided.
differ
part
terminology
bromatological
composition
diet.
Conclusions:
heterogeneity
terminologies
leads
further
confusion
determining
correct
procedure
managing
prescribing
Deepening
increasing
research
field
necessary
overcome
problem
provided
service
very
effective
medicine
providing
calories,
macronutrients,
micronutrients.
Language: Английский