Multi-omics pan-cancer study of SPTBN2 and its value as a potential therapeutic target in pancreatic cancer DOI Creative Commons

Hongliang Chang,

Hong Chen, Taiheng Ma

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: April 29, 2024

Abstract SPTBN2 is a protein-coding gene that closely related to the development of malignant tumors. However, its prognostic value and biological function in pan-cancer, especially pancreatic cancer (PAAD), have not been reported. In present study, novel exploration potential mechanism PAAD was conducted using multi-omics background pan-cancer. Via various database analysis, up-regulated expression detected most tumor tissues examined. Overexpression kidney renal clear cell patients potentially affected overall survival, disease-specific progression-free interval. PAAD, can be used as an independent factor affecting prognosis. Mutations amplification were detected, with abnormal methylation survival outcome patients. Immunoassay results demonstrate biomarker for predicting therapeutic response may influence immunotherapy efficacy by regulating levels CD8 + T cells neutrophil infiltration. Results from enrichment analysis indicated regulate via immune pathways. Thus, target based on crucial role PAAD.

Language: Английский

Multi-omics pan-cancer study of SPTBN2 and its value as a potential therapeutic target in pancreatic cancer DOI Creative Commons

Hongliang Chang,

Hong Chen, Taiheng Ma

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: April 29, 2024

Abstract SPTBN2 is a protein-coding gene that closely related to the development of malignant tumors. However, its prognostic value and biological function in pan-cancer, especially pancreatic cancer (PAAD), have not been reported. In present study, novel exploration potential mechanism PAAD was conducted using multi-omics background pan-cancer. Via various database analysis, up-regulated expression detected most tumor tissues examined. Overexpression kidney renal clear cell patients potentially affected overall survival, disease-specific progression-free interval. PAAD, can be used as an independent factor affecting prognosis. Mutations amplification were detected, with abnormal methylation survival outcome patients. Immunoassay results demonstrate biomarker for predicting therapeutic response may influence immunotherapy efficacy by regulating levels CD8 + T cells neutrophil infiltration. Results from enrichment analysis indicated regulate via immune pathways. Thus, target based on crucial role PAAD.

Language: Английский

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