Lithium Promotes Osteogenesis via Rab11a-Facilitated Exosomal Wnt10a Secretion and β-Catenin Signaling Activation

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(24), P. 30793 - 30809

Published: June 4, 2024

Both bone mesenchymal stem cells (BMSCs) and their exosomes suggest promising therapeutic tools for regeneration. Lithium has been reported to regulate BMSC function engineer improve regeneration in patients with glucocorticoid-induced osteonecrosis of the femoral head. However, mechanisms by which lithium promotes osteogenesis have not elucidated. Here, we demonstrated that BMSCs via lithium-induced increases secretion exosomal Wnt10a activate Wnt/β-catenin signaling, whose is correlated enhanced MARK2 activation increase trafficking Rab11a Rab11FIP1 complexes together plasma membrane. Then, compared proosteogenic effects derived from lithium-treated or untreated (Li-Exo Con-Exo) both vitro vivo. We found that, Con-Exo, Li-Exo had superior abilities promote uptake osteogenic differentiation BMSCs. To optimize vivo application these hydrogels, fabricated Li-Exo-functionalized gelatin methacrylate (GelMA) are more effective at promoting repair than Con-Exo. Collectively, findings demonstrate mechanism great promise engineering regeneration, warranting further exploration clinical practice.

Language: Английский

Inflammatory Myofibroblastic Tumor of the Sciatic Nerve Mimicking Lumbar Disc Herniation: A Diagnostic Challenge

World Journal of Oncology, Journal Year: 2024, Volume and Issue: 15(3), P. 521 - 525

Published: May 7, 2024

Inflammatory myofibroblastic tumors (IMTs), which involve the proliferation of fibroblastic-myofibroblastic cells mixed with inflammatory infiltrates, are exceedingly rare in extremities. There no reported IMTs involving sciatic nerve. This type involvement may cause entrapment nerve, whose symptoms mimic lumbar disc herniation (LDH), especially when it occurs patients degenerative disease. We describe case a 40-year-old male disease accompanied by IMT nerve mimicked LDH and posed diagnostic challenge. showed course as well systematic imaging manifestations discussed their therapeutic management.

Language: Английский

Proximal Femoral Metastasis From Epidermal Growth Factor Receptor-Mutated Lung Adenocarcinoma Mimicking Osteosarcoma on Magnetic Resonance Imaging

World Journal of Oncology, Journal Year: 2024, Volume and Issue: 15(4), P. 731 - 735

Published: July 6, 2024

The aggressive nature of lung cancer is frequently accompanied by a high incidence bone metastasis; however, proximal femoral metastasis from comparatively uncommon when compared to other malignancies. In this report, we present the case 53-year-old Asian male who presented with pain in left thigh and back. Magnetic resonance imaging revealed severe destruction involvement adjacent soft tissue mass at thigh, exhibiting findings that mimic osteosarcoma. Subsequent biopsy confirmed diagnosis epidermal growth factor receptor (

Language: Английский