Post COVID-19 and Long COVID Symptoms in Otorhinolaryngology—A Narrative Review
Journal of Clinical Medicine,
Journal Year:
2025,
Volume and Issue:
14(2), P. 506 - 506
Published: Jan. 14, 2025
Post/Long
COVID
(syndrome)
is
defined
as
a
condition
with
symptoms
persisting
for
more
than
12
weeks
after
the
onset
of
SARS-CoV-2
infection
that
cannot
be
explained
otherwise.
The
prevalence
self-reported
otorhinolaryngological
high.
aim
this
review
was
to
analyze
current
literature
regarding
actual
prevalence,
knowledge
etiopathology,
and
evidence-based
treatment
recommendations
otorhinolaryngology-related
symptoms.
A
systematic
search
articles
published
since
2019
in
PubMed
ScienceDirect
performed
resulted
108
articles.
These
were
basis
formed
comprehensive
series
consented
therapy
statements
on
most
important
Otorhinolaryngological
did
not
appear
isolated
but
part
multi-organ
syndrome.
Self-reported
often
confirmed
by
objective
testing.
estimated
anosmia,
dysgeusia,
cough,
facial
palsy,
hoarseness/dysphonia,
acute
hearing
loss,
tinnitus,
vertigo/dizziness
about
4%,
2%,
4-19%,
0%,
17-20%,
8%,
20%,
5-26%,
respectively.
There
are
manifold
theoretical
concepts
etiopathology
different
symptoms,
there
no
clear
proof.
This
certainly
contributes
fact
effective
specific
option
any
mentioned.
Healthcare
pathways
must
established
so
can
recognized
evaluated
otorhinolaryngologists
provide
counseling.
would
also
help
establish
selectively
include
patients
clinical
trials
investigating
therapeutic
concepts.
Language: Английский
Spatial transcriptomics of the epipharynx in long COVID identifies SARS-CoV-2 signalling pathways and the therapeutic potential of epipharyngeal abrasive therapy
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: March 12, 2025
Abstract
In
this
study,
the
critical
role
of
epipharynx
in
managing
long-term
coronavirus
disease
2019
(COVID-19),
and
particular,
how
residual
SARS-CoV-2
RNA
affects
signalling
pathways
were
investigated
via
spatial
gene
expression
analysis
(Visium
HD).
Moreover,
we
hypothesize
that
epipharyngeal
abrasive
therapy
(EAT)
targeting
could
improve
long
COVID
symptoms
by
modulating
local
inflammation
expression.
We
conducted
a
comparative
profiles
three
patients
with
two
control
individuals
without
COVID-19.
Residual
was
detected
COVID,
along
activation
epithelial
immune
cells.
After
EAT,
viral
either
completely
cleared
or
significantly
reduced.
T-cell
receptor
suppressed;
levels
proinflammatory
cytokines,
such
as
interleukin-6
tumour
necrosis
factor-α,
reduced;
excessive
antibody
production
mitigated.
Histology
showed
EAT
effectively
eliminated
inflamed,
dysfunctional
ciliated
epithelium.
This
study
clarifies
has
effects
on
response
epipharynx,
emphasizing
need
to
focus
chronic
epipharyngitis
potential
cause
COVID.
Furthermore,
may
offer
promising
approach
alleviating
persistent
symptoms.
Language: Английский