Global, regional, and national burden of kidney cancer and attributable risk factors in adults aged 65 years and older from 1990 to 2021 and projections to 2040

BMC Cancer, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 15, 2025

Identifying the past and future burden of kidney cancer (KC) its temporal trends among older adults (≥ 65 years) at global, regional, national levels is critical for effective prevention strategies. The age-standardized incidence, prevalence, mortality, disability-adjusted life years (DALYs) were calculated using data from Global Burden Disease (GBD) study 1990 to 2021. These indicators stratified by sex, age, socio-demographic index (SDI). correlation between these SDI was assessed. Temporal quantified annual average percentage change (AAPC), 2022 2040 predicted Bayesian age-period-cohort (BAPC) model. global incidence rate (ASIR) KC increased 21.73 per 100,000 people in 26.74 2021, with an AAPC 0.67%. Age-standardized DALYs (ASDR) remained stable, while significant increases observed prevalence (AAPC = 1.24%, 95%CI: 1.14–1.34%) mortality 0.13%, 0.05–0.22%). From males consistently exhibited a higher disease than females, additionally, ASIR significantly all age subgroups. Regions also showed greater burden, Oceania had lowest almost countries territories. Czechia highest (92.25 people) ASDR (819.88 people). Smoking high body mass (BMI) risk factors population, their effects greatest region. Furthermore, expected continue decline through 2040. notable regional variations. However, it projected management smoking BMI remain major challenges KC, necessitating targeted clinical guidelines, particularly focusing on adults.

Language: Английский

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Global trends and projections of occupational trichloroethylene (TCE) exposure-associated kidney cancer: Insights of the Global Burden of Disease (GBD) Study 2021 from 1990 to 2021 and prediction to 2050

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 287, P. 117252 - 117252

Published: Nov. 1, 2024

Exposure to trichloroethylene (TCE) in occupations is associated with an increased risk of kidney cancer (KC). However, there a lack comprehensive study on the global burden occupational exposure TCE-related KC.

Language: Английский

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From Bench to Bedside: Translating Cellular Rejuvenation Therapies into Clinical Applications

Cells, Journal Year: 2024, Volume and Issue: 13(24), P. 2052 - 2052

Published: Dec. 12, 2024

Cellular rejuvenation therapies represent a transformative frontier in addressing age-related decline and extending human health span. By targeting fundamental hallmarks of aging—such as genomic instability, epigenetic alterations, mitochondrial dysfunction, cellular senescence—these aim to restore youthful functionality cells tissues, offering new hope for treating degenerative diseases. Recent advancements have showcased range strategies, including reprogramming, senolytic interventions, restoration, stem cell-based approaches, gene-editing technologies like CRISPR. Each modality has demonstrated substantial potential preclinical models is now being cautiously explored early-stage clinical trials. However, translating these from the laboratory practice presents unique challenges: safety concerns, delivery precision, complex regulatory requirements, ethical considerations, high costs impede widespread adoption. This review examines current landscape rejuvenation, highlighting key advancements, risks, strategies needed overcome hurdles.

Language: Английский

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The Hippo Signaling Pathway Manipulates Cellular Senescence

Cells, Journal Year: 2024, Volume and Issue: 14(1), P. 13 - 13

Published: Dec. 26, 2024

The Hippo pathway, a kinase cascade, coordinates with many intracellular signals and mediates the regulation of activities various downstream transcription factors their coactivators to maintain homeostasis. Therefore, aberrant activation pathway its associated molecules imposes significant stress on tissues cells, leading cancer, immune disorders, number diseases. Cellular senescence, mechanism by which cells counteract stress, prevents from unnecessary damage leads sustained cell cycle arrest. It acts as powerful defense against normal organ development aging-related On other hand, accumulation senescent without proper removal contributes or worsening cancer age-related A correlation was recently reported between cellular preserves tissue This review is first describe close relationship aging provides insights into mechanisms In addition, it describes advanced findings that may lead regeneration therapies drugs targeting rejuvenation.

Language: Английский

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