Homeostasis control in health and disease by the unfolded protein response

Nature Reviews Molecular Cell Biology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 5, 2024

Language: Английский

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The Golgi Apparatus: A Key Player in Innate Immunity

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 4120 - 4120

Published: April 8, 2024

The Golgi apparatus, long recognized for its roles in protein processing and vesicular trafficking, has recently been identified as a crucial contributor to innate immune signaling pathways. This review discusses our expanding understanding of the apparatus's involvement initiating activating these It highlights significance membrane connections between other organelles, such endoplasmic reticulum, mitochondria, endosomes, autophagosomes. These are vital efficient transmission signals activation effector responses. Furthermore, article delves into key pathways, including inflammasome-mediated caspase-1, cGAS-STING pathway, TLR/RLR signaling. Overall, this aims provide insights multifunctional nature apparatus impact on immunity.

Language: Английский

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Perinuclear organelle trauma at the nexus of cardiomyopathy pathogenesis arising from loss of function LMNA mutation

Nucleus, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 9, 2025

Over the past 25 years, nuclear envelope (NE) perturbations have been reported in various experimental models with mutations LMNA gene. Although hypothesis that NE from are a fundamental feature of striated muscle damage has garnered wide acceptance, molecular sequalae provoked by and how they underlie disease pathogenesis such as cardiomyopathy (LMNA cardiomyopathy) remain poorly understood. We recently shed light on one consequence, employing cardiomyocyte-specific Lmna deletion vivo adult heart. observed extensive prior to cardiac function deterioration collateral perinuclear space. The Golgi is particularly affected, leading cytoprotective stress responses likely disrupted progressive itself. In this review, we discuss etiology 'organelle trauma' nexus between pathogenesis.

Language: Английский

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Regulation of virion production by the ORF8 signal peptide across SARS-CoV-2 variants

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: March 6, 2024

The open reading frame 8 (ORF8), an accessory protein of SARS-CoV-2, is prone to deletions and mutations across different viral variants, which was first described in several Singapore variants. reason why evolution favors loss or inactivation ORF8 not fully understood, although the effects on inflammation, immune evasion, disease severity have been described. Here we show using clinical deficient isolates, virus like particles (VLPs) replicons that expression dampens particle production. physically interacts with Spike induces Golgi fragmentation, overall contributing less Using systematic deletions, mapped reducing function its N terminal signal peptide. Interestingly, this part severely truncated recent XBB.1.5 variant, when restored, suppresses production context entire genome. Collectively, our data support model evolutionary pressure exists delete sequence SARS-CoV-2 variants enable

Language: Английский

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A Novel Monoallelic ALG5 Variant Causing Late-Onset ADPKD and Tubulointerstitial Fibrosis

Kidney International Reports, Journal Year: 2024, Volume and Issue: 9(7), P. 2209 - 2226

Published: April 15, 2024

Monoallelic variants in the

Language: Английский

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GOLPH3 promotes calcium oxalate-induced renal injury and fibrosis through Golgi stress-mediated apoptosis and inflammatory responses

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 4, 2025

Language: Английский

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Exploring Stressors: Impact on Cellular Organelles and Implications for Cellular Functions

Stresses, Journal Year: 2025, Volume and Issue: 5(2), P. 26 - 26

Published: April 4, 2025

Cellular stressors have been demonstrated to exert a substantial influence on the functionality of organelles, thereby impacting cellular homeostasis and contributing development disease pathogenesis. This review aims examine impact diverse stressors, including environmental, chemical, biological, physical factors, critical organelles such as cell membrane, mitochondria, endoplasmic reticulum, Golgi apparatus, lysosomes, membrane-less organelles. The intricate molecular mechanisms underlying stress responses, encompassing oxidative stress, protein misfolding, metabolic reprogramming, capacity elicit adaptive responses or culminate in pathological conditions. interplay between these organelle dysfunction has implicated myriad diseases, neurodegenerative disorders, cancer, immune-related pathologies. A comprehensive understanding by which respond can offer valuable insights into therapeutic strategies aimed at mitigating damage.

Language: Английский

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Autophagy regulation and redox perturbation by transcrocetin suppress the growth of endometriosis

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 173, P. 116284 - 116284

Published: Feb. 23, 2024

Until non-hormonal therapeutic targets for endometriosis are suggested, we focused on mitochondrial function and autophagy regulation in the disease. Transcrocetin is a carotenoid retinoic acid with high antioxidant potency antiproliferative effects several diseases. In this study, demonstrated mechanisms of transcrocetin using End1/E6E7 VK2/E6E7 cell lines. suppressed viability proliferation these lines did not affect normal uterine stromal cells. p21 Waf1/Cip1 as cycle regulator target p53, were increased by caused G1 arrest via inhibition cyclin-dependent kinase activity, which might further cause death. Furthermore, confirmed endoplasmic reticulum stress calcium ion dysregulation cytosol matrix, disrupting membrane potential. Mitochondrial bioenergetics transcrocetin, oxidative phosphorylation-related gene expression was downregulated. Moreover, cells regulated transcrocetin-induced stress. Finally, verified impairment autophagic flux following pre-treatment chloroquine. Therefore, may be potent alternative endometriosis.

Language: Английский

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Emerging Evidence of Golgi Stress Signaling for Neuropathies

Neurology International, Journal Year: 2024, Volume and Issue: 16(2), P. 334 - 348

Published: March 7, 2024

The Golgi apparatus is an intracellular organelle that modifies cargo, which transported extracellularly through the nucleus, endoplasmic reticulum, and plasma membrane in order. First, general function of reviewed and, then, stress signaling discussed. In addition to six main pathways, two pathways have been increasingly reported recent years are described this review. focus then shifts neurological disorders, examining major such as Alzheimer’s disease, Parkinson’s Huntington’s disease. review also encompasses findings related other diseases, including hypomyelinating leukodystrophy, frontotemporal spectrum disorder/amyotrophic lateral sclerosis, microcephaly, Wilson’s prion Most these disorders cause fragmentation stress. As a result, strong signals may act induce apoptosis.

Language: Английский

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Discovery of Hepatitis B Virus Subviral Particle Biogenesis Inhibitors from a Bioactive Compound Library

Antiviral Research, Journal Year: 2024, Volume and Issue: 228, P. 105955 - 105955

Published: July 2, 2024

Language: Английский

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