Oral Oncology, Journal Year: 2023, Volume and Issue: 149, P. 106665 - 106665
Published: Dec. 22, 2023
Language: Английский
Oncology Reviews, Journal Year: 2025, Volume and Issue: 18
Published: Jan. 20, 2025
Worldwide, head and neck cancers (HNCs) account for approximately 900,000 cases 500,000 deaths annually, with their incidence continuing to rise. Carcinogenesis is a complex, multidimensional molecular process leading cancer development, in recent years, the role of nerves pathogenesis various malignancies has been increasingly recognized. Thanks abundant innervation region, peripheral nervous system gained considerable interest its possible development progression HNCs. Intratumoral parasympathetic, sympathetic, sensory nerve fibers are emerging as key players potential targets novel anti-cancer pain-relieving medications different tumors, including This review explores nerve-cancer interactions, perineural invasion (PNI), cancer-related axonogenesis, neurogenesis, reprogramming, an emphasis on mechanisms, mediators clinical implications. PNI, adverse histopathologic feature, widely investigated However, prognostic value remains debated due inconsistent results when classified dichotomously (present/absent). Emerging evidence suggests that quantitative qualitative descriptions PNI may better reflect usefulness. The also examines therapies targeting crosstalk highlights influence HPV status tumor innervation. By synthesizing current knowledge, challenges, future perspectives, this offers insights into basis involvement HNCs therapeutic approaches.
Language: Английский
Citations
1
Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)
Published: Jan. 31, 2025
Oral cancer ranks among the most common malignancies within head and neck region; however, its etiology remains inadequately understood despite substantial research advances in recent years. Many studies highlight regulatory role of circular RNAs (circRNAs) human cancers, suggesting their potential as biomarkers. However, specific mechanisms oral are not well understood. This study analyzed circRNAs expression cancer, identifying circRNF13 (circbaseID: has_circ_0006801) having elevated cells tissues. Our demonstrated that is correlated with increased tumor grade stage cancer. Results from both vitro vivo experiments indicated enhances cell proliferation growth, while concurrently diminishing sensitivity to cisplatin. Mechanistically, interacts m6A "reader" protein IGF2BP1, inhibiting ubiquitin-mediated degradation promoting phase separation formation. Subsequently, augments stability ITGB1 mRNA via IGF2BP1 a manner dependent on modification. The modification modulated by thereby malignant progression cells. evidence positions crucial molecule pathogenesis suggests therapeutic target. discovery enriches our understanding mechanistic circRNAs.
Language: Английский
Citations
1
Cancers, Journal Year: 2025, Volume and Issue: 17(2), P. 302 - 302
Published: Jan. 17, 2025
Background: The aim of this study was to evaluate biomarkers and biological characteristics tumor biopsies from patients with head neck cancer (HNC) assess the risk early death. Furthermore, we analyzed whether any combination markers could be used for prognostication death within six months after diagnosis. Materials Methods: Patients diagnosed HNC, receiving curative treatment decision at a multidisciplinary board meeting, who died diagnosis were included in study. Nine identified matched according site stage seventeen survived least two years. Results: expression compared between early-death survivors. There significantly higher Ki-67 than those surviving years, mean difference 21% (p = 0.038). A significant cytoplasmic survivin noted where had increased survivors 0.021). intensity staining differed groups 0.006). Conclusions: results pilot indicate that Ki67 potential prognostic HNC possibly panel value making.
Language: Английский
Citations
0
Journal of Pharmacy And Bioallied Sciences, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 25, 2025
A BSTRACT Introduction: Oral squamous cell carcinoma (OSCC) is a prevalent malignancy, with histopathological features playing crucial role in predicting clinical outcomes. Tumor budding, lymphovascular invasion, and depth of invasion are key indicators used to assess prognosis therapeutic response. The objective this research examine the correlation between these parameters patient Methods: This retrospective analysis included patients diagnosed OSCC. examined were tumor invasion. Clinical outcomes, including recurrence survival rates, analyzed. Results: budding significantly associated increased rates poorer Lymphovascular also showed strong advanced disease stages. Conclusion: features, particularly significant predictors outcomes OSCC patients. These should be emphasized treatment planning
Language: Английский
Citations
0
Immuno, Journal Year: 2025, Volume and Issue: 5(1), P. 8 - 8
Published: Feb. 25, 2025
NK cells have traditionally been classified as effectors of innate immunity, even though they also exhibit some features adaptive immunity such memory. contribute to the lysis and growth inhibition cancer, mediating direct cytotoxicity antibody-dependent cellular (ADCC) regulating functions other immune cells, respectively. regulate function via release inflammatory cytokines chemokines. Currently, cell therapeutics in oral cancer less efficient due several limitations, follows: (a) lower percentages peripheral blood cells; (b) limited survival decreased especially tumor microenvironment; (c) a lack tools or methodologies expand activate levels that are required for effective targeting cancer. To overcome these we established demonstrated novel technology activating expanding highly functional coined supercharged (sNK) cells. This review summarizes characteristics sNK highlights their superior anti-cancer activity when compared primary activated
Language: Английский
Citations
0
Oral Diseases, Journal Year: 2025, Volume and Issue: unknown
Published: March 3, 2025
ABSTRACT Background This article aims to provide a broad overview of the oral squamous cell carcinoma (OSCC) tumor stroma, describing and discussing recent advances in understanding different stromal elements their roles progression. We also describe potential new therapeutic approaches targeting stroma. Methods A literature review on role biomarkers OSCC was conducted. narrative current undertaken synthesize contexts with elaboration summary. Results The crosstalk between cancer cells major driver progression metastasis, has increasingly been unveiled. highlights tumor‐to‐stroma ratio (TSR) as valuable prognostic marker OSCC, high content (TSR > 50%) linked poorer survival. On other hand, tumor‐infiltrating lymphocytes are associated improved prognosis longer Furthermore, emerging markers, such cancer‐associated fibroblasts desmoplastic reactions, play significant promoting invasiveness resistance therapy. identifies gaps evidence proposes directions for future research further clarify utility components. Conclusions Stromal markers insights into could enhance clinical decision‐making, emphasizing complexity
Language: Английский
Citations
0
Oral Diseases, Journal Year: 2025, Volume and Issue: unknown
Published: March 24, 2025
ABSTRACT Background Tumor‐stroma ratio (TSR) has been recognized as a significant prognostic factor in various cancers. This systematic review evaluates the role of TSR head and neck squamous cell carcinoma (HNSCC) its association with patient outcomes such overall survival (OS), disease‐free (DFS), disease‐specific (DSS), lymph node metastasis (LNM). Methods A comprehensive search was conducted across Scopus, Embase, PubMed, Web Science. Nineteen studies were included. Data extraction quality assessment performed progressively, meta‐analyses. All assessed using hematoxylin eosin staining tissue samples. The meta‐analyses focused on impact OS, DFS, DSS, LNM, providing pooled hazard ratios (HRs) odds (ORs) corresponding confidence intervals (CIs). Results Meta‐analysis revealed between OS (HR 1.99, 95% CI 1.71–2.32, p < 0.001), DFS 2.07, 1.80–2.39, DSS 2.33, 1.95–2.78, LNM (OR 1.76, 1.15–2.70, = 0.01). Minimal to low heterogeneity detected among studies, no publication bias observed. Conclusions can effectively identify high‐risk patients, being reliable marker that could be readily integrated into routine pathology practice for HNSCC.
Language: Английский
Citations
0
BMC Cancer, Journal Year: 2025, Volume and Issue: 25(1)
Published: April 22, 2025
Oral cavity squamous cell carcinoma (OCSCC) is a common malignancy with high morbidity and mortality. This research seeks to assess the correlation between Naples Prognostic Score (NPS) survival outcomes in patients OCSCC who are receiving surgical treatment, highlighting its potential as prognostic tool for predicting patient outcomes. retrospective study included 589 from two large regional medical centers central China, treated February 2008 September 2019. Inclusion criteria mandated confirmed diagnosis, age ≥ 18 years, radical surgery, while distant metastasis, multiple tumors, or insufficient data were excluded. Data on 29 clinicopathological variables, including demographic details, tumor characteristics, nutritional/inflammatory markers, collected. The statistical approach both univariate multivariate Cox regression models determine factors associated disease-free (DFS) overall (OS). Additionally, Kaplan-Meier analysis was employed evaluate effect of adjuvant radiotherapy various NPS subgroups. Surgical margin status, ENE, NPS, age-adjusted Charlson comorbidity index (ACCI), American Joint Committee Cancer (AJCC) stage identified independent DFS. Similarly, Eastern Cooperative Oncology Group Performance Status (ECOG PS), extranodal extension (ENE), ACCI, AJCC found be OS. A higher poorer prognosis. In III-IVb 1-2, significantly improved DFS Likewise, 3-4, better OS However, no significant impact observed I-II those 0, regardless stage. underscores importance stratifying therapy. beneficial indicator patients. Its integration into clinical practice may assist risk stratification treatment decision-making, particularly undergoing radiotherapy.
Language: Английский
Citations
0
Current Cancer Drug Targets, Journal Year: 2024, Volume and Issue: 24(10), P. 1047 - 1060
Published: Feb. 1, 2024
Oral squamous cell carcinoma (OSCC) is one of the most prevalent cancers with poor prognosis in head and neck. Elucidating molecular mechanisms underlying OSCC occurrence development important for therapy. Dysregulated palmitoylation-related enzymes have been reported several but OSCC.
Language: Английский
Citations
3
Journal of Personalized Medicine, Journal Year: 2023, Volume and Issue: 13(11), P. 1618 - 1618
Published: Nov. 17, 2023
Advances in the development of pharmacological treatment oral cancer require tumor models capable simulating complex biology microenvironment. The spread three-dimensional has changed scenery vitro cell culture techniques, contributing to translational oncology. Still, full extent their application preclinical drug trials is yet be understood. Therefore, present scoping review protocol was established screen literature on using drug-testing assays context cancer. This will conducted based guidelines by Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension Scoping Review (PRISMA-ScR). We search PubMed/Medline, Web Science, Scopus, Embase databases, as well gray literature, including peer-reviewed research articles involving 3D applied drug-assessment published from 1 March 2013 until 2023. Data charted, findings described according predetermined questions interest. these a narrative manner.
Language: Английский
Citations
4